Abstract：
:α-Synuclein has recently been implicated in the pathophysiology of alcohol abuse due to its role in dopaminergic neurotransmission. In these studies, genetic variability in the α-synuclein gene influences its expression which may contribute to susceptibility to chronic alcohol abuse. Real-time PCR was used to quantify α-synuclein mRNA expression in autopsy samples of human dorsolateral prefrontal cortex. Because of the association between length of the α-synuclein-repeat 1 microsatellite marker and expression levels of the gene, this marker was genotyped in a Caucasian sample of 126 controls and 117 alcoholics using capillary gel electrophoresis. The allele and genotype frequencies of α-synuclein-repeat 1 marker differed significantly between alcoholics and controls. Alcoholics had greater frequencies of the shortest allele found (267 bp). The shortest allele of the α-synuclein-repeat 1 marker was associated with decreased expression of α-synuclein in prefrontal cortex. Individuals with at least one copy of the 267 bp allele were more likely to exhibit an alcohol abuse phenotype. These results suggest that individuals with the 267 bp allele may be at increased risk of developing alcoholism and that genetic variation at the α-synuclein-repeat 1 locus may influence α-synuclein expression in the prefrontal cortex.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Janeczek P,MacKay RK,Lea RA,Dodd PR,Lewohl JMdoi
10.1111/j.1369-1600.2012.00495.xsubject
Has Abstractpub_date
2014-05-01 00:00:00pages
509-15issue
3eissn
1355-6215issn
1369-1600journal_volume
19pub_type
杂志文章abstract：:Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/1355621961000125046
更新日期：1996-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/135562101200100571
更新日期：2002-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12595
更新日期：2018-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2000.tb00190.x
更新日期：2000-07-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12765
更新日期：2020-05-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2020-08-04 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12188
更新日期：2015-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1369-1600.2007.00082.x
更新日期：2008-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 评论,杂志文章
doi：10.1111/adb.12265
更新日期：2017-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12959
更新日期：2020-08-13 00:00:00
abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219971641
更新日期：1999-04-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219871994
更新日期：1998-10-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12419
更新日期：2017-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210020077046
更新日期：2001-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12876
更新日期：2021-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2012.00476.x
更新日期：2013-11-01 00:00:00
abstract：:Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210500223769
更新日期：2005-09-01 00:00:00
abstract：:Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12356
更新日期：2017-05-01 00:00:00
abstract：:We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12496
更新日期：2018-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12558
更新日期：2018-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章,评审
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更新日期：2017-07-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00393.x
更新日期：2013-05-01 00:00:00
abstract：:While the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. The focus of the present study is to determine whether genetic variation in the tryptophan hyd...
journal_title：Addiction biology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1369-1600.2006.00005.x
更新日期：2006-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219872074
更新日期：1998-07-01 00:00:00
abstract：:In keeping with its ability to control the mesoaccumbens dopamine (DA) pathway, the serotonin2C receptor (5-HT2C R) plays a key role in mediating the behavioral and neurochemical effects of drugs of abuse. Studies assessing the influence of 5-HT2C R agonists on cocaine-induced responses have suggested that 5-HT2C Rs c...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12137
更新日期：2015-05-01 00:00:00
abstract：:Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12189
更新日期：2016-01-01 00:00:00
abstract：:The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12247
更新日期：2016-05-01 00:00:00
abstract：:One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice. C57BL/6J mice were trained in operant conditioning maintain...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00423.x
更新日期：2012-07-01 00:00:00
abstract：:Poor working memory is linked to future risk-taking behaviors. Lifelong risk of habitual drug use is highest in individuals who initiate use in early adolescence. We sought to determine in rats whether juvenile traits, specifically poor working memory and low salivary brain-derived neurotrophic factor (BDNF), are rela...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12535
更新日期：2018-05-01 00:00:00
