Risk factors for alcoholic liver disease.

abstract：:Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investig...

journal_title：Addiction biology

authors： Martin-Rodriguez JF,Ruiz-Veguilla M,Alvarez de Toledo P,Aizpurua-Olaizola O,Zarandona I,Canal-Rivero M,Rodriguez-Baena A,Mir P

更新日期：2020-04-23 00:00:00

abstract：:Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psych...

journal_title：Addiction biology

authors： Kuhn J,Gründler TO,Bauer R,Huff W,Fischer AG,Lenartz D,Maarouf M,Bührle C,Klosterkötter J,Ullsperger M,Sturm V

更新日期：2011-10-01 00:00:00

abstract：:Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...

journal_title：Addiction biology

authors： Tabernero MJ,Bermejo AM,Fernandez P

更新日期：1999-10-01 00:00:00

abstract：:The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...

journal_title：Addiction biology

authors： Herman AI,Conner TS,Anton RF,Gelernter J,Kranzler HR,Covault J

更新日期：2011-01-01 00:00:00

abstract：:While the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. The focus of the present study is to determine whether genetic variation in the tryptophan hyd...

journal_title：Addiction biology

authors： Dahl JP,Cubells JF,Ray R,Weller AE,Lohoff FW,Ferraro TN,Oslin DW,Kampman KM,Dackis C,Tang Y,Gelernter J,Kranzler HR,O'Brien CP,Berrettini WH

更新日期：2006-03-01 00:00:00

abstract：:Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...

journal_title：Addiction biology

authors： Wu Y,Li Y,Yang X,Sui N

更新日期：2014-01-01 00:00:00

abstract：:In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of 'Pathological Gambling' ('PG'). Some academic opinion favors leaving PG in the 'Impulse Control Disorder' ('ICD') category, as in ICD-10, whereas others a...

journal_title：Addiction biology

authors： Fauth-Bühler M,Mann K,Potenza MN

更新日期：2017-07-01 00:00:00

abstract：:Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inabilit...

journal_title：Addiction biology

authors： Hagerty SL,YorkWilliams SL,Bidwell LC,Weiland BJ,Sabbineni A,Blaine SK,Bryan AD,Hutchison KE

更新日期：2020-01-01 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:Nicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers' brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers'. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors ma...

journal_title：Addiction biology

authors： Das D,Cherbuin N,Anstey KJ,Sachdev PS,Easteal S

更新日期：2012-07-01 00:00:00

abstract：:Substance use disorder is a complex disease created in part by maladaptive learning and memory mechanisms following repeated drug use. Exposure to drug-associated stimuli engages prefrontal cortex circuits, and dysfunction of the medial prefrontal cortex (mPFC) is thought to underlie drug-seeking behaviors. Growing ev...

journal_title：Addiction biology

authors： Jorgensen ET,Gonzalez AE,Harkness JH,Hegarty DM,Thakar A,Burchi DJ,Aadland JA,Aicher SA,Sorg BA,Brown TE

更新日期：2020-08-04 00:00:00

abstract：:The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...

journal_title：Addiction biology

authors： Adinoff B,Harris TS,Gu H,Stein EA

更新日期：2017-05-01 00:00:00

abstract：:Previous work suggests a role for dopamine D3-like receptors in psychostimulant reinforcement. The development of new compounds acting selectively at dopamine D3 receptors has opened new possibilities to explore the role of these receptors in animal models of psychostimulant dependence. Here we investigated whether th...

journal_title：Addiction biology

authors： Orio L,Wee S,Newman AH,Pulvirenti L,Koob GF

更新日期：2010-07-01 00:00:00

abstract：:Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...

journal_title：Addiction biology

authors： Roldán M,Echeverry-Alzate V,Bühler KM,Sánchez-Diez IJ,Calleja-Conde J,Olmos P,Boehm SL,Maldonado R,Rodríguez de Fonseca F,Santiago C,Gómez-Gallego F,Giné E,López-Moreno JA

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neur...

journal_title：Addiction biology

authors： Chu NN,Xia W,Yu P,Hu L,Zhang R,Cui CL

更新日期：2008-03-01 00:00:00

abstract：:We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 ...

journal_title：Addiction biology

authors： Reginsson GW,Ingason A,Euesden J,Bjornsdottir G,Olafsson S,Sigurdsson E,Oskarsson H,Tyrfingsson T,Runarsdottir V,Hansdottir I,Steinberg S,Stefansson H,Gudbjartsson DF,Thorgeirsson TE,Stefansson K

更新日期：2018-01-01 00:00:00

abstract：:This study employs an oral operant conditioning paradigm to evaluate the effects of repeated social defeat during adolescence on the reinforcing and motivational actions of ethanol in adult OF1 mice. Social interaction, emotional and cognitive behavioral aspects were also analyzed, and real-time polymerase chain react...

journal_title：Addiction biology

authors： Rodriguez-Arias M,Navarrete F,Blanco-Gandia MC,Arenas MC,Bartoll-Andrés A,Aguilar MA,Rubio G,Miñarro J,Manzanares J

更新日期：2016-01-01 00:00:00

abstract：:Although substantial research effort has focused on developing pharmacological treatments for cocaine abuse, no effective medications have been developed. Recent studies show that enzymes that metabolize cocaine in the periphery, forestalling its entry into the brain, can prevent cocaine toxicity and its behavioral ef...

journal_title：Addiction biology

authors： Schindler CW,Justinova Z,Lafleur D,Woods D,Roschke V,Hallak H,Sklair-Tavron L,Redhi GH,Yasar S,Bergman J,Goldberg SR

更新日期：2013-01-01 00:00:00

abstract：:The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...

journal_title：Addiction biology

authors： Zhang JT,Yao YW,Li CS,Zang YF,Shen ZJ,Liu L,Wang LJ,Liu B,Fang XY

更新日期：2016-05-01 00:00:00

abstract：:Schizophrenia is a mental disorder characterized by a series of positive, negative or cognitive symptoms but with also the particularity of exhibiting a high rate of co-morbid use of drugs of abuse. While more than 80% of schizophrenics are smokers, the second most consumed drug is alcohol, with dramatic consequences ...

journal_title：Addiction biology

authors： Jeanblanc J,Balguerie K,Coune F,Legastelois R,Jeanblanc V,Naassila M

更新日期：2015-05-01 00:00:00

abstract：:The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim, male and female C57BL/6J mice (n = 60 per sex) were exposed to the drinking in the dark (DID) model for 4 weeks (DID-1 to DID-4). Dose-response effects of CBD on t...

journal_title：Addiction biology

authors： Viudez-Martínez A,García-Gutiérrez MS,Manzanares J

更新日期：2020-05-01 00:00:00

abstract：:Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...

journal_title：Addiction biology

authors： Solecki WB,Szklarczyk K,Pradel K,Kwiatkowska K,Dobrzański G,Przewłocki R

更新日期：2018-03-01 00:00:00

abstract：:It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subje...

journal_title：Addiction biology

authors： Loeber S,Vollstädt-Klein S,von der Goltz C,Flor H,Mann K,Kiefer F

更新日期：2009-04-01 00:00:00

abstract：:In our society every second polytraumatized patient is a chronic alcoholic. A patient's alcohol-related history is often unavailable and laboratory markers are not sensitive or specific enough to detect alcohol-dependent patients who are at risk of developing alcohol withdrawal syndrome (AWS) during their post-traumat...

journal_title：Addiction biology

authors： Spies CD,Rommelspacher H,Winkler T,Müller C,Brummer G,Funk T,Berger G,Fell M,Blum S,Specht M,Hannemann L,Schaffartzik W

更新日期：1996-01-01 00:00:00

abstract：:The technique of domiciliary rapid opiate detoxification (ROD) developed in Asturias since 1994 enables patients dependent on heroin and/or methadone (or other opiates) to start antagonist maintenance with a full dose of naltrexone (50 mg) and largely recover from the acute opiate withdrawal syndrome in a few hours at...

journal_title：Addiction biology

authors： Carreño JE,Bobes J,Brewer C,Alvarez CE,San Narciso GI,Bascarán MT,Sánchez del Río J

更新日期：2002-04-01 00:00:00

abstract：:Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...

journal_title：Addiction biology

authors： Lawn W,Mithchener L,Freeman TP,Benattayallah A,Bisby JA,Wall MB,Dodds CM,Curran HV,Morgan CJA

更新日期：2020-07-01 00:00:00

abstract：:The AA (alko, alcohol) and ANA (alko, non-alcohol) rat lines were among the earliest rodent lines produced by bidirectional selection for ethanol preference. The purpose of this review is to highlight the strategies for understanding the neurobiological factors underlying differential alcohol-drinking behavior in thes...

journal_title：Addiction biology

authors： Sommer W,Hyytiä P,Kiianmaa K

更新日期：2006-09-01 00:00:00

abstract：:It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic r...

journal_title：Addiction biology

authors： Owens MM,MacKillop J,Gray JC,Beach SRH,Stein MD,Niaura RS,Sweet LH

更新日期：2018-09-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...

journal_title：Addiction biology

authors： Navarrete F,Rubio G,Manzanares J

更新日期：2014-09-01 00:00:00

abstract：:Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and funct...

journal_title：Addiction biology

authors： Kaarre O,Kallioniemi E,Könönen M,Tolmunen T,Kekkonen V,Kivimäki P,Heikkinen N,Ferreri F,Laukkanen E,Määttä S

更新日期：2018-01-01 00:00:00