Abstract:
:Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error-related negativity) linked to anterior mid-cingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Kuhn J,Gründler TO,Bauer R,Huff W,Fischer AG,Lenartz D,Maarouf M,Bührle C,Klosterkötter J,Ullsperger M,Sturm Vdoi
10.1111/j.1369-1600.2011.00337.xsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
620-3issue
4eissn
1355-6215issn
1369-1600journal_volume
16pub_type
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