Abstract：
:Voluntary oral ethanol consumption in rodents is generally limited by strong taste-aversion in these species. Historically, this has been overcome by combining ethanol with a sweetener, typically sucrose or saccharine, and then slowly 'fading' away the sweetener. While useful in most instances, this approach has not proven as successful for some inbred strains of mice (e.g. DBA/2J) despite consistent evidence in the literature that these same strains express strong conditioned place preference for intraperitoneal- or intragastric-administered ethanol. Importantly, DBA/2J mice express a polymorphism in a 'sweet' taste receptor subunit gene that reduces the potency of sweet substances in these mice. We hypothesized that the presence of this polymorphism might help explain the contrasting behavioral findings of weak voluntary oral ethanol consumption following sucrose-fade yet robust conditioned place preference for ethanol in this strain. To test this, we compared ethanol consumption initiated by either a 'traditional' sucrose-fade or a fade from an alternative tastant, monosodium glutamate (MSG). We found that in both C57BL/6J and DBA/2J mice, the MSG-fade produced robust increases in home cage ethanol consumption relative to the traditional sucrose-fade. This increased ethanol intake following MSG-fade was evident across a range of ethanol concentrations. Our findings suggest the potential utility of the MSG-fade to establish stable voluntary oral ethanol consumption in mice, particularly ethanol 'non-preferring' strains such as DBA/2J and lend additional support to the notion that ethanol consumption in DBA/2J mice is limited by pronounced taste aversion.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
McCool BA,Chappell AMdoi
10.1111/j.1369-1600.2010.00260.xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
121-31issue
1eissn
1355-6215issn
1369-1600journal_volume
17pub_type
杂志文章abstract：:Recent studies in animal models have shown that the nociceptin system, comprising nociceptin (or OFQ/N, encoded by PNOC) and the nociceptin receptor (an opioid receptor-like protein encoded by OPRL1), may be involved in alcohol and other drug reward pathways. To determine whether the nociceptin system is associated wi...
journal_title：Addiction biology
pub_type： 杂志文章,多中心研究
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abstract：:Intravenous drug addiction is known to be associated with an inordinate morbidity and mortality. As our previous report had identified an immune phenotype consistent with accelerated ageing, we wished to investigate how much of this change may have been related to chronic viral hepatitis. A total of 12 409 clinical pa...
journal_title：Addiction biology
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doi：10.1111/j.1369-1600.2008.00123.x
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journal_title：Addiction biology
pub_type： 杂志文章,评审
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12441
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journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2009.00146.x
更新日期：2009-04-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12146
更新日期：2015-05-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210020077046
更新日期：2001-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12038
更新日期：2013-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12779
更新日期：2020-07-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12703
更新日期：2020-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2012.00488.x
更新日期：2014-05-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219772859
更新日期：1997-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章,评审
doi：10.1080/1355621021000005937
更新日期：2002-10-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12110
更新日期：2015-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12706
更新日期：2020-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12560
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
abstract：:Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
abstract：:Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
abstract：:Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Addiction biology
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更新日期：2020-01-01 00:00:00
abstract：:The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim, male and female C57BL/6J mice (n = 60 per sex) were exposed to the drinking in the dark (DID) model for 4 weeks (DID-1 to DID-4). Dose-response effects of CBD on t...
journal_title：Addiction biology
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更新日期：2020-05-01 00:00:00
abstract：:Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psych...
journal_title：Addiction biology
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