Abstract：
:The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that controls global protein synthesis, in part, by modulating translation initiation, a rate-limiting step for many mRNAs. Previous studies implicate mTOR in regulating stimulant-induced sensitization and antidepressive-like behavior in rodents, as well as drug craving in abstinent heroin addicts. To determine if signaling downstream of mTOR is affected by repeated cocaine administration in reward-associated brain regions, and if inhibition of mTOR alters cocaine-induced behavioral plasticity, C57BL/6J mice received four intraperitoneal (i.p.) injections of 15 mg/kg cocaine and levels of phosphorylated P70S6 kinase and ribosomal S6 protein-two translational regulators directly downstream of mTOR-were analyzed by immunoblotting across several brain regions. Cocaine place preference and locomotor sensitization were elicited by four pairings of cocaine with a distinct environment and the effects of mTOR inhibition were assessed by pre-treating the mice with 10 mg/kg rapamycin, 1 hour prior to: (1) each saline/cocaine conditioning session; (2) a post-conditioning test; or (3) a test for locomotor sensitization conducted at 3 weeks withdrawal. While systemic pre-treatment with 10 mg/kg rapamycin during conditioning failed to alter the development of a cocaine place preference or locomotor sensitization, pre-treatment prior to the post-conditioning test attenuated the expression of the place preference. Additionally, rapamycin pre-treatment prior to a cocaine challenge 3 weeks post-conditioning blocked the expression of the sensitized locomotor response. These findings suggest a role for mTOR activity, and perhaps translational control, in the expression of cocaine-induced place preference and locomotor sensitization.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Bailey J,Ma D,Szumlinski KKdoi
10.1111/j.1369-1600.2010.00311.xsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
248-58issue
2eissn
1355-6215issn
1369-1600journal_volume
17pub_type
杂志文章abstract：:Withdrawal from extended-access cocaine self-administration leads to progressive intensification ('incubation') of cocaine craving. After prolonged withdrawal (1-2 months), when craving is high, expression of incubation depends on strengthening of excitatory inputs to medium spiny neurons (MSN) of the nucleus accumben...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12430
更新日期：2017-11-01 00:00:00
abstract：:Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...
journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
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更新日期：2019-09-01 00:00:00
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journal_title：Addiction biology
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更新日期：2000-01-01 00:00:00
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journal_title：Addiction biology
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journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12038
更新日期：2013-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12058
更新日期：2014-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：1999-07-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2001-07-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章,评审
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更新日期：2017-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12558
更新日期：2018-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12234
更新日期：2016-05-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00424.x
更新日期：2013-01-01 00:00:00
abstract：:Cocaine self-administration in rats results in dysfunctional neuroadaptations in the prelimbic (PrL) cortex during early abstinence. Central to these adaptations is decreased phospho-extracellular signal-regulated kinase (p-ERK), which plays a key role in cocaine seeking. Normalizing ERK phosphorylation in the PrL cor...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Addiction biology
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2007.00092.x
更新日期：2008-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210220139523
更新日期：2002-07-01 00:00:00
abstract：:Previous work suggests a role for dopamine D3-like receptors in psychostimulant reinforcement. The development of new compounds acting selectively at dopamine D3 receptors has opened new possibilities to explore the role of these receptors in animal models of psychostimulant dependence. Here we investigated whether th...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2010.00211.x
更新日期：2010-07-01 00:00:00
abstract：:Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2012-05-01 00:00:00
abstract：:The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2010.00299.x
更新日期：2012-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2020-04-23 00:00:00
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journal_title：Addiction biology
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更新日期：1997-10-01 00:00:00
abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...
journal_title：Addiction biology
pub_type： 评论,杂志文章
doi：10.1111/adb.12265
更新日期：2017-01-01 00:00:00
