Abstract:
:We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a monetary gain. Under that condition, relapsers approached the instrumental stimulus, independent of the expected punishment. The failure of inhibiting an aversive stimulus in favor of approaching an appetitive context cue reflects dysfunctional altered learning mechanisms in relapsers. :Pavlovian conditioned cues (CSs) can drive instrumental behavior in alcohol-dependent patients. However, it remains unclear if the influence of Pavlovian CSs might also promote maladaptive decisions that can increase the risk of relapse. We studied 109 abstinent alcohol-dependent patients and 93 controls who completed a Pavlovian-to-instrumental transfer (PIT) paradigm, and assessed patients' subsequent relapse status during a 1-year follow-up. In our PIT task, participants had to collect “good shells” (instrumental approach) or leave “bad shells” (instrumental inhibition) during the presence of money-related Pavlovian CSs or drink-related pictures in the background. Pavlovian CSs indicated either a monetary gain (ie, 1€, 2€), a monetary loss (ie, -1€, −2€) or a neutral stimulus (0€). Drink-related background pictures were either pictures of participants' favorite alcoholic drink or pictures of water. We found that the influence of money-related Pavlovian CSs on instrumental behavior (ie, the PIT effect) was more pronounced in future relapsers compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where the instrumental stimulus required inhibition while a Pavlovian background CS indicated a monetary gain. Under that condition, relapsers approached the instrumental stimulus, independent of the expected punishment. In contrast, we found no difference in PIT between relapsers and abstainers when drink-related background pictures were presented. The failure of inhibiting an aversive stimulus in favor of approaching an appetitive non-alcohol-related context cue might reflect dysfunctional altered learning mechanisms in relapsers. A possible relation to maladaptive decision making that can lead to high-risk situations for relapse is discussed.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Sommer C,Birkenstock J,Garbusow M,Obst E,Schad DJ,Bernhardt N,Huys QM,Wurst FM,Weinmann W,Heinz A,Smolka MN,Zimmermann USdoi
10.1111/adb.12703subject
Has Abstractpub_date
2020-01-01 00:00:00pages
e12703issue
1eissn
1355-6215issn
1369-1600journal_volume
25pub_type
杂志文章abstract::Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combine...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12492
更新日期:2018-01-01 00:00:00
abstract::In keeping with its ability to control the mesoaccumbens dopamine (DA) pathway, the serotonin2C receptor (5-HT2C R) plays a key role in mediating the behavioral and neurochemical effects of drugs of abuse. Studies assessing the influence of 5-HT2C R agonists on cocaine-induced responses have suggested that 5-HT2C Rs c...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12137
更新日期:2015-05-01 00:00:00
abstract::Several studies have emphasized the role of learning in the development of rapid and chronic tolerances. Recently, it was shown that the NMDA antagonists MK-801(dizocilpine) and ketamine block the development of tolerance to ethanol in rats submitted to tilt-plane apparatus. The present study examines the generality o...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219872344
更新日期:1998-01-01 00:00:00
abstract::Hypothalamic orexin/hypocretin (Orx/Hcrt) neurons are thought to mediate both food-reinforced behaviors and behavior motivated by drugs of abuse. However, the relative role of the Orx/Hcrt system in behavior motivated by food versus drugs of abuse remains unclear. This investigation addressed this question by contrast...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12441
更新日期:2018-01-01 00:00:00
abstract::In utero exposure of fetuses to tobacco is associated with reduced birth weight. We hypothesized that this may be due to the toxic effect of carbon monoxide (CO) from tobacco, which has previously been described to damage mitochondria in non-pregnant adult smokers. Maternal peripheral blood mononuclear cells (PBMCs), ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12183
更新日期:2016-01-01 00:00:00
abstract::The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210120056553
更新日期:2001-07-01 00:00:00
abstract::Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inabilit...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12684
更新日期:2020-01-01 00:00:00
abstract::Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-depe...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12234
更新日期:2016-05-01 00:00:00
abstract::Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12595
更新日期:2018-03-01 00:00:00
abstract::The controversy over the relationship between heroin addiction and hepatocellular dysfunction was examined by assay of serum activities of aspartate and alanine aminotransferases, total protein, albumin and globulin in 48 chronic heroin smokers and 33 controls. Biliary secretion in the addicts was compared to controls...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621961000124826
更新日期:1996-01-01 00:00:00
abstract::The neural and genetic factors underlying chronic tolerance to alcohol are currently unclear. The GluN2A N-methyl-D-aspartate receptors (NMDAR) subunit and the NMDAR-anchoring protein PSD-95 mediate acute alcohol intoxication and represent putative mechanisms mediating tolerance. We found that chronic intermittent eth...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12110
更新日期:2015-03-01 00:00:00
abstract::Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12188
更新日期:2015-01-01 00:00:00
abstract::The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are more likely to use alcohol to cope w...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12784
更新日期:2019-09-01 00:00:00
abstract::The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...
journal_title:Addiction biology
pub_type: 杂志文章,随机对照试验
doi:10.1111/adb.12611
更新日期:2019-05-01 00:00:00
abstract::Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00270.x
更新日期:2012-05-01 00:00:00
abstract::Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and funct...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12486
更新日期:2018-01-01 00:00:00
abstract::The effectiveness of using amphetamine isomer ratios to determine individual compliance with a Dexedrine (dexamphetamine, Celltech, Slough, UK) treatment regimen for the maintenance and detoxification from amphetamine abuse has been audited. The calculation of l/d-amphetamine isomer ratios in urine has been shown prev...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210310001646411
更新日期:2003-12-01 00:00:00
abstract::Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12189
更新日期:2016-01-01 00:00:00
abstract::The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971740
更新日期:1999-04-01 00:00:00
abstract::Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210500223769
更新日期:2005-09-01 00:00:00
abstract::Phosphatidylethanol (PEth), a direct ethanol metabolite, is detectable in blood for more than 2 weeks after sustained ethanol intake. Our aim was to assess the usefulness of PEth [comparing sensitivity, specificity and the area under the curve (AUC)] as compared with carbohydrate-deficient transferrin (CDT), gamma-glu...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2006.00040.x
更新日期:2007-03-01 00:00:00
abstract::Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12632
更新日期:2019-07-01 00:00:00
abstract::The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12247
更新日期:2016-05-01 00:00:00
abstract::The genetic and environmental contributions to differences in response to ethanol have been examined widely using inbred strains, selected lines and genetically engineered (transgenic and 'knock-out') animals. In addition, recombinant inbred strains have been used to identify QTLs (chromosomal regions) associated with...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1080/13556210412331308985
更新日期:2005-03-01 00:00:00
abstract::Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621961000125046
更新日期:1996-01-01 00:00:00
abstract::Converging epidemiological studies show that a life-threatening event increases the incidence of posttraumatic stress disorder (PTSD), which carries 30% to 50% comorbidity with substance use disorders (SUDs). Such comorbidity results in greater drug use and poorer treatment outcomes. There is overlap between the endur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12798
更新日期:2020-09-01 00:00:00
abstract::The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00145.x
更新日期:2009-07-01 00:00:00
abstract::Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result of altered gene expression in various brain regions. The present study investigated brain region-specific changes in the pattern and magnitude of gene expression immediately following chronic intermittent ethanol (CIE) exposure...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00357.x
更新日期:2012-03-01 00:00:00
abstract::Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cogn...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12737
更新日期:2020-03-01 00:00:00
abstract::The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00314.x
更新日期:2012-01-01 00:00:00