Abstract:
:The controversy over the relationship between heroin addiction and hepatocellular dysfunction was examined by assay of serum activities of aspartate and alanine aminotransferases, total protein, albumin and globulin in 48 chronic heroin smokers and 33 controls. Biliary secretion in the addicts was compared to controls by assay of serum bilirubin and its conjugated and unconjugated fractions. Serum aminotransferases, total protein, albumin and globulin did not differ significantly between the addict and the control groups (p < 0.05), whereas total bilirubin and its conjugated fraction were significantly higher in the addicts (p < 0.02). The results indicate that chronic abuse of heroin by smoking affects biliary secretion but exercises little influence over hepatocellular function.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Banerjee D,Sarkar NKdoi
10.1080/1355621961000124826subject
Has Abstractpub_date
1996-01-01 00:00:00pages
197-200issue
2eissn
1355-6215issn
1369-1600pii
5NGGX60A9C8WGEGHjournal_volume
1pub_type
杂志文章abstract::Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219871994
更新日期:1998-10-01 00:00:00
abstract::Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12815
更新日期:2020-07-01 00:00:00
abstract::Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspe...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/j.1369-1600.2008.00135.x
更新日期:2009-01-01 00:00:00
abstract::Poor working memory is linked to future risk-taking behaviors. Lifelong risk of habitual drug use is highest in individuals who initiate use in early adolescence. We sought to determine in rats whether juvenile traits, specifically poor working memory and low salivary brain-derived neurotrophic factor (BDNF), are rela...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12535
更新日期:2018-05-01 00:00:00
abstract::Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.13001
更新日期:2021-01-28 00:00:00
abstract::Despite the fact that several data have supported the involvement of the cerebellum in the functional alterations observed after prolonged cocaine use, this brain structure has been traditionally ignored and excluded from the circuitry affected by addictive drugs. In the present study, we investigated the effects of a...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12223
更新日期:2015-09-01 00:00:00
abstract::Betel quid chewing has been claimed to produce a sense of well-being, euphoria, warm sensation of the body, sweating, salivation, palpitation, heightened alertness and increased capacity to work. These effects suggest that betel quid chewing affects predominantly the central and autonomic nervous systems. Several stud...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1080/13556210120091473
更新日期:2002-01-01 00:00:00
abstract::Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin....
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00479.x
更新日期:2013-01-01 00:00:00
abstract::Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12890
更新日期:2020-03-05 00:00:00
abstract::Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00488.x
更新日期:2014-05-01 00:00:00
abstract::The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00145.x
更新日期:2009-07-01 00:00:00
abstract::Several genetic polymorphisms have been reported to be associated with alcohol withdrawal seizures (AWS) and delirium tremens (DT). To replicate and further explore these findings, we investigated the effects of 12 previously reported candidate genetic variations in two groups of alcohol-dependent European Americans w...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2009.00183.x
更新日期:2010-01-01 00:00:00
abstract::The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12946
更新日期:2020-08-14 00:00:00
abstract::Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12802
更新日期:2020-07-01 00:00:00
abstract::Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12042
更新日期:2014-01-01 00:00:00
abstract::Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00443.x
更新日期:2014-01-01 00:00:00
abstract::Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12779
更新日期:2020-07-01 00:00:00
abstract::Although adolescents are a group heavily targeted by the e-cigarette industry, research in cue-reactivity has not previously examined adolescents' behavioral and neural responses to e-cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12510
更新日期:2018-03-01 00:00:00
abstract::The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...
journal_title:Addiction biology
pub_type: 杂志文章,随机对照试验
doi:10.1111/adb.12611
更新日期:2019-05-01 00:00:00
abstract::Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12189
更新日期:2016-01-01 00:00:00
abstract::Voluntary oral ethanol consumption in rodents is generally limited by strong taste-aversion in these species. Historically, this has been overcome by combining ethanol with a sweetener, typically sucrose or saccharine, and then slowly 'fading' away the sweetener. While useful in most instances, this approach has not p...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00260.x
更新日期:2012-01-01 00:00:00
abstract::Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2007.00067.x
更新日期:2007-06-01 00:00:00
abstract::While the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. The focus of the present study is to determine whether genetic variation in the tryptophan hyd...
journal_title:Addiction biology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1369-1600.2006.00005.x
更新日期:2006-03-01 00:00:00
abstract::In keeping with its ability to control the mesoaccumbens dopamine (DA) pathway, the serotonin2C receptor (5-HT2C R) plays a key role in mediating the behavioral and neurochemical effects of drugs of abuse. Studies assessing the influence of 5-HT2C R agonists on cocaine-induced responses have suggested that 5-HT2C Rs c...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12137
更新日期:2015-05-01 00:00:00
abstract::Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cogn...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12737
更新日期:2020-03-01 00:00:00
abstract::Alcohol exposure during fetal and early postnatal development can lead to an increased incidence of later life adult-onset diseases. Examples include central nervous system dysfunction, depression, anxiety, hyperactivity, and an inability to deal with stressful situations, increased infection and cancer. Direct effect...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12186
更新日期:2016-01-01 00:00:00
abstract::Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210412331292578
更新日期:2004-09-01 00:00:00
abstract::The neural and genetic factors underlying chronic tolerance to alcohol are currently unclear. The GluN2A N-methyl-D-aspartate receptors (NMDAR) subunit and the NMDAR-anchoring protein PSD-95 mediate acute alcohol intoxication and represent putative mechanisms mediating tolerance. We found that chronic intermittent eth...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12110
更新日期:2015-03-01 00:00:00
abstract::Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12558
更新日期:2018-09-01 00:00:00
abstract::Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the bra...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12718
更新日期:2020-01-01 00:00:00