Differential role of hypothalamic orexin/hypocretin neurons in reward seeking motivated by cocaine versus palatable food.

abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...

journal_title：Addiction biology

authors： Tam PG

更新日期：2017-01-01 00:00:00

abstract：:Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...

journal_title：Addiction biology

authors： Lydon-Staley DM,MacLean RR,Falk EB,Bassett DS,Wilson SJ

更新日期：2021-01-28 00:00:00

abstract：:Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...

journal_title：Addiction biology

authors： Ehinger Y,Phamluong K,Darevesky D,Welman M,Moffat JJ,Sakhai SA,Whiteley EL,Berger AL,Laguesse S,Farokhnia M,Leggio L,Lordkipanidzé M,Ron D

更新日期：2020-03-05 00:00:00

abstract：:Smoking-related cues elicit craving and mesocorticolimbic brain activation in smokers. Severity of nicotine dependence seems to moderate cue reactivity, but the direction and mechanisms of its influence remains unclear. Although tobacco control policies demand a ban on tobacco advertising, cue reactivity studies in sm...

journal_title：Addiction biology

authors： Vollstädt-Klein S,Kobiella A,Bühler M,Graf C,Fehr C,Mann K,Smolka MN

更新日期：2011-01-01 00:00:00

abstract：:This review article discusses the importance of identifying gene-environment interactions for understanding the etiology and course of alcohol use disorders and related conditions. A number of critical challenges are discussed, including the fact that there is no organizing typology for classifying different types of ...

journal_title：Addiction biology

authors： Sher KJ,Dick DM,Crabbe JC,Hutchison KE,O'Malley SS,Heath AC

更新日期：2010-04-01 00:00:00

abstract：:Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...

journal_title：Addiction biology

authors： Rolland B,Dricot L,Creupelandt C,Maurage P,De Timary P

更新日期：2020-03-01 00:00:00

abstract：:The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...

journal_title：Addiction biology

authors： Gamaleddin I,Wertheim C,Zhu AZ,Coen KM,Vemuri K,Makryannis A,Goldberg SR,Le Foll B

更新日期：2012-01-01 00:00:00

abstract：:In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of 'Pathological Gambling' ('PG'). Some academic opinion favors leaving PG in the 'Impulse Control Disorder' ('ICD') category, as in ICD-10, whereas others a...

journal_title：Addiction biology

authors： Fauth-Bühler M,Mann K,Potenza MN

更新日期：2017-07-01 00:00:00

abstract：:We demonstrated that the genotype of the variable number tandem repeats (VNTRs) in the linked polymorphic region (LPR) of the 5' promoter and in the intron 2 (Stin2) transcriptional regulatory domains of the serotonin transporter SLC6A4 gene determined its promoter interactions with transcription factors and co-activa...

journal_title：Addiction biology

authors： Vasiliou SA,Ali FR,Haddley K,Cardoso MC,Bubb VJ,Quinn JP

更新日期：2012-01-01 00:00:00

abstract：:Chronic and excessive alcohol consumption induces defined myocardial lesions characterized by impaired structural, mechanical and biochemical features. The pathogenic mechanisms are unknown, although it is possible that protein adduct formation by reactive metabolites of ethanol may be a contributory process. Hitherto...

journal_title：Addiction biology

authors： Worrall S,Richardson PJ,Preedy VR

更新日期：2000-10-01 00:00:00

abstract：:Impulsive delayed reward discounting (DRD) is an important behavioral process in alcohol use disorders (AUDs), reflecting incapacity to delay gratification. Recent work in neuroeconomics has begun to unravel the neural mechanisms supporting DRD, but applications of neuroeconomics in relation to AUDs have been limited....

journal_title：Addiction biology

authors： Amlung M,Sweet LH,Acker J,Brown CL,MacKillop J

更新日期：2014-07-01 00:00:00

abstract：:The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = ...

journal_title：Addiction biology

authors： Schneider U,Paetzold W,Eronat V,Huber TJ,Seifert J,Wiese B,Emrich HM

更新日期：2000-01-01 00:00:00

abstract：:The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The...

journal_title：Addiction biology

authors： Vinod KY,Maccioni P,Garcia-Gutierrez MS,Femenia T,Xie S,Carai MA,Manzanares J,Cooper TB,Hungund BL,Colombo G

更新日期：2012-01-01 00:00:00

abstract：:Cigarette smoke is a major risk factor for both coronary heart disease and peripheral vascular disease and has been reported to contain many oxidizing agents that lead to generation of free radicals. In this study, we investigated the levels of lipid peroxides (LPO) and antioxidant vitamins (C and E), total thiol cont...

journal_title：Addiction biology

authors： Gökkusu C,Ademoglu E,Tamer S,Alkan G

更新日期：2001-09-01 00:00:00

abstract：:Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...

journal_title：Addiction biology

authors： de Miguel E,Vekovischeva O,Kuokkanen K,Vesajoki M,Paasikoski N,Kaskinoro J,Myllymäki M,Lainiola M,Janhunen SK,Hyytiä P,Linden AM,Korpi ER

更新日期：2019-11-01 00:00:00

abstract：:Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and funct...

journal_title：Addiction biology

authors： Kaarre O,Kallioniemi E,Könönen M,Tolmunen T,Kekkonen V,Kivimäki P,Heikkinen N,Ferreri F,Laukkanen E,Määttä S

更新日期：2018-01-01 00:00:00

abstract：:Withdrawal from extended-access cocaine self-administration leads to progressive intensification ('incubation') of cocaine craving. After prolonged withdrawal (1-2 months), when craving is high, expression of incubation depends on strengthening of excitatory inputs to medium spiny neurons (MSN) of the nucleus accumben...

journal_title：Addiction biology

authors： Purgianto A,Weinfeld ME,Wolf ME

更新日期：2017-11-01 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CU...

journal_title：Addiction biology

authors： Hindocha C,Freeman TP,Schafer G,Gardner C,Bloomfield MAP,Bramon E,Morgan CJA,Curran HV

更新日期：2020-05-01 00:00:00

abstract：:The rate of acetaldehyde metabolism was measured in aortic rings from rat strains genetically bred for high (UChB) and low (UChA) voluntary ethanol consumption. The results show that in aortic rings from naive UChB rats, acetaldehyde oxidation rates were significantly greater than the rates observed in aortic rings fr...

journal_title：Addiction biology

authors： Quintanilla ME,Tampier L

更新日期：1999-01-01 00:00:00

abstract：:Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their influence on cocaine-dependent behavioral and neuronal plasticity has not been explained. In this s...

journal_title：Addiction biology

authors： Mongi-Bragato B,Zamponi E,García-Keller C,Assis MA,Virgolini MB,Mascó DH,Zimmer A,Cancela LM

更新日期：2016-03-01 00:00:00

abstract：:Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...

journal_title：Addiction biology

authors： Bellentani S,Saccoccio G,Masutti F,Giacca M,Miglioli L,Monzoni A,Tiribelli C

更新日期：2000-07-01 00:00:00

abstract：:The effectiveness of using amphetamine isomer ratios to determine individual compliance with a Dexedrine (dexamphetamine, Celltech, Slough, UK) treatment regimen for the maintenance and detoxification from amphetamine abuse has been audited. The calculation of l/d-amphetamine isomer ratios in urine has been shown prev...

journal_title：Addiction biology

authors： George S

更新日期：2003-12-01 00:00:00

abstract：:The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consum...

journal_title：Addiction biology

authors： Suchankova P,Nilsson S,von der Pahlen B,Santtila P,Sandnabba K,Johansson A,Jern P,Engel JA,Jerlhag E

更新日期：2016-03-01 00:00:00

abstract：:Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in the treatment of drug dependence and drug withdrawal. Oxytocin reduces methamphetamine self-administration, conditioned place preference and hyperactivity in rodents. However, it is unclear how oxytocin acts in the brain to prod...

journal_title：Addiction biology

authors： Carson DS,Hunt GE,Guastella AJ,Barber L,Cornish JL,Arnold JC,Boucher AA,McGregor IS

更新日期：2010-10-01 00:00:00

abstract：:Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide. These mushrooms represent a growing problem regarding hallucinogenic drug abuse. Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocy...

journal_title：Addiction biology

authors： Passie T,Seifert J,Schneider U,Emrich HM

更新日期：2002-10-01 00:00:00

abstract：:Nicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers' brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers'. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors ma...

journal_title：Addiction biology

authors： Das D,Cherbuin N,Anstey KJ,Sachdev PS,Easteal S

更新日期：2012-07-01 00:00:00

abstract：:It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subje...

journal_title：Addiction biology

authors： Loeber S,Vollstädt-Klein S,von der Goltz C,Flor H,Mann K,Kiefer F

更新日期：2009-04-01 00:00:00

abstract：:Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...

journal_title：Addiction biology

authors： Loftén A,Adermark L,Ericson M,Söderpalm B

更新日期：2020-08-13 00:00:00

abstract：:The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...

journal_title：Addiction biology

authors： Wolff CB,Peters TJ,Keating J,Gardner WN

更新日期：1999-04-01 00:00:00