Prolonged withdrawal from cocaine self-administration affects prefrontal cortex- and basolateral amygdala-nucleus accumbens core circuits but not accumbens GABAergic local interneurons.

abstract：:A major finding--that (-)-trans-Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB(1) and CB(2), and that...

journal_title：Addiction biology

authors： Pertwee RG

更新日期：2008-06-01 00:00:00

abstract：:Based on the knowledge that alcohol misuse causes a multitude of diseases and increased mortality, this systematic review examines whether a reduction of the individual alcohol consumption can contribute to a minimization of health risks within a harm reduction approach. In fact, the reviewed 63 studies indicate that ...

journal_title：Addiction biology

authors： Charlet K,Heinz A

更新日期：2017-09-01 00:00:00

abstract：:Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...

journal_title：Addiction biology

authors： Pavon FJ,Serrano A,Sidhpura N,Polis I,Stouffer D,de Fonseca FR,Cravatt BF,Martin-Fardon R,Parsons LH

更新日期：2018-03-01 00:00:00

abstract：:Abuse of Δ⁹-THC by females during adolescence may produce long-term deficits in complex behavioral processes such as learning, and these deficits may be affected by the presence of ovarian hormones. To assess this possibility, 40 injections of saline or 5.6 mg/kg of Δ⁹-THC were administered i.p. daily during adolescen...

journal_title：Addiction biology

authors： Winsauer PJ,Daniel JM,Filipeanu CM,Leonard ST,Hulst JL,Rodgers SP,Lassen-Greene CL,Sutton JL

更新日期：2011-01-01 00:00:00

abstract：:The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...

journal_title：Addiction biology

authors： Gamaleddin I,Wertheim C,Zhu AZ,Coen KM,Vemuri K,Makryannis A,Goldberg SR,Le Foll B

更新日期：2012-01-01 00:00:00

abstract：:Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combine...

journal_title：Addiction biology

authors： Yip SW,Worhunsky PD,Xu J,Morie KP,Constable RT,Malison RT,Carroll KM,Potenza MN

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neur...

journal_title：Addiction biology

authors： Chu NN,Xia W,Yu P,Hu L,Zhang R,Cui CL

更新日期：2008-03-01 00:00:00

abstract：:Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...

journal_title：Addiction biology

authors： Schote AB,Jäger K,Kroll SL,Vonmoos M,Hulka LM,Preller KH,Meyer J,Grünblatt E,Quednow BB

更新日期：2019-07-01 00:00:00

abstract：:Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...

journal_title：Addiction biology

authors： Lenz B,Mühle C,Cohort Study on Substance Use Risk Factors.,Kornhuber J

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or hi...

journal_title：Addiction biology

authors： Morley KC,Lagopoulos J,Logge W,Baillie A,Adams C,Haber PS

更新日期：2020-01-01 00:00:00

abstract：:Previous work suggests a role for dopamine D3-like receptors in psychostimulant reinforcement. The development of new compounds acting selectively at dopamine D3 receptors has opened new possibilities to explore the role of these receptors in animal models of psychostimulant dependence. Here we investigated whether th...

journal_title：Addiction biology

authors： Orio L,Wee S,Newman AH,Pulvirenti L,Koob GF

更新日期：2010-07-01 00:00:00

abstract：:Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-depe...

journal_title：Addiction biology

authors： Zhang R,Jiang G,Tian J,Qiu Y,Wen X,Zalesky A,Li M,Ma X,Wang J,Li S,Wang T,Li C,Huang R

更新日期：2016-05-01 00:00:00

abstract：:The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...

journal_title：Addiction biology

authors： Herman AI,Conner TS,Anton RF,Gelernter J,Kranzler HR,Covault J

更新日期：2011-01-01 00:00:00

abstract：:Animal research supports a central role for corticotropin-releasing factor (CRF) in actions of ethanol on brain function. An examination of alcohol consumption in adolescents reported a significant genotype x environment (G x E) interaction involving rs1876831, a corticotropin-releasing hormone receptor 1 (CRHR1) poly...

journal_title：Addiction biology

authors： Nelson EC,Agrawal A,Pergadia ML,Wang JC,Whitfield JB,Saccone FS,Kern J,Grant JD,Schrage AJ,Rice JP,Montgomery GW,Heath AC,Goate AM,Martin NG,Madden PA

更新日期：2010-01-01 00:00:00

abstract：:Withdrawal of opioid drugs leads to a cluster of unpleasant symptoms in dependent subjects. These symptoms are stimulatory in nature and oppose the acute, inhibitory effects of opiates. The conventional theory that explains the opioid withdrawal syndrome assumes that chronic usage of opioid drugs activates compensator...

journal_title：Addiction biology

authors： Rubovitch V,Pick CG,Sarne Y

更新日期：2009-09-01 00:00:00

abstract：:Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in the treatment of drug dependence and drug withdrawal. Oxytocin reduces methamphetamine self-administration, conditioned place preference and hyperactivity in rodents. However, it is unclear how oxytocin acts in the brain to prod...

journal_title：Addiction biology

authors： Carson DS,Hunt GE,Guastella AJ,Barber L,Cornish JL,Arnold JC,Boucher AA,McGregor IS

更新日期：2010-10-01 00:00:00

abstract：:It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic r...

journal_title：Addiction biology

authors： Owens MM,MacKillop J,Gray JC,Beach SRH,Stein MD,Niaura RS,Sweet LH

更新日期：2018-09-01 00:00:00

abstract：:Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...

journal_title：Addiction biology

authors： Lidö HH,Marston H,Ericson M,Söderpalm B

更新日期：2012-09-01 00:00:00

abstract：:We examined whether acute administration of phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate (NMDA) receptor-channel complex, can cause neuronal toxicity that is associated with apoptosis. Three- and 24-month-old rats were placed in locomotor activity chambers. PCP (50 mg/kg) or saline (0.15 M NaCl) were...

journal_title：Addiction biology

authors： Milosević J,Veskov R,Vasilev V,Rakić L,Ruzdijić S

更新日期：2000-04-01 00:00:00

abstract：:Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...

journal_title：Addiction biology

authors： Martín-García E,Fernández-Castillo N,Burokas A,Gutiérrez-Cuesta J,Sánchez-Mora C,Casas M,Ribasés M,Cormand B,Maldonado R

更新日期：2015-01-01 00:00:00

abstract：:Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor increasing vulnerability involves reduced expression of the serotonin transporter (5-HTT). Human s...

journal_title：Addiction biology

authors： Karel P,Van der Toorn A,Vanderschuren L,Guo C,Sadighi Alvandi M,Reneman L,Dijkhuizen R,Verheij MMM,Homberg JR

更新日期：2020-01-01 00:00:00

abstract：:Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...

journal_title：Addiction biology

authors： Rolland B,Dricot L,Creupelandt C,Maurage P,De Timary P

更新日期：2020-03-01 00:00:00

abstract：:In utero exposure of fetuses to tobacco is associated with reduced birth weight. We hypothesized that this may be due to the toxic effect of carbon monoxide (CO) from tobacco, which has previously been described to damage mitochondria in non-pregnant adult smokers. Maternal peripheral blood mononuclear cells (PBMCs), ...

journal_title：Addiction biology

authors： Garrabou G,Hernàndez AS,Catalán García M,Morén C,Tobías E,Córdoba S,López M,Figueras F,Grau JM,Cardellach F

更新日期：2016-01-01 00:00:00

abstract：:Betel quid chewing has been claimed to produce a sense of well-being, euphoria, warm sensation of the body, sweating, salivation, palpitation, heightened alertness and increased capacity to work. These effects suggest that betel quid chewing affects predominantly the central and autonomic nervous systems. Several stud...

journal_title：Addiction biology

authors： Chu NS

更新日期：2002-01-01 00:00:00

abstract：:The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...

journal_title：Addiction biology

authors： Fragale JE,James MH,Aston-Jones G

更新日期：2020-08-14 00:00:00

abstract：:Combined anorectic-alcohol misuse is a prevalent problem in Brazil. In order to understand better the interactive effects of ethanol (EtOH) and mazindol (MZ), we examined the effects of EtOH (1.2 g/kg) and MZ (5.0 mg/kg) given alone or in combination, on mouse behaviour. The results indicate that EtOH plus MZ induces ...

journal_title：Addiction biology

authors： Gevaerd MS,Takahashi RN

更新日期：1996-01-01 00:00:00

abstract：:Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...

journal_title：Addiction biology

authors： Teichtahl H,Wang D,Cunnington D,Kronborg I,Goodman C,Prodromidis A,Drummer O

更新日期：2004-09-01 00:00:00

abstract：:The technique of domiciliary rapid opiate detoxification (ROD) developed in Asturias since 1994 enables patients dependent on heroin and/or methadone (or other opiates) to start antagonist maintenance with a full dose of naltrexone (50 mg) and largely recover from the acute opiate withdrawal syndrome in a few hours at...

journal_title：Addiction biology

authors： Carreño JE,Bobes J,Brewer C,Alvarez CE,San Narciso GI,Bascarán MT,Sánchez del Río J

更新日期：2002-04-01 00:00:00

abstract：:Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...

journal_title：Addiction biology

authors： Solecki WB,Szklarczyk K,Pradel K,Kwiatkowska K,Dobrzański G,Przewłocki R

更新日期：2018-03-01 00:00:00

abstract：:Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of ...

journal_title：Addiction biology

authors： Gamaleya N,Tronnikov S,Ulyanova L,Klimova S,Dmitrieva I

更新日期：1996-01-01 00:00:00