Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats.


:The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The effects of acquisition and maintenance of alcohol drinking, alcohol withdrawal, and alcohol re-exposure on the endocannabinoid system was also assessed in the striatum of sP rats. The findings revealed significantly higher density of the CB1 receptors and levels of CB1 receptor mRNA, CB1 receptor-mediated G-protein coupling, and endocannabinoids in the cerebral cortex, hippocampus and striatum of alcohol-naive sP rats than sNP rats. A significantly lower expression of mFAAH enzyme was evident in the hippocampus of alcohol-naive sP rats. Alcohol drinking (during both acquisition and maintenance phases) in sP rats resulted in a significant reduction in striatal CB1 receptor-mediated G-protein coupling whereas alcohol withdrawal attenuated this effect. Alcohol consumption was also associated with markedly increased levels of endocannabinoids in the striatum. Co-administration of the CB1 receptor antagonist, rimonabant (SR141716A) reduced alcohol intake, and reversed alcohol-induced changes in CB1 receptor-mediated G-protein activation. These findings provided a new insight into a potential genetic basis of excessive alcohol consumption, suggesting innate differences in the endocannabinoid system might be associated with higher alcohol preference in sP rats. The data also indicate a modulation of CB1 receptor-mediated signaling following alcohol consumption, and further strengthen the potential of the endocannabinoid system as a target for the treatment of alcohol related behaviors.


Addict Biol


Addiction biology


Vinod KY,Maccioni P,Garcia-Gutierrez MS,Femenia T,Xie S,Carai MA,Manzanares J,Cooper TB,Hungund BL,Colombo G




Has Abstract


2012-01-01 00:00:00












  • Risk factors for alcoholic liver disease.

    abstract::Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Bellentani S,Saccoccio G,Masutti F,Giacca M,Miglioli L,Monzoni A,Tiribelli C

    更新日期:2000-07-01 00:00:00

  • Cocaine addiction is associated with abnormal prefrontal function, increased striatal connectivity and sensitivity to monetary incentives, and decreased connectivity outside the human reward circuit.

    abstract::Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Vaquero L,Cámara E,Sampedro F,Pérez de Los Cobos J,Batlle F,Fabregas JM,Sales JA,Cervantes M,Ferrer X,Lazcano G,Rodríguez-Fornells A,Riba J

    更新日期:2017-05-01 00:00:00

  • Gray-matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions.

    abstract::Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combine...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Yip SW,Worhunsky PD,Xu J,Morie KP,Constable RT,Malison RT,Carroll KM,Potenza MN

    更新日期:2018-01-01 00:00:00

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Liu L,Yip SW,Zhang JT,Wang LJ,Shen ZJ,Liu B,Ma SS,Yao YW,Fang XY

    更新日期:2017-05-01 00:00:00

  • Allergic and asthmatic reactions to alcoholic drinks.

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    journal_title:Addiction biology

    pub_type: 杂志文章,评审


    authors: Vally H,Thompson PJ

    更新日期:2003-03-01 00:00:00

  • The cerebellum on cocaine: plasticity and metaplasticity.

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Vazquez-Sanroman D,Leto K,Cerezo-Garcia M,Carbo-Gas M,Sanchis-Segura C,Carulli D,Rossi F,Miquel M

    更新日期:2015-09-01 00:00:00

  • Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization.

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Bailey J,Ma D,Szumlinski KK

    更新日期:2012-03-01 00:00:00

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    abstract::It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic r...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Owens MM,MacKillop J,Gray JC,Beach SRH,Stein MD,Niaura RS,Sweet LH

    更新日期:2018-09-01 00:00:00

  • Adolescents' behavioral and neural responses to e-cigarette advertising.

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Chen Y,Fowler CH,Papa VB,Lepping RJ,Brucks MG,Fox AT,Martin LE

    更新日期:2018-03-01 00:00:00

  • Preliminary evidence of different and clinically meaningful opioid withdrawal phenotypes.

    abstract::Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Dunn KE,Weerts EM,Huhn AS,Schroeder JR,Tompkins DA,Bigelow GE,Strain EC

    更新日期:2020-01-01 00:00:00

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    abstract::The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = ...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Schneider U,Paetzold W,Eronat V,Huber TJ,Seifert J,Wiese B,Emrich HM

    更新日期:2000-01-01 00:00:00

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    abstract::The AA (alko, alcohol) and ANA (alko, non-alcohol) rat lines were among the earliest rodent lines produced by bidirectional selection for ethanol preference. The purpose of this review is to highlight the strategies for understanding the neurobiological factors underlying differential alcohol-drinking behavior in thes...

    journal_title:Addiction biology

    pub_type: 杂志文章,评审


    authors: Sommer W,Hyytiä P,Kiianmaa K

    更新日期:2006-09-01 00:00:00

  • Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder.

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Zhang JT,Yao YW,Li CS,Zang YF,Shen ZJ,Liu L,Wang LJ,Liu B,Fang XY

    更新日期:2016-05-01 00:00:00

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Purgianto A,Weinfeld ME,Wolf ME

    更新日期:2017-11-01 00:00:00

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    journal_title:Addiction biology

    pub_type: 杂志文章,评审


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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Dodd PR,Eckert AL,Fletcher LM,Kril JJ,Harper CG,Halliday JW

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    journal_title:Addiction biology

    pub_type: 评论,杂志文章


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    更新日期:2017-01-01 00:00:00

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    abstract::The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: McLachlan-Troup N,Taylor GW,Trathen BC

    更新日期:2001-07-01 00:00:00

  • Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition.

    abstract::Smoking withdrawal is associated with significant deficits in the ability to initiate and maintain attention for extended periods of time (i.e. sustained attention; SA). However, the effects of smoking abstinence on the temporal dynamics of neurocognition during SA have not been evaluated. Twenty adult smokers underwe...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Kozink RV,Lutz AM,Rose JE,Froeliger B,McClernon FJ

    更新日期:2010-10-01 00:00:00

  • Long-term haloperidol treatment (but not risperidone) enhances addiction-related behaviors in mice: role of dopamine D2 receptors.

    abstract::The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Carvalho RC,Fukushiro DF,Helfer DC,Callegaro-Filho D,Trombin TF,Zanlorenci LH,Sanday L,Silva RH,Frussa-Filho R

    更新日期:2009-07-01 00:00:00

  • Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization.

    abstract::Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their influence on cocaine-dependent behavioral and neuronal plasticity has not been explained. In this s...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Mongi-Bragato B,Zamponi E,García-Keller C,Assis MA,Virgolini MB,Mascó DH,Zimmer A,Cancela LM

    更新日期:2016-03-01 00:00:00

  • Pulling habits out of rats: adenosine 2A receptor antagonism in dorsomedial striatum rescues meth-amphetamine-induced deficits in goal-directed action.

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    journal_title:Addiction biology

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    authors: Furlong TM,Supit AS,Corbit LH,Killcross S,Balleine BW

    更新日期:2017-01-01 00:00:00

  • Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats.

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Wu Y,Li Y,Yang X,Sui N

    更新日期:2014-01-01 00:00:00

  • Modification of pharmacokinetic and abuse-related effects of cocaine by human-derived cocaine hydrolase in monkeys.

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Schindler CW,Justinova Z,Lafleur D,Woods D,Roschke V,Hallak H,Sklair-Tavron L,Redhi GH,Yasar S,Bergman J,Goldberg SR

    更新日期:2013-01-01 00:00:00

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    journal_title:Addiction biology

    pub_type: 杂志文章,评审


    authors: McKee SA

    更新日期:2009-01-01 00:00:00

  • The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice.

    abstract::Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Kim M,Custodio RJ,Botanas CJ,de la Peña JB,Sayson LV,Abiero A,Ryoo ZY,Cheong JH,Kim HJ

    更新日期:2019-09-01 00:00:00

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Siemsen BM,Lombroso PJ,McGinty JF

    更新日期:2018-01-01 00:00:00

  • Frustrated expected reward induces differential transcriptional changes in the mouse brain.

    abstract::Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Martín-García E,Fernández-Castillo N,Burokas A,Gutiérrez-Cuesta J,Sánchez-Mora C,Casas M,Ribasés M,Cormand B,Maldonado R

    更新日期:2015-01-01 00:00:00

  • Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring.

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Kuhn J,Gründler TO,Bauer R,Huff W,Fischer AG,Lenartz D,Maarouf M,Bührle C,Klosterkötter J,Ullsperger M,Sturm V

    更新日期:2011-10-01 00:00:00

  • Release of neurotransmitters from rat brain nerve terminals after chronic ethanol ingestion: differential effects in cortex and hippocampus.

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    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Sabriá J,Torres D,Pastó M,Peralba JM,Allali-Hassani A,Parés X

    更新日期:2003-09-01 00:00:00