Abstract：
:This review article discusses the importance of identifying gene-environment interactions for understanding the etiology and course of alcohol use disorders and related conditions. A number of critical challenges are discussed, including the fact that there is no organizing typology for classifying different types of environmental exposures, many key human environmental risk factors for alcohol dependence have no clear equivalents in other species, much of the genetic variance of alcohol dependence in human is not 'alcohol specific', and the potential range of gene-environment interactions that could be considered is so vast that maintaining statistical control of Type 1 errors is a daunting task. Despite these and other challenges, there appears to be a number of promising approaches that could be taken in order to achieve consilience and ecologically valid translation between human alcohol dependence and animal models. Foremost among these is to distinguish environmental exposures that are thought to have enduring effects on alcohol use motivation (and self-regulation) from situational environmental exposures that facilitate the expression of such motivations but do not, by themselves, have enduring effects. In order to enhance consilience, various domains of human approach motivation should be considered so that relevant environmental exposures can be sampled, as well as the appropriate species to study them in (i.e. where such motivations are ecologically relevant). Foremost among these are social environments, which are central to the initiation and escalation of human alcohol consumption. The value of twin studies, human laboratory studies and pharmacogenetic studies is also highlighted.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Sher KJ,Dick DM,Crabbe JC,Hutchison KE,O'Malley SS,Heath ACdoi
10.1111/j.1369-1600.2009.00189.xsubject
Has Abstractpub_date
2010-04-01 00:00:00pages
200-16issue
2eissn
1355-6215issn
1369-1600pii
ADB189journal_volume
15pub_type
杂志文章,评审abstract：:We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12294
更新日期：2017-01-01 00:00:00
abstract：:Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210500223769
更新日期：2005-09-01 00:00:00
abstract：:Alcoholic drinks are capable of triggering a wide range of allergic and allergic-like responses, including rhinitis, itching, facial swelling, headache, cough and asthma. Limited epidemiological data suggests that many individuals are affected and that sensitivities occur to a variety of drinks, including wine, beer a...
journal_title：Addiction biology
pub_type： 杂志文章,评审
doi：10.1080/1355621031000069828
更新日期：2003-03-01 00:00:00
abstract：:Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219971407
更新日期：1999-10-01 00:00:00
abstract：:The technique of domiciliary rapid opiate detoxification (ROD) developed in Asturias since 1994 enables patients dependent on heroin and/or methadone (or other opiates) to start antagonist maintenance with a full dose of naltrexone (50 mg) and largely recover from the acute opiate withdrawal syndrome in a few hours at...
journal_title：Addiction biology
pub_type： 临床试验,杂志文章
doi：10.1080/135562102200120479
更新日期：2002-04-01 00:00:00
abstract：:Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12338
更新日期：2017-05-01 00:00:00
abstract：:Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12560
更新日期：2018-09-01 00:00:00
abstract：:The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00314.x
更新日期：2012-01-01 00:00:00
abstract：:Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12688
更新日期：2019-11-01 00:00:00
abstract：:In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of 'Pathological Gambling' ('PG'). Some academic opinion favors leaving PG in the 'Impulse Control Disorder' ('ICD') category, as in ICD-10, whereas others a...
journal_title：Addiction biology
pub_type： 杂志文章,评审
doi：10.1111/adb.12378
更新日期：2017-07-01 00:00:00
abstract：:One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice. C57BL/6J mice were trained in operant conditioning maintain...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00423.x
更新日期：2012-07-01 00:00:00
abstract：:The total concentration of THC has been monitored in cannabis preparations sold in Dutch coffee shops since 1999. This annual monitoring was issued by the Ministry of Health after reports of increased potency. The level of the main psychoactive compound, Delta9-tetrahydrocannabinol (THC), is measured in marijuana and ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210500123217
更新日期：2005-06-01 00:00:00
abstract：:Methamphetamine (METH) markedly increases dopamine (DA) release in the mesolimbic DA system, which plays an important role in mediating the reinforcing effects of METH. METH-induced DA release results in the formation of reactive oxygen species (ROS), leading to oxidative damage. We have recently reported that ROS are...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12419
更新日期：2017-09-01 00:00:00
abstract：:Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12189
更新日期：2016-01-01 00:00:00
abstract：:Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12677
更新日期：2019-09-01 00:00:00
abstract：:Early relapse is common after opiate withdrawal and deprives addicts of important opportunities to develop new, opiate-free cognitive-behavioural habits. The oral opiate antagonist naltrexone (NTX) significantly reduces relapse only when rigorously supervised and/or probation-linked. Simple but effective NTX implants,...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/1355621031000117446
更新日期：2003-06-01 00:00:00
abstract：:Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12890
更新日期：2020-03-05 00:00:00
abstract：:Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12514
更新日期：2018-03-01 00:00:00
abstract：:The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210120056553
更新日期：2001-07-01 00:00:00
abstract：:The effectiveness of using amphetamine isomer ratios to determine individual compliance with a Dexedrine (dexamphetamine, Celltech, Slough, UK) treatment regimen for the maintenance and detoxification from amphetamine abuse has been audited. The calculation of l/d-amphetamine isomer ratios in urine has been shown prev...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210310001646411
更新日期：2003-12-01 00:00:00
abstract：:Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12356
更新日期：2017-05-01 00:00:00
abstract：:Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of comp...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12578
更新日期：2019-01-01 00:00:00
abstract：:We examined whether acute administration of phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate (NMDA) receptor-channel complex, can cause neuronal toxicity that is associated with apoptosis. Three- and 24-month-old rats were placed in locomotor activity chambers. PCP (50 mg/kg) or saline (0.15 M NaCl) were...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210050003748
更新日期：2000-04-01 00:00:00
abstract：:This study employs an oral operant conditioning paradigm to evaluate the effects of repeated social defeat during adolescence on the reinforcing and motivational actions of ethanol in adult OF1 mice. Social interaction, emotional and cognitive behavioral aspects were also analyzed, and real-time polymerase chain react...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12184
更新日期：2016-01-01 00:00:00
abstract：:Hypothalamic orexin/hypocretin (Orx/Hcrt) neurons are thought to mediate both food-reinforced behaviors and behavior motivated by drugs of abuse. However, the relative role of the Orx/Hcrt system in behavior motivated by food versus drugs of abuse remains unclear. This investigation addressed this question by contrast...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12441
更新日期：2018-01-01 00:00:00
abstract：:Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be involved in the pathophysiology of several disorders related to smoking and may be relevant for the pathophysiology of nico...
journal_title：Addiction biology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1369-1600.2012.00487.x
更新日期：2014-05-01 00:00:00
abstract：:Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12680
更新日期：2020-01-01 00:00:00
abstract：:Despite the fact that several data have supported the involvement of the cerebellum in the functional alterations observed after prolonged cocaine use, this brain structure has been traditionally ignored and excluded from the circuitry affected by addictive drugs. In the present study, we investigated the effects of a...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12223
更新日期：2015-09-01 00:00:00
abstract：:Adolescent alcohol use is associated with increased risk for alcohol use disorders later in life; therefore, identifying biomarkers for initiation of heavy alcohol use, such as individual differences in the development of white-matter microstructure, may inform prevention strategies that improve public health. This pr...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12767
更新日期：2020-05-01 00:00:00
abstract：:Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational u...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12038
更新日期：2013-09-01 00:00:00
