Abstract:
:One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice. C57BL/6J mice were trained in operant conditioning maintained by chocolate-flavoured pellets or cocaine. After the completion of high rates of responding on a progressive ratio schedule, the reward was unexpectedly withheld. The consequences of this frustrated behaviour on anxiety, aggressiveness, perseveration, extinction and reinstatement were investigated. Mice exposed to the frustrated event perseverated in the operant responses and showed increased aggressiveness in the resident-intruder test. These animals also showed higher rates of cue-induced reinstatement of drug seeking. The present study provides a reliable operant model in mice to evaluate a frustrated state following reward unavailability. This animal model could be useful to study the behavioural and neurochemical consequences related to the emotional states generated during the omission of a highly expected reward.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Burokas A,Gutiérrez-Cuesta J,Martín-García E,Maldonado Rdoi
10.1111/j.1369-1600.2011.00423.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
770-82issue
4eissn
1355-6215issn
1369-1600journal_volume
17pub_type
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pub_type: 杂志文章,随机对照试验
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