Abstract:
:We examined whether acute administration of phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate (NMDA) receptor-channel complex, can cause neuronal toxicity that is associated with apoptosis. Three- and 24-month-old rats were placed in locomotor activity chambers. PCP (50 mg/kg) or saline (0.15 M NaCl) were simultaneously administered to the treated and age-matched controls. After observing changes of locomotor activities, the animals were killed 24 h after treatment. The brains were processed for in situ analysis of apoptosis either by propidium iodide (PI) staining, or for the terminal dUTP nick-end labelling (TUNEL) method. The regional distribution of apoptotic nuclei was established using PI staining. Apoptosis was additionally confirmed and quantified by the TUNEL technique. PI and TUNEL staining revealed that PCP-mediated neurotoxicity in the prefrontal and enthorhinal cortices, the striatum and hippocampus was associated with a significant number of neurons exhibiting apoptotic morphology. We found that the total number of apoptotic cells was higher in the brains of 24-month-old rats. Compared to the respective controls the number of apoptotic cells was 3.8-fold greater in the cortex of old rats, followed by the striatum (three-fold), and hippocampus (1.4-fold). Accordingly, we concluded that ageing was accompanied by DNA-damage that was most pronounced in the prefrontal cortical neurones. The most prominent elevation in the degree of apoptosis in the young-treated compared to young-untreated rats was detected in the striatum. Comparison of the number of TUNEL-positive cells in treated-aged versus treated-young rats revealed that in all the examined regions of the brain PCP exerted a stronger apoptotic effect in younger animals.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Milosević J,Veskov R,Vasilev V,Rakić L,Ruzdijić Sdoi
10.1080/13556210050003748subject
Has Abstractpub_date
2000-04-01 00:00:00pages
157-65issue
2eissn
1355-6215issn
1369-1600pii
ADB157journal_volume
5pub_type
杂志文章abstract::Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12802
更新日期:2020-07-01 00:00:00
abstract::The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971740
更新日期:1999-04-01 00:00:00
abstract::Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971407
更新日期:1999-10-01 00:00:00
abstract::Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12189
更新日期:2016-01-01 00:00:00
abstract::Withdrawal of opioid drugs leads to a cluster of unpleasant symptoms in dependent subjects. These symptoms are stimulatory in nature and oppose the acute, inhibitory effects of opiates. The conventional theory that explains the opioid withdrawal syndrome assumes that chronic usage of opioid drugs activates compensator...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2009.00164.x
更新日期:2009-09-01 00:00:00
abstract::Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspe...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/j.1369-1600.2008.00135.x
更新日期:2009-01-01 00:00:00
abstract::Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing m...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12433
更新日期:2017-11-01 00:00:00
abstract::Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12815
更新日期:2020-07-01 00:00:00
abstract::Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or preven...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12161
更新日期:2015-07-01 00:00:00
abstract::Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational u...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12038
更新日期:2013-09-01 00:00:00
abstract::Phosphatidylethanol (PEth), a direct ethanol metabolite, is detectable in blood for more than 2 weeks after sustained ethanol intake. Our aim was to assess the usefulness of PEth [comparing sensitivity, specificity and the area under the curve (AUC)] as compared with carbohydrate-deficient transferrin (CDT), gamma-glu...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2006.00040.x
更新日期:2007-03-01 00:00:00
abstract::Associations between nicotine in cigarettes and food consumption may alter the incentive value of food such that food cue-reactivity is exaggerated during abstinence from smoking. This effect may contribute to the weight gain associated with cessation of smoking. We examined the effects of nicotine (0.4 mg/kg base sub...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00436.x
更新日期:2012-05-01 00:00:00
abstract::This study investigated the effects of chronic ethanol intake on hepatic haemodynamics and reticuloendothelial system function in the rat. Comparisons were also made with blood flow to pancreas, kidney, spleen, lung and skin. Male Wistar rats, approximately 0.15 kg initial body weight, were fed a diet containing 35% o...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219772507
更新日期:1997-10-01 00:00:00
abstract::Smoking withdrawal is associated with significant deficits in the ability to initiate and maintain attention for extended periods of time (i.e. sustained attention; SA). However, the effects of smoking abstinence on the temporal dynamics of neurocognition during SA have not been evaluated. Twenty adult smokers underwe...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00252.x
更新日期:2010-10-01 00:00:00
abstract::Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00341.x
更新日期:2011-10-01 00:00:00
abstract::Abstract Methamphetamine (METH)-induced dopaminergic neurotoxicity is thought to be associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recently, we have reported that copper/zinc(CuZn)-superoxide dismutase transgenic mice are resistant to METH-induced neurotoxicity. In...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2000.tb00200.x
更新日期:2000-07-01 00:00:00
abstract::Ethanol oxidation to acetaldehyde and next to acetate is accompanied by free radical generation. Free radicals can affect cell integrity when antioxidant mechanisms are no longer able to cope with the free radical generation observed in ethanol intoxication. Natural antioxidants are particularly useful in such a situa...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210220139523
更新日期:2002-07-01 00:00:00
abstract::Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12688
更新日期:2019-11-01 00:00:00
abstract::The Lewis (LEW) and Fischer 344 (F344) inbred rat strains are frequently used to study the role of genetic factors in vulnerability to drug addiction and relapse. Glutamate and γ-amino butyric acid (GABA) transmission are significantly altered after cocaine-induced reinstatement, although whether LEW and F344 rats dif...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00404.x
更新日期:2013-07-01 00:00:00
abstract::Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2000.tb00190.x
更新日期:2000-07-01 00:00:00
abstract::Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subj...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12246
更新日期:2016-05-01 00:00:00
abstract::Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12890
更新日期:2020-03-05 00:00:00
abstract::Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combine...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12492
更新日期:2018-01-01 00:00:00
abstract::Hypothalamic orexin/hypocretin (Orx/Hcrt) neurons are thought to mediate both food-reinforced behaviors and behavior motivated by drugs of abuse. However, the relative role of the Orx/Hcrt system in behavior motivated by food versus drugs of abuse remains unclear. This investigation addressed this question by contrast...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12441
更新日期:2018-01-01 00:00:00
abstract::The drive to eat is regulated by two compensatory brain pathways termed as homeostatic and hedonic. Hypothalamic orexinergic (ORX) neurons regulate metabolism, feeding and reward, thus controlling physiological and hedonic appetite. Circadian regulation of feeding, metabolism and rhythmic activity of ORX cells are dri...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12339
更新日期:2017-03-01 00:00:00
abstract::Chronic and excessive alcohol consumption induces defined myocardial lesions characterized by impaired structural, mechanical and biochemical features. The pathogenic mechanisms are unknown, although it is possible that protein adduct formation by reactive metabolites of ethanol may be a contributory process. Hitherto...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2000.tb00211.x
更新日期:2000-10-01 00:00:00
abstract::Previous studies on acetaldehyde dehydrogenase 2 (ALDH2) focused on drinking behavior or alcoholism because the ALDH2*2 allele protects against the risk of developing alcoholism. The mechanism provides that the ALDH2 gene's protective effect is also involved in dopamine metabolism. The interaction of the ALDH2 gene wi...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00268.x
更新日期:2012-09-01 00:00:00
abstract::It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic r...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12549
更新日期:2018-09-01 00:00:00
abstract::Methamphetamine (METH) markedly increases dopamine (DA) release in the mesolimbic DA system, which plays an important role in mediating the reinforcing effects of METH. METH-induced DA release results in the formation of reactive oxygen species (ROS), leading to oxidative damage. We have recently reported that ROS are...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12419
更新日期:2017-09-01 00:00:00
abstract::Abuse of Δ⁹-THC by females during adolescence may produce long-term deficits in complex behavioral processes such as learning, and these deficits may be affected by the presence of ovarian hormones. To assess this possibility, 40 injections of saline or 5.6 mg/kg of Δ⁹-THC were administered i.p. daily during adolescen...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00227.x
更新日期:2011-01-01 00:00:00