Rev-erbα modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice.

abstract：:Betel quid chewing has been claimed to produce a sense of well-being, euphoria, warm sensation of the body, sweating, salivation, palpitation, heightened alertness and increased capacity to work. These effects suggest that betel quid chewing affects predominantly the central and autonomic nervous systems. Several stud...

journal_title：Addiction biology

authors： Chu NS

更新日期：2002-01-01 00:00:00

abstract：:Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...

journal_title：Addiction biology

authors： Wu Y,Li Y,Yang X,Sui N

更新日期：2014-01-01 00:00:00

abstract：:Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...

journal_title：Addiction biology

authors： Carbo-Gas M,Vazquez-Sanroman D,Aguirre-Manzo L,Coria-Avila GA,Manzo J,Sanchis-Segura C,Miquel M

更新日期：2014-01-01 00:00:00

abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...

journal_title：Addiction biology

authors： Wang JQ,McGinty JF

更新日期：1999-04-01 00:00:00

abstract：:Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...

journal_title：Addiction biology

authors： Palencia G,Calvillo M,Benita A,Sotelo J

更新日期：1998-10-01 00:00:00

abstract：:Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the bra...

journal_title：Addiction biology

authors： Chen J,Liu Q,Fan R,Han H,Yang Z,Cui W,Song G,Li MD

更新日期：2020-01-01 00:00:00

abstract：:The habit of chewing fresh leaves and twigs of khat (Catha edulis) for their stimulating amphetamine-like effects is highly prevalent in East Africa and southwest on the Arabic peninsula. There is an extensive literature on khat providing information about its history, botany, production, geographical distribution, ch...

journal_title：Addiction biology

authors： Al-Hebshi NN,Skaug N

更新日期：2005-12-01 00:00:00

abstract：:Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhe...

journal_title：Addiction biology

authors： Driscoll CA,Lindell SG,Schwandt ML,Suomi SJ,Higley JD,Heilig M,Barr CS

更新日期：2017-11-01 00:00:00

abstract：:Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial ...

journal_title：Addiction biology

authors： Wuo-Silva R,Fukushiro DF,Borçoi AR,Fernandes HA,Procópio-Souza R,Hollais AW,Santos R,Ribeiro LT,Corrêa JM,Talhati F,Saito LP,Aramini TC,Kameda SR,Bittencourt LR,Tufik S,Frussa-Filho R

更新日期：2011-10-01 00:00:00

abstract：:To gain a better insight into the alterations of brain function after chronic ethanol, we measured the release of various neurotransmitters from nerve terminals of cortex and hippocampus isolated fm rats chronically fed with ethanol. The K+-evoked release of [3H]acetylcholine (ACh), f[H]dopamine (DA), [3H] glutamate(G...

journal_title：Addiction biology

authors： Sabriá J,Torres D,Pastó M,Peralba JM,Allali-Hassani A,Parés X

更新日期：2003-09-01 00:00:00

abstract：:Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...

journal_title：Addiction biology

authors： Loftén A,Adermark L,Ericson M,Söderpalm B

更新日期：2020-08-13 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:Adolescent alcohol use is associated with increased risk for alcohol use disorders later in life; therefore, identifying biomarkers for initiation of heavy alcohol use, such as individual differences in the development of white-matter microstructure, may inform prevention strategies that improve public health. This pr...

journal_title：Addiction biology

authors： Morales AM,Jones SA,Harman G,Patching-Bunch J,Nagel BJ

更新日期：2020-05-01 00:00:00

abstract：:Hypothalamic orexin/hypocretin (Orx/Hcrt) neurons are thought to mediate both food-reinforced behaviors and behavior motivated by drugs of abuse. However, the relative role of the Orx/Hcrt system in behavior motivated by food versus drugs of abuse remains unclear. This investigation addressed this question by contrast...

journal_title：Addiction biology

authors： Martin-Fardon R,Cauvi G,Kerr TM,Weiss F

更新日期：2018-01-01 00:00:00

abstract：:This review article discusses the importance of identifying gene-environment interactions for understanding the etiology and course of alcohol use disorders and related conditions. A number of critical challenges are discussed, including the fact that there is no organizing typology for classifying different types of ...

journal_title：Addiction biology

authors： Sher KJ,Dick DM,Crabbe JC,Hutchison KE,O'Malley SS,Heath AC

更新日期：2010-04-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that controls global protein synthesis, in part, by modulating translation initiation, a rate-limiting step for many mRNAs. Previous studies implicate mTOR in regulating stimulant-induced sensitization and antidepressive-like behavior in rodents, as...

journal_title：Addiction biology

authors： Bailey J,Ma D,Szumlinski KK

更新日期：2012-03-01 00:00:00

abstract：:Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dep...

journal_title：Addiction biology

authors： Murray DE,Durazzo TC,Schmidt TP,Murray TA,Abé C,Guydish J,Meyerhoff DJ

更新日期：2018-03-01 00:00:00

abstract：:Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF1 and CRF2 receptor mRNA. Furthermore, the ascending NI relaxin-3 syst...

journal_title：Addiction biology

authors： Walker LC,Kastman HE,Koeleman JA,Smith CM,Perry CJ,Krstew EV,Gundlach AL,Lawrence AJ

更新日期：2017-11-01 00:00:00

abstract：:Smoking withdrawal is associated with significant deficits in the ability to initiate and maintain attention for extended periods of time (i.e. sustained attention; SA). However, the effects of smoking abstinence on the temporal dynamics of neurocognition during SA have not been evaluated. Twenty adult smokers underwe...

journal_title：Addiction biology

authors： Kozink RV,Lutz AM,Rose JE,Froeliger B,McClernon FJ

更新日期：2010-10-01 00:00:00

abstract：:Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction ...

journal_title：Addiction biology

authors： Barrós-Loscertales A,Costumero V,Rosell-Negre P,Fuentes-Claramonte P,Llopis-Llacer JJ,Bustamante JC

更新日期：2020-07-01 00:00:00

abstract：:Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...

journal_title：Addiction biology

authors： Espinosa-Carrasco J,Burokas A,Fructuoso M,Erb I,Martín-García E,Gutiérrez-Martos M,Notredame C,Maldonado R,Dierssen M

更新日期：2018-03-01 00:00:00

abstract：:The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...

journal_title：Addiction biology

authors： Zhang JT,Yao YW,Li CS,Zang YF,Shen ZJ,Liu L,Wang LJ,Liu B,Fang XY

更新日期：2016-05-01 00:00:00

abstract：:Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...

journal_title：Addiction biology

authors： Markou A,Li J,Tse K,Li X

更新日期：2018-01-01 00:00:00

abstract：:Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be involved in the pathophysiology of several disorders related to smoking and may be relevant for the pathophysiology of nico...

journal_title：Addiction biology

authors： Cohrs S,Rodenbeck A,Riemann D,Szagun B,Jaehne A,Brinkmeyer J,Gründer G,Wienker T,Diaz-Lacava A,Mobascher A,Dahmen N,Thuerauf N,Kornhuber J,Kiefer F,Gallinat J,Wagner M,Kunz D,Grittner U,Winterer G

更新日期：2014-05-01 00:00:00

abstract：:One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice. C57BL/6J mice were trained in operant conditioning maintain...

journal_title：Addiction biology

authors： Burokas A,Gutiérrez-Cuesta J,Martín-García E,Maldonado R

更新日期：2012-07-01 00:00:00

abstract：:Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...

journal_title：Addiction biology

authors： Rathitharan G,Truong J,Tong J,McCluskey T,Meyer JH,Mizrahi R,Warsh J,Rusjan P,Kennedy JL,Houle S,Kish SJ,Boileau I

更新日期：2021-01-01 00:00:00

abstract：:Substance use disorder is a complex disease created in part by maladaptive learning and memory mechanisms following repeated drug use. Exposure to drug-associated stimuli engages prefrontal cortex circuits, and dysfunction of the medial prefrontal cortex (mPFC) is thought to underlie drug-seeking behaviors. Growing ev...

journal_title：Addiction biology

authors： Jorgensen ET,Gonzalez AE,Harkness JH,Hegarty DM,Thakar A,Burchi DJ,Aadland JA,Aicher SA,Sorg BA,Brown TE

更新日期：2020-08-04 00:00:00

abstract：:We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a...

journal_title：Addiction biology

authors： Sommer C,Birkenstock J,Garbusow M,Obst E,Schad DJ,Bernhardt N,Huys QM,Wurst FM,Weinmann W,Heinz A,Smolka MN,Zimmermann US

更新日期：2020-01-01 00:00:00

abstract：:Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...

journal_title：Addiction biology

authors： Karimi-Haghighi S,Dargahi L,Haghparast A

更新日期：2020-03-01 00:00:00

abstract：:Combined anorectic-alcohol misuse is a prevalent problem in Brazil. In order to understand better the interactive effects of ethanol (EtOH) and mazindol (MZ), we examined the effects of EtOH (1.2 g/kg) and MZ (5.0 mg/kg) given alone or in combination, on mouse behaviour. The results indicate that EtOH plus MZ induces ...

journal_title：Addiction biology

authors： Gevaerd MS,Takahashi RN

更新日期：1996-01-01 00:00:00