The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals.

abstract：:Ethanol oxidation to acetaldehyde and next to acetate is accompanied by free radical generation. Free radicals can affect cell integrity when antioxidant mechanisms are no longer able to cope with the free radical generation observed in ethanol intoxication. Natural antioxidants are particularly useful in such a situa...

journal_title：Addiction biology

authors： Skrzydlewska E,Ostrowska J,Stankiewicz A,Farbiszewski R

更新日期：2002-07-01 00:00:00

abstract：:The total concentration of THC has been monitored in cannabis preparations sold in Dutch coffee shops since 1999. This annual monitoring was issued by the Ministry of Health after reports of increased potency. The level of the main psychoactive compound, Delta9-tetrahydrocannabinol (THC), is measured in marijuana and ...

journal_title：Addiction biology

authors： Pijlman FT,Rigter SM,Hoek J,Goldschmidt HM,Niesink RJ

更新日期：2005-06-01 00:00:00

abstract：:Selected ion flow tube mass spectrometry (SIFT-MS) has been used to measure simultaneously the concentrations of both carbon disulphide and acetone in exhaled breath following the ingestion of a single dose of disulfiram (Antabuse). Carbon disulphide is a product of the metabolism of disulfiram and is excreted mainly ...

journal_title：Addiction biology

authors： Bloor RN,Spanĕl P,Smith D

更新日期：2006-06-01 00:00:00

abstract：:Addiction is characterized by a persistent loss of behavioral control resulting in insensitivity to negative feedback and abnormal decision-making. Here, we investigated the influence of methamphetamine (METH)-paired contextual cues on decision-making in rats. Choice between goal-directed actions was sensitive to outc...

journal_title：Addiction biology

authors： Furlong TM,Supit AS,Corbit LH,Killcross S,Balleine BW

更新日期：2017-01-01 00:00:00

abstract：:Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...

journal_title：Addiction biology

authors： Vaquero L,Cámara E,Sampedro F,Pérez de Los Cobos J,Batlle F,Fabregas JM,Sales JA,Cervantes M,Ferrer X,Lazcano G,Rodríguez-Fornells A,Riba J

更新日期：2017-05-01 00:00:00

abstract：:Ethyl glucuronide (EtG) is a promising new biological state marker of recent alcohol consumption that detects alcohol use reliably over a definite time period. Other currently available markers lack acceptable sensitivity and specificity. Our aim is to elucidate under naturalistic conditions the time course of EtG exc...

journal_title：Addiction biology

authors： Wurst FM,Seidl S,Ladewig D,Müller-Spahn F,Alt A

更新日期：2002-10-01 00:00:00

abstract：:The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neur...

journal_title：Addiction biology

authors： Chu NN,Xia W,Yu P,Hu L,Zhang R,Cui CL

更新日期：2008-03-01 00:00:00

abstract：:α-Synuclein has recently been implicated in the pathophysiology of alcohol abuse due to its role in dopaminergic neurotransmission. In these studies, genetic variability in the α-synuclein gene influences its expression which may contribute to susceptibility to chronic alcohol abuse. Real-time PCR was used to quantify...

journal_title：Addiction biology

authors： Janeczek P,MacKay RK,Lea RA,Dodd PR,Lewohl JM

更新日期：2014-05-01 00:00:00

abstract：:The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim, male and female C57BL/6J mice (n = 60 per sex) were exposed to the drinking in the dark (DID) model for 4 weeks (DID-1 to DID-4). Dose-response effects of CBD on t...

journal_title：Addiction biology

authors： Viudez-Martínez A,García-Gutiérrez MS,Manzanares J

更新日期：2020-05-01 00:00:00

abstract：:Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2...

journal_title：Addiction biology

authors： Wang X,Liu Y,Jia M,Sun X,Wang N,Li Y,Cui C

更新日期：2018-09-01 00:00:00

abstract：:Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...

journal_title：Addiction biology

authors： Espinosa-Carrasco J,Burokas A,Fructuoso M,Erb I,Martín-García E,Gutiérrez-Martos M,Notredame C,Maldonado R,Dierssen M

更新日期：2018-03-01 00:00:00

abstract：:Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...

journal_title：Addiction biology

authors： Lidö HH,Marston H,Ericson M,Söderpalm B

更新日期：2012-09-01 00:00:00

abstract：:Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...

journal_title：Addiction biology

authors： Dunn KE,Weerts EM,Huhn AS,Schroeder JR,Tompkins DA,Bigelow GE,Strain EC

更新日期：2020-01-01 00:00:00

abstract：:Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the study of voluntary binge-like drinking (BD) in outbred Long-Evans rats by combining intermittent access to 20% ethanol in a two-bottle choice (IA2BC) paradigm t...

journal_title：Addiction biology

authors： Sauton P,Deschamps C,Jeanblanc V,Pierrefiche O,Jeanblanc J,Naassila M

更新日期：2020-12-16 00:00:00

abstract：:Alcohol exposure during fetal and early postnatal development can lead to an increased incidence of later life adult-onset diseases. Examples include central nervous system dysfunction, depression, anxiety, hyperactivity, and an inability to deal with stressful situations, increased infection and cancer. Direct effect...

journal_title：Addiction biology

authors： Sarkar DK

更新日期：2016-01-01 00:00:00

abstract：:Recent studies in animal models have shown that the nociceptin system, comprising nociceptin (or OFQ/N, encoded by PNOC) and the nociceptin receptor (an opioid receptor-like protein encoded by OPRL1), may be involved in alcohol and other drug reward pathways. To determine whether the nociceptin system is associated wi...

journal_title：Addiction biology

authors： Xuei X,Flury-Wetherill L,Almasy L,Bierut L,Tischfield J,Schuckit M,Nurnberger JI Jr,Foroud T,Edenberg HJ

更新日期：2008-03-01 00:00:00

abstract：:Identifying addicts with higher risk of relapse would provide the opportunity to implement individualized interventions and increase cessation success rates. Unfortunately, the ability to predict the long-term success of drug cessation treatments continues to elude researchers. We tested whether brain responses to emo...

journal_title：Addiction biology

authors： Versace F,Lam CY,Engelmann JM,Robinson JD,Minnix JA,Brown VL,Cinciripini PM

更新日期：2012-11-01 00:00:00

abstract：:Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result of altered gene expression in various brain regions. The present study investigated brain region-specific changes in the pattern and magnitude of gene expression immediately following chronic intermittent ethanol (CIE) exposure...

journal_title：Addiction biology

authors： Melendez RI,McGinty JF,Kalivas PW,Becker HC

更新日期：2012-03-01 00:00:00

abstract：:Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol dependence syndrome (ADS) in East Asian populations. Recently, attention has focused on the role of these SNPs in determining ADS risk in European populations. To ...

journal_title：Addiction biology

authors： Way M,McQuillin A,Saini J,Ruparelia K,Lydall GJ,Guerrini I,Ball D,Smith I,Quadri G,Thomson AD,Kasiakogia-Worlley K,Cherian R,Gunwardena P,Rao H,Kottalgi G,Patel S,Hillman A,Douglas E,Qureshi SY,Reynolds G,Jauhar S

更新日期：2015-05-01 00:00:00

abstract：:Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...

journal_title：Addiction biology

authors： Bellentani S,Saccoccio G,Masutti F,Giacca M,Miglioli L,Monzoni A,Tiribelli C

更新日期：2000-07-01 00:00:00

abstract：:Adolescence is characterized by considerable brain maturation that coincides with the development of adult behavior. Binge drinking is common during adolescence and can have deleterious effects on brain maturation because of the heightened neuroplasticity of the adolescent brain. Using an animal model of adolescent in...

journal_title：Addiction biology

authors： Vetreno RP,Yaxley R,Paniagua B,Crews FT

更新日期：2016-07-01 00:00:00

abstract：:The controversy over the relationship between heroin addiction and hepatocellular dysfunction was examined by assay of serum activities of aspartate and alanine aminotransferases, total protein, albumin and globulin in 48 chronic heroin smokers and 33 controls. Biliary secretion in the addicts was compared to controls...

journal_title：Addiction biology

authors： Banerjee D,Sarkar NK

更新日期：1996-01-01 00:00:00

abstract：:Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...

journal_title：Addiction biology

authors： Karimi-Haghighi S,Dargahi L,Haghparast A

更新日期：2020-03-01 00:00:00

abstract：:Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin....

journal_title：Addiction biology

authors： Stefanik MT,Moussawi K,Kupchik YM,Smith KC,Miller RL,Huff ML,Deisseroth K,Kalivas PW,LaLumiere RT

更新日期：2013-01-01 00:00:00

abstract：:Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...

journal_title：Addiction biology

authors： Palencia G,Calvillo M,Benita A,Sotelo J

更新日期：1998-10-01 00:00:00

abstract：:Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhe...

journal_title：Addiction biology

authors： Driscoll CA,Lindell SG,Schwandt ML,Suomi SJ,Higley JD,Heilig M,Barr CS

更新日期：2017-11-01 00:00:00

abstract：:The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...

journal_title：Addiction biology

authors： Adinoff B,Harris TS,Gu H,Stein EA

更新日期：2017-05-01 00:00:00

abstract：:Adolescent alcohol use is associated with increased risk for alcohol use disorders later in life; therefore, identifying biomarkers for initiation of heavy alcohol use, such as individual differences in the development of white-matter microstructure, may inform prevention strategies that improve public health. This pr...

journal_title：Addiction biology

authors： Morales AM,Jones SA,Harman G,Patching-Bunch J,Nagel BJ

更新日期：2020-05-01 00:00:00

abstract：:The neural and genetic factors underlying chronic tolerance to alcohol are currently unclear. The GluN2A N-methyl-D-aspartate receptors (NMDAR) subunit and the NMDAR-anchoring protein PSD-95 mediate acute alcohol intoxication and represent putative mechanisms mediating tolerance. We found that chronic intermittent eth...

journal_title：Addiction biology

authors： Daut RA,Busch EF,Ihne J,Fisher D,Mishina M,Grant SG,Camp M,Holmes A

更新日期：2015-03-01 00:00:00

abstract：:Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present ...

journal_title：Addiction biology

authors： Dijkstra BA,De Jong CA,Bluschke SM,Krabbe PF,van der Staak CP

更新日期：2007-06-01 00:00:00