Time-course and dynamics of obesity-related behavioral changes induced by energy-dense foods in mice.

abstract：:Ethanol oxidation to acetaldehyde and next to acetate is accompanied by free radical generation. Free radicals can affect cell integrity when antioxidant mechanisms are no longer able to cope with the free radical generation observed in ethanol intoxication. Natural antioxidants are particularly useful in such a situa...

journal_title：Addiction biology

authors： Skrzydlewska E,Ostrowska J,Stankiewicz A,Farbiszewski R

更新日期：2002-07-01 00:00:00

abstract：:Several studies have emphasized the role of learning in the development of rapid and chronic tolerances. Recently, it was shown that the NMDA antagonists MK-801(dizocilpine) and ketamine block the development of tolerance to ethanol in rats submitted to tilt-plane apparatus. The present study examines the generality o...

journal_title：Addiction biology

authors： Barreto PS,Lemos T,Morato GS

更新日期：1998-01-01 00:00:00

abstract：:Betel quid chewing has been claimed to produce a sense of well-being, euphoria, warm sensation of the body, sweating, salivation, palpitation, heightened alertness and increased capacity to work. These effects suggest that betel quid chewing affects predominantly the central and autonomic nervous systems. Several stud...

journal_title：Addiction biology

authors： Chu NS

更新日期：2002-01-01 00:00:00

abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...

journal_title：Addiction biology

authors： Tam PG

更新日期：2017-01-01 00:00:00

abstract：:Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...

journal_title：Addiction biology

authors： Kim M,Custodio RJ,Botanas CJ,de la Peña JB,Sayson LV,Abiero A,Ryoo ZY,Cheong JH,Kim HJ

更新日期：2019-09-01 00:00:00

abstract：:Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...

journal_title：Addiction biology

authors： Pavon FJ,Serrano A,Sidhpura N,Polis I,Stouffer D,de Fonseca FR,Cravatt BF,Martin-Fardon R,Parsons LH

更新日期：2018-03-01 00:00:00

abstract：:Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...

journal_title：Addiction biology

authors： Tabernero MJ,Bermejo AM,Fernandez P

更新日期：1999-10-01 00:00:00

abstract：:Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inabilit...

journal_title：Addiction biology

authors： Hagerty SL,YorkWilliams SL,Bidwell LC,Weiland BJ,Sabbineni A,Blaine SK,Bryan AD,Hutchison KE

更新日期：2020-01-01 00:00:00

abstract：:Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...

journal_title：Addiction biology

authors： Mori T,Rahmadi M,Yoshizawa K,Itoh T,Shibasaki M,Suzuki T

更新日期：2014-05-01 00:00:00

abstract：:The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...

journal_title：Addiction biology

authors： Gamaleddin I,Wertheim C,Zhu AZ,Coen KM,Vemuri K,Makryannis A,Goldberg SR,Le Foll B

更新日期：2012-01-01 00:00:00

abstract：:The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...

journal_title：Addiction biology

authors： Wolff CB,Peters TJ,Keating J,Gardner WN

更新日期：1999-04-01 00:00:00

abstract：:Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the study of voluntary binge-like drinking (BD) in outbred Long-Evans rats by combining intermittent access to 20% ethanol in a two-bottle choice (IA2BC) paradigm t...

journal_title：Addiction biology

authors： Sauton P,Deschamps C,Jeanblanc V,Pierrefiche O,Jeanblanc J,Naassila M

更新日期：2020-12-16 00:00:00

abstract：:Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in the treatment of drug dependence and drug withdrawal. Oxytocin reduces methamphetamine self-administration, conditioned place preference and hyperactivity in rodents. However, it is unclear how oxytocin acts in the brain to prod...

journal_title：Addiction biology

authors： Carson DS,Hunt GE,Guastella AJ,Barber L,Cornish JL,Arnold JC,Boucher AA,McGregor IS

更新日期：2010-10-01 00:00:00

abstract：:In keeping with its ability to control the mesoaccumbens dopamine (DA) pathway, the serotonin2C receptor (5-HT2C R) plays a key role in mediating the behavioral and neurochemical effects of drugs of abuse. Studies assessing the influence of 5-HT2C R agonists on cocaine-induced responses have suggested that 5-HT2C Rs c...

journal_title：Addiction biology

authors： Cathala A,Devroye C,Maitre M,Piazza PV,Abrous DN,Revest JM,Spampinato U

更新日期：2015-05-01 00:00:00

abstract：:Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or preven...

journal_title：Addiction biology

authors： Simon-O'Brien E,Alaux-Cantin S,Warnault V,Buttolo R,Naassila M,Vilpoux C

更新日期：2015-07-01 00:00:00

abstract：:It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subje...

journal_title：Addiction biology

authors： Loeber S,Vollstädt-Klein S,von der Goltz C,Flor H,Mann K,Kiefer F

更新日期：2009-04-01 00:00:00

abstract：:The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are more likely to use alcohol to cope w...

journal_title：Addiction biology

authors： Bilbao A,Leixner S,Wei S,Cantacorps L,Valverde O,Spanagel R

更新日期：2019-09-01 00:00:00

abstract：:Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...

journal_title：Addiction biology

authors： Lydon-Staley DM,MacLean RR,Falk EB,Bassett DS,Wilson SJ

更新日期：2021-01-28 00:00:00

abstract：:Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...

journal_title：Addiction biology

authors： Lidö HH,Marston H,Ericson M,Söderpalm B

更新日期：2012-09-01 00:00:00

abstract：:The genetic and environmental contributions to differences in response to ethanol have been examined widely using inbred strains, selected lines and genetically engineered (transgenic and 'knock-out') animals. In addition, recombinant inbred strains have been used to identify QTLs (chromosomal regions) associated with...

journal_title：Addiction biology

authors： Hoffman P,Tabakoff B

更新日期：2005-03-01 00:00:00

abstract：:Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of ...

journal_title：Addiction biology

authors： Gamaleya N,Tronnikov S,Ulyanova L,Klimova S,Dmitrieva I

更新日期：1996-01-01 00:00:00

abstract：:Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...

journal_title：Addiction biology

authors： Gerra G,Garofano L,Pellegrini C,Bosari S,Zaimovic A,Moi G,Avanzini P,Talarico E,Gardini F,Donnini C

更新日期：2005-09-01 00:00:00

abstract：:Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the bra...

journal_title：Addiction biology

authors： Chen J,Liu Q,Fan R,Han H,Yang Z,Cui W,Song G,Li MD

更新日期：2020-01-01 00:00:00

abstract：:Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing m...

journal_title：Addiction biology

authors： Lao-Peregrín C,Ballesteros JJ,Fernández M,Zamora-Moratalla A,Saavedra A,Gómez Lázaro M,Pérez-Navarro E,Burks D,Martín ED

更新日期：2017-11-01 00:00:00

abstract：:Chronic and excessive alcohol consumption induces defined myocardial lesions characterized by impaired structural, mechanical and biochemical features. The pathogenic mechanisms are unknown, although it is possible that protein adduct formation by reactive metabolites of ethanol may be a contributory process. Hitherto...

journal_title：Addiction biology

authors： Worrall S,Richardson PJ,Preedy VR

更新日期：2000-10-01 00:00:00

abstract：:The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...

journal_title：Addiction biology

authors： Wang YJ,Huang P,Blendy JA,Liu-Chen LY

更新日期：2014-05-01 00:00:00

abstract：:Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...

journal_title：Addiction biology

authors： Hwa LS,Shimamoto A,Kayyali T,Norman KJ,Valentino RJ,DeBold JF,Miczek KA

更新日期：2016-01-01 00:00:00

abstract：:The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...

journal_title：Addiction biology

authors： McLachlan-Troup N,Taylor GW,Trathen BC

更新日期：2001-07-01 00:00:00

abstract：:Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...

journal_title：Addiction biology

authors： Teichtahl H,Wang D,Cunnington D,Kronborg I,Goodman C,Prodromidis A,Drummer O

更新日期：2004-09-01 00:00:00

abstract：:Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and the cystine-glutamate exchange protein xCT within the nucleus accumbens core (NAcore). N-acetylcysteine (NAC) has been shown to restore these proteins in a rodent model of drug addiction and relapse. How...

journal_title：Addiction biology

authors： Namba MD,Kupchik YM,Spencer SM,Garcia-Keller C,Goenaga JG,Powell GL,Vicino IA,Hogue IB,Gipson CD

更新日期：2020-09-01 00:00:00