NMDA-receptor antagonists block the development of rapid tolerance to ethanol in mice.

abstract：:The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are more likely to use alcohol to cope w...

journal_title：Addiction biology

authors： Bilbao A,Leixner S,Wei S,Cantacorps L,Valverde O,Spanagel R

更新日期：2019-09-01 00:00:00

abstract：:Impulsive delayed reward discounting (DRD) is an important behavioral process in alcohol use disorders (AUDs), reflecting incapacity to delay gratification. Recent work in neuroeconomics has begun to unravel the neural mechanisms supporting DRD, but applications of neuroeconomics in relation to AUDs have been limited....

journal_title：Addiction biology

authors： Amlung M,Sweet LH,Acker J,Brown CL,MacKillop J

更新日期：2014-07-01 00:00:00

abstract：:Alcoholic drinks are capable of triggering a wide range of allergic and allergic-like responses, including rhinitis, itching, facial swelling, headache, cough and asthma. Limited epidemiological data suggests that many individuals are affected and that sensitivities occur to a variety of drinks, including wine, beer a...

journal_title：Addiction biology

authors： Vally H,Thompson PJ

更新日期：2003-03-01 00:00:00

abstract：:Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cogn...

journal_title：Addiction biology

authors： González B,Bernardi A,Torres OV,Jayanthi S,Gomez N,Sosa MH,García-Rill E,Urbano FJ,Cadet JL,Bisagno V

更新日期：2020-03-01 00:00:00

abstract：:Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...

journal_title：Addiction biology

authors： Teichtahl H,Wang D,Cunnington D,Kronborg I,Goodman C,Prodromidis A,Drummer O

更新日期：2004-09-01 00:00:00

abstract：:Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...

journal_title：Addiction biology

authors： Schote AB,Jäger K,Kroll SL,Vonmoos M,Hulka LM,Preller KH,Meyer J,Grünblatt E,Quednow BB

更新日期：2019-07-01 00:00:00

abstract：:Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CU...

journal_title：Addiction biology

authors： Hindocha C,Freeman TP,Schafer G,Gardner C,Bloomfield MAP,Bramon E,Morgan CJA,Curran HV

更新日期：2020-05-01 00:00:00

abstract：:Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...

journal_title：Addiction biology

authors： Vaquero L,Cámara E,Sampedro F,Pérez de Los Cobos J,Batlle F,Fabregas JM,Sales JA,Cervantes M,Ferrer X,Lazcano G,Rodríguez-Fornells A,Riba J

更新日期：2017-05-01 00:00:00

abstract：:The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The...

journal_title：Addiction biology

authors： Vinod KY,Maccioni P,Garcia-Gutierrez MS,Femenia T,Xie S,Carai MA,Manzanares J,Cooper TB,Hungund BL,Colombo G

更新日期：2012-01-01 00:00:00

abstract：:The total concentration of THC has been monitored in cannabis preparations sold in Dutch coffee shops since 1999. This annual monitoring was issued by the Ministry of Health after reports of increased potency. The level of the main psychoactive compound, Delta9-tetrahydrocannabinol (THC), is measured in marijuana and ...

journal_title：Addiction biology

authors： Pijlman FT,Rigter SM,Hoek J,Goldschmidt HM,Niesink RJ

更新日期：2005-06-01 00:00:00

abstract：:Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result of altered gene expression in various brain regions. The present study investigated brain region-specific changes in the pattern and magnitude of gene expression immediately following chronic intermittent ethanol (CIE) exposure...

journal_title：Addiction biology

authors： Melendez RI,McGinty JF,Kalivas PW,Becker HC

更新日期：2012-03-01 00:00:00

abstract：:Phosphatidylethanol (PEth), a direct ethanol metabolite, is detectable in blood for more than 2 weeks after sustained ethanol intake. Our aim was to assess the usefulness of PEth [comparing sensitivity, specificity and the area under the curve (AUC)] as compared with carbohydrate-deficient transferrin (CDT), gamma-glu...

journal_title：Addiction biology

authors： Hartmann S,Aradottir S,Graf M,Wiesbeck G,Lesch O,Ramskogler K,Wolfersdorf M,Alling C,Wurst FM

更新日期：2007-03-01 00:00:00

abstract：:Previous work suggests a role for dopamine D3-like receptors in psychostimulant reinforcement. The development of new compounds acting selectively at dopamine D3 receptors has opened new possibilities to explore the role of these receptors in animal models of psychostimulant dependence. Here we investigated whether th...

journal_title：Addiction biology

authors： Orio L,Wee S,Newman AH,Pulvirenti L,Koob GF

更新日期：2010-07-01 00:00:00

abstract：:Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2...

journal_title：Addiction biology

authors： Wang X,Liu Y,Jia M,Sun X,Wang N,Li Y,Cui C

更新日期：2018-09-01 00:00:00

abstract：:Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...

journal_title：Addiction biology

authors： Martín-García E,Fernández-Castillo N,Burokas A,Gutiérrez-Cuesta J,Sánchez-Mora C,Casas M,Ribasés M,Cormand B,Maldonado R

更新日期：2015-01-01 00:00:00

abstract：:Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...

journal_title：Addiction biology

authors： Loftén A,Adermark L,Ericson M,Söderpalm B

更新日期：2020-08-13 00:00:00

abstract：:Previous studies on acetaldehyde dehydrogenase 2 (ALDH2) focused on drinking behavior or alcoholism because the ALDH2*2 allele protects against the risk of developing alcoholism. The mechanism provides that the ALDH2 gene's protective effect is also involved in dopamine metabolism. The interaction of the ALDH2 gene wi...

journal_title：Addiction biology

authors： Lu RB,Lee JF,Huang SY,Lee SY,Chang YH,Kuo PH,Chen SL,Chen SH,Chu CH,Lin WW,Wu PL,Ko HC

更新日期：2012-09-01 00:00:00

abstract：:Chemical compounds that target dopamine (DA) D1 or D3 receptors have shown promise as potential interventions in animal models of cue-induced relapse. However, undesirable side effects or pharmacodynamic profiles have limited the advancement of new compounds in preclinical studies when administered as independent trea...

journal_title：Addiction biology

authors： Ewing ST,Dorcely C,Maidi R,Paker G,Schelbaum E,Ranaldi R

更新日期：2021-01-25 00:00:00

abstract：:Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspe...

journal_title：Addiction biology

authors： McKee SA

更新日期：2009-01-01 00:00:00

abstract：:Smoking withdrawal is associated with significant deficits in the ability to initiate and maintain attention for extended periods of time (i.e. sustained attention; SA). However, the effects of smoking abstinence on the temporal dynamics of neurocognition during SA have not been evaluated. Twenty adult smokers underwe...

journal_title：Addiction biology

authors： Kozink RV,Lutz AM,Rose JE,Froeliger B,McClernon FJ

更新日期：2010-10-01 00:00:00

abstract：:It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subje...

journal_title：Addiction biology

authors： Loeber S,Vollstädt-Klein S,von der Goltz C,Flor H,Mann K,Kiefer F

更新日期：2009-04-01 00:00:00

abstract：:Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of comp...

journal_title：Addiction biology

authors： Brick LA,Keller MC,Knopik VS,McGeary JE,Palmer RHC

更新日期：2019-01-01 00:00:00

abstract：:Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their influence on cocaine-dependent behavioral and neuronal plasticity has not been explained. In this s...

journal_title：Addiction biology

authors： Mongi-Bragato B,Zamponi E,García-Keller C,Assis MA,Virgolini MB,Mascó DH,Zimmer A,Cancela LM

更新日期：2016-03-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...

journal_title：Addiction biology

authors： Navarrete F,Rubio G,Manzanares J

更新日期：2014-09-01 00:00:00

abstract：:Based on the knowledge that alcohol misuse causes a multitude of diseases and increased mortality, this systematic review examines whether a reduction of the individual alcohol consumption can contribute to a minimization of health risks within a harm reduction approach. In fact, the reviewed 63 studies indicate that ...

journal_title：Addiction biology

authors： Charlet K,Heinz A

更新日期：2017-09-01 00:00:00

abstract：:Erythroycte delta aminolevulinic acid dehydratase (ALAD) has been suggested as a marker for detecting recent alcohol intake. Unlike other markers, ALAD activity decreases after alcohol intake. Review of the literature suggests that the main interest in this marker is because it increases rapidly after withdrawal. The ...

journal_title：Addiction biology

authors： Aubin HJ,Laureaux C,Tilikete S,Gillet C,Lepetitcorps A,Nguyen T,Troupel S,Paille F,Barrucand D

更新日期：1997-04-01 00:00:00

abstract：:Transferrin (T f) and its carbohydrate-deficient isoform (CDT) were measured by radioimmunoassay in phosphate-buffered saline extracts of two informative areas of cerebral cortex tissue obtained at autopsy from alcoholics without other associated disease (n = 4); alcoholics with cirrhosis of the liver (n = 4) and agem...

journal_title：Addiction biology

authors： Dodd PR,Eckert AL,Fletcher LM,Kril JJ,Harper CG,Halliday JW

更新日期：1997-07-01 00:00:00

abstract：:Major advances have been made in understanding nicotine addiction and smoking behaviour in recent years. In particular, evidence for the relative importance of genetic and environmental effects on smoking initiation and persistence has emerged from behaviour genetic studies. These data have supported evidence from mol...

journal_title：Addiction biology

authors： Munafò M,Johnstone E,Murphy M,Walton R

更新日期：2001-04-01 00:00:00

abstract：:Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...

journal_title：Addiction biology

authors： Dunn KE,Weerts EM,Huhn AS,Schroeder JR,Tompkins DA,Bigelow GE,Strain EC

更新日期：2020-01-01 00:00:00

abstract：:Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...

journal_title：Addiction biology

authors： Rathitharan G,Truong J,Tong J,McCluskey T,Meyer JH,Mizrahi R,Warsh J,Rusjan P,Kennedy JL,Houle S,Kish SJ,Boileau I

更新日期：2021-01-01 00:00:00