Abstract：
:Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspects of smoking behavior and nicotine dependence phenomena, none have yet modeled smoking lapse behavior. The first instance of smoking during a quit attempt (i.e. smoking lapse) is highly predictive of relapse and represents an important target for medications development. Focusing on an abstinence outcome is critical for medication screening as the US Food and Drug Administration approval for cessation medications is contingent on demonstrating effects on smoking abstinence. This paper outlines a three-stage process for the development of a smoking lapse model for the purpose of medication screening. The smoking lapse paradigm models two critical features of lapse behavior: the ability to resist the first cigarette and subsequent ad libitum smoking. Within the context of the model, smokers are first exposed to known precipitants of smoking relapse (e.g. nicotine deprivation, alcohol, stress), and then presented their preferred brand of cigarettes. Their ability to resist smoking is then modeled and once smokers 'give in' and decide to smoke, they participate in a tobacco self-administration session. Ongoing and completed work developing and validating these models for the purpose of medication screening is discussed.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
McKee SAdoi
10.1111/j.1369-1600.2008.00135.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
99-107issue
1eissn
1355-6215issn
1369-1600pii
ADB135journal_volume
14pub_type
杂志文章,评审abstract：:Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inabilit...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12684
更新日期：2020-01-01 00:00:00
abstract：:Copy number variations (CNVs) can alter the DNA sequence in blocks ranging from kilobases to megabases, involving more total nucleotides than single nucleotide polymorphisms. Yet, its impact in humans is far from fully understood. In this study, we investigate the relationship of genome-wide CNVs with brain function e...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00393.x
更新日期：2013-05-01 00:00:00
abstract：:Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investig...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12912
更新日期：2020-04-23 00:00:00
abstract：:This review article discusses the importance of identifying gene-environment interactions for understanding the etiology and course of alcohol use disorders and related conditions. A number of critical challenges are discussed, including the fact that there is no organizing typology for classifying different types of ...
journal_title：Addiction biology
pub_type： 杂志文章,评审
doi：10.1111/j.1369-1600.2009.00189.x
更新日期：2010-04-01 00:00:00
abstract：:Addiction is characterized by a persistent loss of behavioral control resulting in insensitivity to negative feedback and abnormal decision-making. Here, we investigated the influence of methamphetamine (METH)-paired contextual cues on decision-making in rats. Choice between goal-directed actions was sensitive to outc...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12316
更新日期：2017-01-01 00:00:00
abstract：:Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing m...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12433
更新日期：2017-11-01 00:00:00
abstract：:Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combine...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12492
更新日期：2018-01-01 00:00:00
abstract：:Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic opioid administration are thought to contribute to the pathogenesis and persistence of opiate addiction. In order to identify candidate genes involved in these neuroadaptations, we utilized a behavior-genetics strategy designed ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2012.00470.x
更新日期：2013-05-01 00:00:00
abstract：:Despite the fact that several data have supported the involvement of the cerebellum in the functional alterations observed after prolonged cocaine use, this brain structure has been traditionally ignored and excluded from the circuitry affected by addictive drugs. In the present study, we investigated the effects of a...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12223
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or hi...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12702
更新日期：2020-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12746
更新日期：2020-05-01 00:00:00
abstract：:Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational u...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12038
更新日期：2013-09-01 00:00:00
abstract：:While the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. The focus of the present study is to determine whether genetic variation in the tryptophan hyd...
journal_title：Addiction biology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1369-1600.2006.00005.x
更新日期：2006-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00341.x
更新日期：2011-10-01 00:00:00
abstract：:Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.13001
更新日期：2021-01-28 00:00:00
abstract：:Substance use disorder is a complex disease created in part by maladaptive learning and memory mechanisms following repeated drug use. Exposure to drug-associated stimuli engages prefrontal cortex circuits, and dysfunction of the medial prefrontal cortex (mPFC) is thought to underlie drug-seeking behaviors. Growing ev...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12947
更新日期：2020-08-04 00:00:00
abstract：:Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12595
更新日期：2018-03-01 00:00:00
abstract：:Nicotine withdrawal is associated with subtle working memory deficits that predict subsequent relapse. We examined the neural substrates underlying these processes in treatment-seeking smokers, and explored the moderating influence of age on abstinence-induced alterations in brain activity and performance. Sixty-three...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12051
更新日期：2014-09-01 00:00:00
abstract：:The capacity of the liver to synthesize insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) may be compromised by alcohol. The characteristics of IGFBP-3 variants obtained from healthy individuals and patients with alcoholic cirrhosis (ALC) were compared. Concanavalin A (Con A) affinity electrophore...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/1355621031000069927
更新日期：2003-03-01 00:00:00
abstract：:Although adolescents are a group heavily targeted by the e-cigarette industry, research in cue-reactivity has not previously examined adolescents' behavioral and neural responses to e-cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12510
更新日期：2018-03-01 00:00:00
abstract：:The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...
journal_title：Addiction biology
pub_type： 杂志文章,随机对照试验
doi：10.1111/adb.12611
更新日期：2019-05-01 00:00:00
abstract：:We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12294
更新日期：2017-01-01 00:00:00
abstract：:This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated. The two-bottle choice par...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12495
更新日期：2018-01-01 00:00:00
abstract：:Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12531
更新日期：2018-03-01 00:00:00
abstract：:Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12688
更新日期：2019-11-01 00:00:00
abstract：:Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00367.x
更新日期：2012-09-01 00:00:00
abstract：:Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12706
更新日期：2020-03-01 00:00:00
abstract：:Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be involved in the pathophysiology of several disorders related to smoking and may be relevant for the pathophysiology of nico...
journal_title：Addiction biology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1369-1600.2012.00487.x
更新日期：2014-05-01 00:00:00
abstract：:Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impair...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12584
更新日期：2019-03-01 00:00:00
abstract：:The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12946
更新日期：2020-08-14 00:00:00
