Brain GABA levels are reduced in alcoholic liver disease: A proton magnetic resonance spectroscopy study.


BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or history of heavy drinking. The aim of this paper was to examine the association of cortical GABA+ concentration with severity of liver disease (including markers of liver injury) and other clinical characteristics in alcohol patients. METHODS:Proton magnetic resonance spectroscopy (1 H-MRS), from the parietal lobe, was analyzed to yield absolute concentration of GABA in 24 alcohol-dependent individuals. Diagnosis of ALD, markers of liver injury, severity of liver disease (Model for End-Stage Liver Disease [MELD]), and alcohol history were assessed. Covariates included concurrent medication, age, and recent alcohol consumption. RESULTS:Multiple linear regression revealed that GABA+ concentration was significantly predicted by MELD scores (F = 5.02, R2  = 0.59, P = 0.01; MELD: B = -0.63, P = 0.02), when controlling for covariates concurrent medication, age, and recent alcohol consumption. CONCLUSION:Severity of ALD is associated with lower cortical concentrations of GABA+. These results may explain variations in response to the GABAB agonist, baclofen, in the alcohol-dependent population.


Addict Biol


Addiction biology


Morley KC,Lagopoulos J,Logge W,Baillie A,Adams C,Haber PS




Has Abstract


2020-01-01 00:00:00












  • Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin.

    abstract::The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...

    journal_title:Addiction biology

    pub_type: 杂志文章,随机对照试验


    authors: Zhang X,Nielsen DA,Domingo CB,Shorter DI,Nielsen EM,Kosten TR

    更新日期:2019-05-01 00:00:00

  • Ethyl glucuronide: on the time course of excretion in urine during detoxification.

    abstract::Ethyl glucuronide (EtG) is a promising new biological state marker of recent alcohol consumption that detects alcohol use reliably over a definite time period. Other currently available markers lack acceptable sensitivity and specificity. Our aim is to elucidate under naturalistic conditions the time course of EtG exc...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Wurst FM,Seidl S,Ladewig D,Müller-Spahn F,Alt A

    更新日期:2002-10-01 00:00:00

  • Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization.

    abstract::Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their influence on cocaine-dependent behavioral and neuronal plasticity has not been explained. In this s...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Mongi-Bragato B,Zamponi E,García-Keller C,Assis MA,Virgolini MB,Mascó DH,Zimmer A,Cancela LM

    更新日期:2016-03-01 00:00:00

  • Nicotine increases sucrose self-administration and seeking in rats.

    abstract::Associations between nicotine in cigarettes and food consumption may alter the incentive value of food such that food cue-reactivity is exaggerated during abstinence from smoking. This effect may contribute to the weight gain associated with cessation of smoking. We examined the effects of nicotine (0.4 mg/kg base sub...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Grimm JW,Ratliff C,North K,Barnes J,Collins S

    更新日期:2012-05-01 00:00:00

  • White matter connectivity and Internet gaming disorder.

    abstract::Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subj...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Jeong BS,Han DH,Kim SM,Lee SW,Renshaw PF

    更新日期:2016-05-01 00:00:00

  • Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats.

    abstract::Cocaine self-administration in rats results in dysfunctional neuroadaptations in the prelimbic (PrL) cortex during early abstinence. Central to these adaptations is decreased phospho-extracellular signal-regulated kinase (p-ERK), which plays a key role in cocaine seeking. Normalizing ERK phosphorylation in the PrL cor...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Siemsen BM,Lombroso PJ,McGinty JF

    更新日期:2018-01-01 00:00:00

  • Noradrenergic signaling in the VTA modulates cocaine craving.

    abstract::Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Solecki WB,Szklarczyk K,Pradel K,Kwiatkowska K,Dobrzański G,Przewłocki R

    更新日期:2018-03-01 00:00:00

  • Does naltrexone affect craving in abstinent opioid-dependent patients?

    abstract::Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present ...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Dijkstra BA,De Jong CA,Bluschke SM,Krabbe PF,van der Staak CP

    更新日期:2007-06-01 00:00:00

  • Developing human laboratory models of smoking lapse behavior for medication screening.

    abstract::Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspe...

    journal_title:Addiction biology

    pub_type: 杂志文章,评审


    authors: McKee SA

    更新日期:2009-01-01 00:00:00

  • Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior.

    abstract::Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and the cystine-glutamate exchange protein xCT within the nucleus accumbens core (NAcore). N-acetylcysteine (NAC) has been shown to restore these proteins in a rodent model of drug addiction and relapse. How...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Namba MD,Kupchik YM,Spencer SM,Garcia-Keller C,Goenaga JG,Powell GL,Vicino IA,Hogue IB,Gipson CD

    更新日期:2020-09-01 00:00:00

  • The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens.

    abstract::Methamphetamine (METH) markedly increases dopamine (DA) release in the mesolimbic DA system, which plays an important role in mediating the reinforcing effects of METH. METH-induced DA release results in the formation of reactive oxygen species (ROS), leading to oxidative damage. We have recently reported that ROS are...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Jang EY,Yang CH,Hedges DM,Kim SP,Lee JY,Ekins TG,Garcia BT,Kim HY,Nelson AC,Kim NJ,Steffensen SC

    更新日期:2017-09-01 00:00:00

  • Involving the cerebellum in cocaine-induced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine.

    abstract::Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Carbo-Gas M,Vazquez-Sanroman D,Aguirre-Manzo L,Coria-Avila GA,Manzo J,Sanchis-Segura C,Miquel M

    更新日期:2014-01-01 00:00:00

  • Dissociable brain signatures of choice conflict and immediate reward preferences in alcohol use disorders.

    abstract::Impulsive delayed reward discounting (DRD) is an important behavioral process in alcohol use disorders (AUDs), reflecting incapacity to delay gratification. Recent work in neuroeconomics has begun to unravel the neural mechanisms supporting DRD, but applications of neuroeconomics in relation to AUDs have been limited....

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Amlung M,Sweet LH,Acker J,Brown CL,MacKillop J

    更新日期:2014-07-01 00:00:00

  • Inflated reward value in early opiate withdrawal.

    abstract::Through incentive learning, the emotional experience of a reward in a relevant need state (e.g. hunger for food) sets the incentive value that guides the performance of actions that earn that reward when the need state is encountered again. Opiate withdrawal has been proposed as a need state in which, through experien...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Wassum KM,Greenfield VY,Linker KE,Maidment NT,Ostlund SB

    更新日期:2016-03-01 00:00:00

  • Apoptosis induction by phencyclidine in the brains of rats of different ages.

    abstract::We examined whether acute administration of phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate (NMDA) receptor-channel complex, can cause neuronal toxicity that is associated with apoptosis. Three- and 24-month-old rats were placed in locomotor activity chambers. PCP (50 mg/kg) or saline (0.15 M NaCl) were...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Milosević J,Veskov R,Vasilev V,Rakić L,Ruzdijić S

    更新日期:2000-04-01 00:00:00

  • Time-course and dynamics of obesity-related behavioral changes induced by energy-dense foods in mice.

    abstract::Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Espinosa-Carrasco J,Burokas A,Fructuoso M,Erb I,Martín-García E,Gutiérrez-Martos M,Notredame C,Maldonado R,Dierssen M

    更新日期:2018-03-01 00:00:00

  • Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain.

    abstract::The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are more likely to use alcohol to cope w...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Bilbao A,Leixner S,Wei S,Cantacorps L,Valverde O,Spanagel R

    更新日期:2019-09-01 00:00:00

  • How useful is aminolevulinic acid dehydratase as a marker of recent alcohol intake?

    abstract::Erythroycte delta aminolevulinic acid dehydratase (ALAD) has been suggested as a marker for detecting recent alcohol intake. Unlike other markers, ALAD activity decreases after alcohol intake. Review of the literature suggests that the main interest in this marker is because it increases rapidly after withdrawal. The ...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Aubin HJ,Laureaux C,Tilikete S,Gillet C,Lepetitcorps A,Nguyen T,Troupel S,Paille F,Barrucand D

    更新日期:1997-04-01 00:00:00

  • Effect of methamphetamine dependence on heart rate variability.

    abstract::Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Henry BL,Minassian A,Perry W

    更新日期:2012-05-01 00:00:00

  • The feasibility of an in-scanner smoking lapse paradigm to examine the neural correlates of lapses.

    abstract::Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Lydon-Staley DM,MacLean RR,Falk EB,Bassett DS,Wilson SJ

    更新日期:2021-01-28 00:00:00

  • Interstrain differences in voluntary binge-like drinking behavior and in two acute ethanol injections-induced synaptic plasticity deficits in rats.

    abstract::Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the study of voluntary binge-like drinking (BD) in outbred Long-Evans rats by combining intermittent access to 20% ethanol in a two-bottle choice (IA2BC) paradigm t...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Sauton P,Deschamps C,Jeanblanc V,Pierrefiche O,Jeanblanc J,Naassila M

    更新日期:2020-12-16 00:00:00

  • The pharmacology of psilocybin.

    abstract::Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide. These mushrooms represent a growing problem regarding hallucinogenic drug abuse. Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocy...

    journal_title:Addiction biology

    pub_type: 杂志文章,评审


    authors: Passie T,Seifert J,Schneider U,Emrich HM

    更新日期:2002-10-01 00:00:00

  • New directions in the genetic mechanisms underlying nicotine addiction.

    abstract::Major advances have been made in understanding nicotine addiction and smoking behaviour in recent years. In particular, evidence for the relative importance of genetic and environmental effects on smoking initiation and persistence has emerged from behaviour genetic studies. These data have supported evidence from mol...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Munafò M,Johnstone E,Murphy M,Walton R

    更新日期:2001-04-01 00:00:00

  • Chronic ethanol intake and ageing effects on cortical and basal forebrain cholinergic parameters: morphometric and biochemical studies.

    abstract::Abstract Twenty-eight Wistar rats treated orally with 20% ethanol solution, were divided into two groups: adult group (n = 19) and aged group (n = 9) consisting of animals aged 4 and 12 months, respectively, at the beginning of the treatment. Neurons from the basal nucleus region were counted and the percentage of cho...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Fernandes PA,Ribeiro AM,Pereira RF,Marra HL,Pittella JE

    更新日期:2002-01-01 00:00:00

  • Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking.

    abstract::The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Gamaleddin I,Wertheim C,Zhu AZ,Coen KM,Vemuri K,Makryannis A,Goldberg SR,Le Foll B

    更新日期:2012-01-01 00:00:00

  • Frustrated expected reward induces differential transcriptional changes in the mouse brain.

    abstract::Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Martín-García E,Fernández-Castillo N,Burokas A,Gutiérrez-Cuesta J,Sánchez-Mora C,Casas M,Ribasés M,Cormand B,Maldonado R

    更新日期:2015-01-01 00:00:00

  • Cannabidiol reduces ethanol consumption, motivation and relapse in mice.

    abstract::This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated. The two-bottle choice par...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Viudez-Martínez A,García-Gutiérrez MS,Navarrón CM,Morales-Calero MI,Navarrete F,Torres-Suárez AI,Manzanares J

    更新日期:2018-01-01 00:00:00

  • Molecular basis of reduced birth weight in smoking pregnant women: mitochondrial dysfunction and apoptosis.

    abstract::In utero exposure of fetuses to tobacco is associated with reduced birth weight. We hypothesized that this may be due to the toxic effect of carbon monoxide (CO) from tobacco, which has previously been described to damage mitochondria in non-pregnant adult smokers. Maternal peripheral blood mononuclear cells (PBMCs), ...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Garrabou G,Hernàndez AS,Catalán García M,Morén C,Tobías E,Córdoba S,López M,Figueras F,Grau JM,Cardellach F

    更新日期:2016-01-01 00:00:00

  • Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization.

    abstract::The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that controls global protein synthesis, in part, by modulating translation initiation, a rate-limiting step for many mRNAs. Previous studies implicate mTOR in regulating stimulant-induced sensitization and antidepressive-like behavior in rodents, as...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Bailey J,Ma D,Szumlinski KK

    更新日期:2012-03-01 00:00:00

  • Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens.

    abstract::Several genetic polymorphisms have been reported to be associated with alcohol withdrawal seizures (AWS) and delirium tremens (DT). To replicate and further explore these findings, we investigated the effects of 12 previously reported candidate genetic variations in two groups of alcohol-dependent European Americans w...

    journal_title:Addiction biology

    pub_type: 杂志文章


    authors: Karpyak VM,Biernacka JM,Weg MW,Stevens SR,Cunningham JM,Mrazek DA,Black JL

    更新日期:2010-01-01 00:00:00