Abstract:
BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or history of heavy drinking. The aim of this paper was to examine the association of cortical GABA+ concentration with severity of liver disease (including markers of liver injury) and other clinical characteristics in alcohol patients. METHODS:Proton magnetic resonance spectroscopy (1 H-MRS), from the parietal lobe, was analyzed to yield absolute concentration of GABA in 24 alcohol-dependent individuals. Diagnosis of ALD, markers of liver injury, severity of liver disease (Model for End-Stage Liver Disease [MELD]), and alcohol history were assessed. Covariates included concurrent medication, age, and recent alcohol consumption. RESULTS:Multiple linear regression revealed that GABA+ concentration was significantly predicted by MELD scores (F = 5.02, R2 = 0.59, P = 0.01; MELD: B = -0.63, P = 0.02), when controlling for covariates concurrent medication, age, and recent alcohol consumption. CONCLUSION:Severity of ALD is associated with lower cortical concentrations of GABA+. These results may explain variations in response to the GABAB agonist, baclofen, in the alcohol-dependent population.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Morley KC,Lagopoulos J,Logge W,Baillie A,Adams C,Haber PSdoi
10.1111/adb.12702subject
Has Abstractpub_date
2020-01-01 00:00:00pages
e12702issue
1eissn
1355-6215issn
1369-1600journal_volume
25pub_type
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