Association of polymorphism in the alcohol dehydrogenase 2 gene with alcohol-related organ injuries, especially liver cirrhosis.

abstract：:Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...

journal_title：Addiction biology

authors： Lydon-Staley DM,MacLean RR,Falk EB,Bassett DS,Wilson SJ

更新日期：2021-01-28 00:00:00

abstract：:Previous studies on acetaldehyde dehydrogenase 2 (ALDH2) focused on drinking behavior or alcoholism because the ALDH2*2 allele protects against the risk of developing alcoholism. The mechanism provides that the ALDH2 gene's protective effect is also involved in dopamine metabolism. The interaction of the ALDH2 gene wi...

journal_title：Addiction biology

authors： Lu RB,Lee JF,Huang SY,Lee SY,Chang YH,Kuo PH,Chen SL,Chen SH,Chu CH,Lin WW,Wu PL,Ko HC

更新日期：2012-09-01 00:00:00

abstract：:Addiction is characterized by a persistent loss of behavioral control resulting in insensitivity to negative feedback and abnormal decision-making. Here, we investigated the influence of methamphetamine (METH)-paired contextual cues on decision-making in rats. Choice between goal-directed actions was sensitive to outc...

journal_title：Addiction biology

authors： Furlong TM,Supit AS,Corbit LH,Killcross S,Balleine BW

更新日期：2017-01-01 00:00:00

abstract：:We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a...

journal_title：Addiction biology

authors： Sommer C,Birkenstock J,Garbusow M,Obst E,Schad DJ,Bernhardt N,Huys QM,Wurst FM,Weinmann W,Heinz A,Smolka MN,Zimmermann US

更新日期：2020-01-01 00:00:00

abstract：:The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist such as an abused drug phencyclidine (PCP) causes the induction of heat shock protein HSP-70, a sensitive marker of neuronal injury, in the retrosplenial cortex of rat brain. The present study was undertaken to examine the role of a -amino-3- hydroxy-...

journal_title：Addiction biology

authors： Narita N,Hashimoto K,Tomitaka S,Minabe Y,Yamazaki K

更新日期：1997-01-01 00:00:00

abstract：:Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CU...

journal_title：Addiction biology

authors： Hindocha C,Freeman TP,Schafer G,Gardner C,Bloomfield MAP,Bramon E,Morgan CJA,Curran HV

更新日期：2020-05-01 00:00:00

abstract：:Several studies show that substance dependence disorders are characterized by an enhanced processing of substance-related stimuli. The present study was designed to examine the association between craving levels and selective processing of drug cues in cocaine-dependent patients using event-related brain potentials (E...

journal_title：Addiction biology

authors： Franken IH,Dietvorst RC,Hesselmans M,Franzek EJ,van de Wetering BJ,Van Strien JW

更新日期：2008-09-01 00:00:00

abstract：:The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = ...

journal_title：Addiction biology

authors： Schneider U,Paetzold W,Eronat V,Huber TJ,Seifert J,Wiese B,Emrich HM

更新日期：2000-01-01 00:00:00

abstract：:The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...

journal_title：Addiction biology

authors： Gamaleddin I,Wertheim C,Zhu AZ,Coen KM,Vemuri K,Makryannis A,Goldberg SR,Le Foll B

更新日期：2012-01-01 00:00:00

abstract：:We demonstrated that the genotype of the variable number tandem repeats (VNTRs) in the linked polymorphic region (LPR) of the 5' promoter and in the intron 2 (Stin2) transcriptional regulatory domains of the serotonin transporter SLC6A4 gene determined its promoter interactions with transcription factors and co-activa...

journal_title：Addiction biology

authors： Vasiliou SA,Ali FR,Haddley K,Cardoso MC,Bubb VJ,Quinn JP

更新日期：2012-01-01 00:00:00

abstract：:The World Health Organization estimates a 12-month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age-related functional decline. According to neuropathologi...

journal_title：Addiction biology

authors： Zhao Q,Pfefferbaum A,Podhajsky S,Pohl KM,Sullivan EV

更新日期：2020-05-01 00:00:00

abstract：:Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...

journal_title：Addiction biology

authors： Pettorruso M,Martinotti G,Cocciolillo F,De Risio L,Cinquino A,Di Nicola M,Camardese G,Migliara G,Moccia L,Conte E,Janiri L,Di Giuda D

更新日期：2019-09-01 00:00:00

abstract：:Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF1 and CRF2 receptor mRNA. Furthermore, the ascending NI relaxin-3 syst...

journal_title：Addiction biology

authors： Walker LC,Kastman HE,Koeleman JA,Smith CM,Perry CJ,Krstew EV,Gundlach AL,Lawrence AJ

更新日期：2017-11-01 00:00:00

abstract：:Abstract Twenty-eight Wistar rats treated orally with 20% ethanol solution, were divided into two groups: adult group (n = 19) and aged group (n = 9) consisting of animals aged 4 and 12 months, respectively, at the beginning of the treatment. Neurons from the basal nucleus region were counted and the percentage of cho...

journal_title：Addiction biology

authors： Fernandes PA,Ribeiro AM,Pereira RF,Marra HL,Pittella JE

更新日期：2002-01-01 00:00:00

abstract：:Cocaine self-administration in rats results in dysfunctional neuroadaptations in the prelimbic (PrL) cortex during early abstinence. Central to these adaptations is decreased phospho-extracellular signal-regulated kinase (p-ERK), which plays a key role in cocaine seeking. Normalizing ERK phosphorylation in the PrL cor...

journal_title：Addiction biology

authors： Siemsen BM,Lombroso PJ,McGinty JF

更新日期：2018-01-01 00:00:00

abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...

journal_title：Addiction biology

authors： Wang JQ,McGinty JF

更新日期：1999-04-01 00:00:00

abstract：:Nicotine withdrawal is associated with subtle working memory deficits that predict subsequent relapse. We examined the neural substrates underlying these processes in treatment-seeking smokers, and explored the moderating influence of age on abstinence-induced alterations in brain activity and performance. Sixty-three...

journal_title：Addiction biology

authors： Falcone M,Wileyto EP,Ruparel K,Gerraty RT,LaPrate L,Detre JA,Gur R,Loughead J,Lerman C

更新日期：2014-09-01 00:00:00

abstract：:Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...

journal_title：Addiction biology

authors： Gerra G,Garofano L,Pellegrini C,Bosari S,Zaimovic A,Moi G,Avanzini P,Talarico E,Gardini F,Donnini C

更新日期：2005-09-01 00:00:00

abstract：:The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...

journal_title：Addiction biology

authors： Herman AI,Conner TS,Anton RF,Gelernter J,Kranzler HR,Covault J

更新日期：2011-01-01 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:We measured hippocampal volumes and cognitive functioning in crack-cocaine and crack-cocaine/alcoholdependent subjects (abstinent approximately 10-12 weeks) compared to age-matched controls. Cognitive function was evaluated using the computerized MicroCog Assessment of Cognitive Functioning (which includes tests of ex...

journal_title：Addiction biology

authors： DI Sclafani V,Truran DL,Bloomer C,Tolou-Shams M,Clark HW,Norman D,Hannauer D,Fein G

更新日期：1998-07-01 00:00:00

abstract：:Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...

journal_title：Addiction biology

authors： Roldán M,Echeverry-Alzate V,Bühler KM,Sánchez-Diez IJ,Calleja-Conde J,Olmos P,Boehm SL,Maldonado R,Rodríguez de Fonseca F,Santiago C,Gómez-Gallego F,Giné E,López-Moreno JA

更新日期：2018-09-01 00:00:00

abstract：:Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...

journal_title：Addiction biology

authors： Bellentani S,Saccoccio G,Masutti F,Giacca M,Miglioli L,Monzoni A,Tiribelli C

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or hi...

journal_title：Addiction biology

authors： Morley KC,Lagopoulos J,Logge W,Baillie A,Adams C,Haber PS

更新日期：2020-01-01 00:00:00

abstract：:Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...

journal_title：Addiction biology

authors： Lawn W,Mithchener L,Freeman TP,Benattayallah A,Bisby JA,Wall MB,Dodds CM,Curran HV,Morgan CJA

更新日期：2020-07-01 00:00:00

abstract：:Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...

journal_title：Addiction biology

authors： Wu Y,Li Y,Yang X,Sui N

更新日期：2014-01-01 00:00:00

abstract：:Recent studies in animal models have shown that the nociceptin system, comprising nociceptin (or OFQ/N, encoded by PNOC) and the nociceptin receptor (an opioid receptor-like protein encoded by OPRL1), may be involved in alcohol and other drug reward pathways. To determine whether the nociceptin system is associated wi...

journal_title：Addiction biology

authors： Xuei X,Flury-Wetherill L,Almasy L,Bierut L,Tischfield J,Schuckit M,Nurnberger JI Jr,Foroud T,Edenberg HJ

更新日期：2008-03-01 00:00:00

abstract：:The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...

journal_title：Addiction biology

authors： Fragale JE,James MH,Aston-Jones G

更新日期：2020-08-14 00:00:00

abstract：:Selected ion flow tube mass spectrometry (SIFT-MS) has been used to measure simultaneously the concentrations of both carbon disulphide and acetone in exhaled breath following the ingestion of a single dose of disulfiram (Antabuse). Carbon disulphide is a product of the metabolism of disulfiram and is excreted mainly ...

journal_title：Addiction biology

authors： Bloor RN,Spanĕl P,Smith D

更新日期：2006-06-01 00:00:00

abstract：:The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...

journal_title：Addiction biology

authors： Adinoff B,Harris TS,Gu H,Stein EA

更新日期：2017-05-01 00:00:00