Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats.

abstract：:Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing m...

journal_title：Addiction biology

authors： Lao-Peregrín C,Ballesteros JJ,Fernández M,Zamora-Moratalla A,Saavedra A,Gómez Lázaro M,Pérez-Navarro E,Burks D,Martín ED

更新日期：2017-11-01 00:00:00

abstract：:Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result of altered gene expression in various brain regions. The present study investigated brain region-specific changes in the pattern and magnitude of gene expression immediately following chronic intermittent ethanol (CIE) exposure...

journal_title：Addiction biology

authors： Melendez RI,McGinty JF,Kalivas PW,Becker HC

更新日期：2012-03-01 00:00:00

abstract：:The controversy over the relationship between heroin addiction and hepatocellular dysfunction was examined by assay of serum activities of aspartate and alanine aminotransferases, total protein, albumin and globulin in 48 chronic heroin smokers and 33 controls. Biliary secretion in the addicts was compared to controls...

journal_title：Addiction biology

authors： Banerjee D,Sarkar NK

更新日期：1996-01-01 00:00:00

abstract：:Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial ...

journal_title：Addiction biology

authors： Wuo-Silva R,Fukushiro DF,Borçoi AR,Fernandes HA,Procópio-Souza R,Hollais AW,Santos R,Ribeiro LT,Corrêa JM,Talhati F,Saito LP,Aramini TC,Kameda SR,Bittencourt LR,Tufik S,Frussa-Filho R

更新日期：2011-10-01 00:00:00

abstract：:Early relapse is common after opiate withdrawal and deprives addicts of important opportunities to develop new, opiate-free cognitive-behavioural habits. The oral opiate antagonist naltrexone (NTX) significantly reduces relapse only when rigorously supervised and/or probation-linked. Simple but effective NTX implants,...

journal_title：Addiction biology

authors： Foster J,Brewer C,Steele T

更新日期：2003-06-01 00:00:00

abstract：:Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction ...

journal_title：Addiction biology

authors： Barrós-Loscertales A,Costumero V,Rosell-Negre P,Fuentes-Claramonte P,Llopis-Llacer JJ,Bustamante JC

更新日期：2020-07-01 00:00:00

abstract：:The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neur...

journal_title：Addiction biology

authors： Chu NN,Xia W,Yu P,Hu L,Zhang R,Cui CL

更新日期：2008-03-01 00:00:00

abstract：:A major finding--that (-)-trans-Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB(1) and CB(2), and that...

journal_title：Addiction biology

authors： Pertwee RG

更新日期：2008-06-01 00:00:00

abstract：:Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the study of voluntary binge-like drinking (BD) in outbred Long-Evans rats by combining intermittent access to 20% ethanol in a two-bottle choice (IA2BC) paradigm t...

journal_title：Addiction biology

authors： Sauton P,Deschamps C,Jeanblanc V,Pierrefiche O,Jeanblanc J,Naassila M

更新日期：2020-12-16 00:00:00

abstract：:Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...

journal_title：Addiction biology

authors： Markou A,Li J,Tse K,Li X

更新日期：2018-01-01 00:00:00

abstract：:Several genetic polymorphisms have been reported to be associated with alcohol withdrawal seizures (AWS) and delirium tremens (DT). To replicate and further explore these findings, we investigated the effects of 12 previously reported candidate genetic variations in two groups of alcohol-dependent European Americans w...

journal_title：Addiction biology

authors： Karpyak VM,Biernacka JM,Weg MW,Stevens SR,Cunningham JM,Mrazek DA,Black JL

更新日期：2010-01-01 00:00:00

abstract：:The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...

journal_title：Addiction biology

authors： Herman AI,Conner TS,Anton RF,Gelernter J,Kranzler HR,Covault J

更新日期：2011-01-01 00:00:00

abstract：:Nicotine withdrawal is associated with subtle working memory deficits that predict subsequent relapse. We examined the neural substrates underlying these processes in treatment-seeking smokers, and explored the moderating influence of age on abstinence-induced alterations in brain activity and performance. Sixty-three...

journal_title：Addiction biology

authors： Falcone M,Wileyto EP,Ruparel K,Gerraty RT,LaPrate L,Detre JA,Gur R,Loughead J,Lerman C

更新日期：2014-09-01 00:00:00

abstract：:Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...

journal_title：Addiction biology

authors： Dunn KE,Weerts EM,Huhn AS,Schroeder JR,Tompkins DA,Bigelow GE,Strain EC

更新日期：2020-01-01 00:00:00

abstract：:Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol dependence syndrome (ADS) in East Asian populations. Recently, attention has focused on the role of these SNPs in determining ADS risk in European populations. To ...

journal_title：Addiction biology

authors： Way M,McQuillin A,Saini J,Ruparelia K,Lydall GJ,Guerrini I,Ball D,Smith I,Quadri G,Thomson AD,Kasiakogia-Worlley K,Cherian R,Gunwardena P,Rao H,Kottalgi G,Patel S,Hillman A,Douglas E,Qureshi SY,Reynolds G,Jauhar S

更新日期：2015-05-01 00:00:00

abstract：:Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...

journal_title：Addiction biology

authors： Loftén A,Adermark L,Ericson M,Söderpalm B

更新日期：2020-08-13 00:00:00

abstract：:Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...

journal_title：Addiction biology

authors： Bellentani S,Saccoccio G,Masutti F,Giacca M,Miglioli L,Monzoni A,Tiribelli C

更新日期：2000-07-01 00:00:00

abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...

journal_title：Addiction biology

authors： Wang JQ,McGinty JF

更新日期：1999-04-01 00:00:00

abstract：:The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...

journal_title：Addiction biology

authors： Wang YJ,Huang P,Blendy JA,Liu-Chen LY

更新日期：2014-05-01 00:00:00

abstract：:Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...

journal_title：Addiction biology

authors： Pavon FJ,Serrano A,Sidhpura N,Polis I,Stouffer D,de Fonseca FR,Cravatt BF,Martin-Fardon R,Parsons LH

更新日期：2018-03-01 00:00:00

abstract：:Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CU...

journal_title：Addiction biology

authors： Hindocha C,Freeman TP,Schafer G,Gardner C,Bloomfield MAP,Bramon E,Morgan CJA,Curran HV

更新日期：2020-05-01 00:00:00

abstract：:Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...

journal_title：Addiction biology

authors： Roldán M,Echeverry-Alzate V,Bühler KM,Sánchez-Diez IJ,Calleja-Conde J,Olmos P,Boehm SL,Maldonado R,Rodríguez de Fonseca F,Santiago C,Gómez-Gallego F,Giné E,López-Moreno JA

更新日期：2018-09-01 00:00:00

abstract：:Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...

journal_title：Addiction biology

authors： Lenz B,Mühle C,Cohort Study on Substance Use Risk Factors.,Kornhuber J

更新日期：2020-07-01 00:00:00

abstract：:Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of ...

journal_title：Addiction biology

authors： Gamaleya N,Tronnikov S,Ulyanova L,Klimova S,Dmitrieva I

更新日期：1996-01-01 00:00:00

abstract：:Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin....

journal_title：Addiction biology

authors： Stefanik MT,Moussawi K,Kupchik YM,Smith KC,Miller RL,Huff ML,Deisseroth K,Kalivas PW,LaLumiere RT

更新日期：2013-01-01 00:00:00

abstract：:The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The...

journal_title：Addiction biology

authors： Vinod KY,Maccioni P,Garcia-Gutierrez MS,Femenia T,Xie S,Carai MA,Manzanares J,Cooper TB,Hungund BL,Colombo G

更新日期：2012-01-01 00:00:00

abstract：:The World Health Organization estimates a 12-month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age-related functional decline. According to neuropathologi...

journal_title：Addiction biology

authors： Zhao Q,Pfefferbaum A,Podhajsky S,Pohl KM,Sullivan EV

更新日期：2020-05-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) regulates a variety of physiological processes, and several studies have explored the role of BDNF in addiction-related brain regions like the nucleus accumbens core (NAcore). We sought to understand the rapid effects of endogenous BDNF on cocaine seeking. Rats were trained to ...

journal_title：Addiction biology

authors： Bobadilla AC,Garcia-Keller C,Chareunsouk V,Hyde J,Medina Camacho D,Heinsbroek JA,Kalivas PW

更新日期：2019-09-01 00:00:00

abstract：:The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist such as an abused drug phencyclidine (PCP) causes the induction of heat shock protein HSP-70, a sensitive marker of neuronal injury, in the retrosplenial cortex of rat brain. The present study was undertaken to examine the role of a -amino-3- hydroxy-...

journal_title：Addiction biology

authors： Narita N,Hashimoto K,Tomitaka S,Minabe Y,Yamazaki K

更新日期：1997-01-01 00:00:00

abstract：:Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...

journal_title：Addiction biology

authors： Ledesma JC,Rodríguez-Arias M,Gavito AL,Sánchez-Pérez AM,Viña J,Medina Vera D,Rodríguez de Fonseca F,Miñarro J

更新日期：2021-01-01 00:00:00