Abstract:
:Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-induced nicotine-seeking behavior under different withdrawal conditions in rats with a history of nicotine self-administration. We found that non-reinforced operant responding during cue-induced nicotine seeking after different periods of withdrawal from nicotine exhibited an inverted U-shaped curve, with higher levels of responding after 7-21 days of withdrawal than those after 1-day withdrawal. Cue-induced nicotine-seeking responding is long lasting and persists even after 42 days of forced withdrawal in the home cages. Interestingly, repeated testing of cue-induced nicotine seeking at different withdrawal time points (1, 7, 14, 21 and 42 days) in the same individual alleviated responding as compared with the between-subjects assessment. Furthermore, extinction training during nicotine withdrawal significantly decreased cue-induced reinstatement of nicotine-seeking behavior. Together, profound time-dependent incubation of cue-induced craving in nicotine-experienced rats were observed. In addition, repeated cue exposure or extinction training decreases cue-induced craving. The demonstration of incubation of nicotine craving phenomenon in both rat and human studies provides support for the translational potential of therapeutic targets for relapse uncovered through mechanism studies in rats.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Markou A,Li J,Tse K,Li Xdoi
10.1111/adb.12480subject
Has Abstractpub_date
2018-01-01 00:00:00pages
111-119issue
1eissn
1355-6215issn
1369-1600journal_volume
23pub_type
杂志文章abstract::The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12946
更新日期:2020-08-14 00:00:00
abstract::α-Synuclein has recently been implicated in the pathophysiology of alcohol abuse due to its role in dopaminergic neurotransmission. In these studies, genetic variability in the α-synuclein gene influences its expression which may contribute to susceptibility to chronic alcohol abuse. Real-time PCR was used to quantify...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00495.x
更新日期:2014-05-01 00:00:00
abstract::Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inabilit...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12684
更新日期:2020-01-01 00:00:00
abstract::Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhe...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12428
更新日期:2017-11-01 00:00:00
abstract::The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210071289
更新日期:2000-01-01 00:00:00
abstract::Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin....
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00479.x
更新日期:2013-01-01 00:00:00
abstract::Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971542
更新日期:1999-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00311.x
更新日期:2012-03-01 00:00:00
abstract::Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12802
更新日期:2020-07-01 00:00:00
abstract::This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...
journal_title:Addiction biology
pub_type: 评论,杂志文章
doi:10.1111/adb.12265
更新日期:2017-01-01 00:00:00
abstract::Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12779
更新日期:2020-07-01 00:00:00
abstract::Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cogn...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12737
更新日期:2020-03-01 00:00:00
abstract::Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impair...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12584
更新日期:2019-03-01 00:00:00
abstract::The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00484.x
更新日期:2014-05-01 00:00:00
abstract::Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF1 and CRF2 receptor mRNA. Furthermore, the ascending NI relaxin-3 syst...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12426
更新日期:2017-11-01 00:00:00
abstract::The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12247
更新日期:2016-05-01 00:00:00
abstract::The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim, male and female C57BL/6J mice (n = 60 per sex) were exposed to the drinking in the dark (DID) model for 4 weeks (DID-1 to DID-4). Dose-response effects of CBD on t...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12765
更新日期:2020-05-01 00:00:00
abstract::Voluntary oral ethanol consumption in rodents is generally limited by strong taste-aversion in these species. Historically, this has been overcome by combining ethanol with a sweetener, typically sucrose or saccharine, and then slowly 'fading' away the sweetener. While useful in most instances, this approach has not p...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00260.x
更新日期:2012-01-01 00:00:00
abstract::Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12356
更新日期:2017-05-01 00:00:00
abstract::Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12890
更新日期:2020-03-05 00:00:00
abstract::Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12042
更新日期:2014-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621961000125046
更新日期:1996-01-01 00:00:00
abstract::The neural and genetic factors underlying chronic tolerance to alcohol are currently unclear. The GluN2A N-methyl-D-aspartate receptors (NMDAR) subunit and the NMDAR-anchoring protein PSD-95 mediate acute alcohol intoxication and represent putative mechanisms mediating tolerance. We found that chronic intermittent eth...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12110
更新日期:2015-03-01 00:00:00
abstract::In keeping with its ability to control the mesoaccumbens dopamine (DA) pathway, the serotonin2C receptor (5-HT2C R) plays a key role in mediating the behavioral and neurochemical effects of drugs of abuse. Studies assessing the influence of 5-HT2C R agonists on cocaine-induced responses have suggested that 5-HT2C Rs c...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12137
更新日期:2015-05-01 00:00:00
abstract::Adolescent alcohol use is associated with increased risk for alcohol use disorders later in life; therefore, identifying biomarkers for initiation of heavy alcohol use, such as individual differences in the development of white-matter microstructure, may inform prevention strategies that improve public health. This pr...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12767
更新日期:2020-05-01 00:00:00
abstract::Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CU...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12762
更新日期:2020-05-01 00:00:00
abstract::The World Health Organization estimates a 12-month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age-related functional decline. According to neuropathologi...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12746
更新日期:2020-05-01 00:00:00
abstract::Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12820
更新日期:2020-07-01 00:00:00
abstract::Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00367.x
更新日期:2012-09-01 00:00:00
abstract::Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subj...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12246
更新日期:2016-05-01 00:00:00