Abstract：
:Several genetic polymorphisms have been reported to be associated with alcohol withdrawal seizures (AWS) and delirium tremens (DT). To replicate and further explore these findings, we investigated the effects of 12 previously reported candidate genetic variations in two groups of alcohol-dependent European Americans with a history of withdrawal, which differed according to the presence (n = 112) or absence (n = 92) of AWS and/or DT. Associations of AWS and/or DT with the genomic and clinical characteristics and gene-gene interaction effects were investigated using logistic regression models. None of the polymorphisms were significantly associated with AWS/DT after correction for multiple testing. However, we found a significant interaction effect of the SLC6A4 promoter polymorphism (5-HTTLPR) and DRD2 exon 8 single nucleotide polymorphism rs6276 on AWS and/or DT history (P = 0.009), which became more significant after adjustment for lifetime maximum number of drinks consumed per 24 hours (P < 0.001). Subsequent analysis revealed an even stronger association of the SLC6A4-DRD2 interaction with DT (P < 0.0001), which remained significant after Bonferroni correction. Results reveal decreased likelihood of DT in alcoholics that carry the DRD2 rs6276 G allele and SLC6A4 LL genotype. This study provides the first evidence to implicate the interaction between serotonin and dopamine neurotransmission in the etiology of DT. Replication is necessary to verify this potentially important finding.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Karpyak VM,Biernacka JM,Weg MW,Stevens SR,Cunningham JM,Mrazek DA,Black JLdoi
10.1111/j.1369-1600.2009.00183.xsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
23-34issue
1eissn
1355-6215issn
1369-1600pii
ADB183journal_volume
15pub_type
杂志文章abstract：:The habit of chewing fresh leaves and twigs of khat (Catha edulis) for their stimulating amphetamine-like effects is highly prevalent in East Africa and southwest on the Arabic peninsula. There is an extensive literature on khat providing information about its history, botany, production, geographical distribution, ch...
journal_title：Addiction biology
pub_type： 杂志文章,评审
doi：10.1080/13556210500353020
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journal_title：Addiction biology
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journal_title：Addiction biology
pub_type： 杂志文章,评审
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journal_title：Addiction biology
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doi：10.1111/j.1369-1600.2010.00227.x
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journal_title：Addiction biology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210500123217
更新日期：2005-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Addiction biology
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