Abstract:
:Combined anorectic-alcohol misuse is a prevalent problem in Brazil. In order to understand better the interactive effects of ethanol (EtOH) and mazindol (MZ), we examined the effects of EtOH (1.2 g/kg) and MZ (5.0 mg/kg) given alone or in combination, on mouse behaviour. The results indicate that EtOH plus MZ induces a significantly greater increase in locomotor activity of mice than either constituent alone. However, no such interactive effect was detected in the place preference and in the plus-maze test of anxiety. MZ given alone was found to increase the locomotor activity and to possess rewarding effects as measured in the place preference conditioning. At the dose selected, EtOH alone showed anxiolytic and rewarding effects. These results provide some evidence of increased behavioural effects in mice due to combinations of EtOH and MZ. These findings suggest that a major determinant of combined anorectic-alcohol misuse may be the increased stimulating effects produced by such combination.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Gevaerd MS,Takahashi RNdoi
10.1080/1355621961000124926subject
Has Abstractpub_date
1996-01-01 00:00:00pages
303-7issue
3eissn
1355-6215issn
1369-1600pii
8UWEH71YWVBLMQW4journal_volume
1pub_type
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journal_title:Addiction biology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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