Striatal presynaptic dopaminergic dysfunction in gambling disorder: A 123 I-FP-CIT SPECT study.

abstract：:We demonstrated that the genotype of the variable number tandem repeats (VNTRs) in the linked polymorphic region (LPR) of the 5' promoter and in the intron 2 (Stin2) transcriptional regulatory domains of the serotonin transporter SLC6A4 gene determined its promoter interactions with transcription factors and co-activa...

journal_title：Addiction biology

authors： Vasiliou SA,Ali FR,Haddley K,Cardoso MC,Bubb VJ,Quinn JP

更新日期：2012-01-01 00:00:00

abstract：:Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...

journal_title：Addiction biology

authors： Mori T,Rahmadi M,Yoshizawa K,Itoh T,Shibasaki M,Suzuki T

更新日期：2014-05-01 00:00:00

abstract：:Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic opioid administration are thought to contribute to the pathogenesis and persistence of opiate addiction. In order to identify candidate genes involved in these neuroadaptations, we utilized a behavior-genetics strategy designed ...

journal_title：Addiction biology

authors： Tapocik JD,Luu TV,Mayo CL,Wang BD,Doyle E,Lee AD,Lee NH,Elmer GI

更新日期：2013-05-01 00:00:00

abstract：:Intravenous drug addiction is known to be associated with an inordinate morbidity and mortality. As our previous report had identified an immune phenotype consistent with accelerated ageing, we wished to investigate how much of this change may have been related to chronic viral hepatitis. A total of 12 409 clinical pa...

journal_title：Addiction biology

authors： Reece AS

更新日期：2009-04-01 00:00:00

abstract：:Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present ...

journal_title：Addiction biology

authors： Dijkstra BA,De Jong CA,Bluschke SM,Krabbe PF,van der Staak CP

更新日期：2007-06-01 00:00:00

abstract：:Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dep...

journal_title：Addiction biology

authors： Murray DE,Durazzo TC,Schmidt TP,Murray TA,Abé C,Guydish J,Meyerhoff DJ

更新日期：2018-03-01 00:00:00

abstract：:Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...

journal_title：Addiction biology

authors： Henry BL,Minassian A,Perry W

更新日期：2012-05-01 00:00:00

abstract：:The total concentration of THC has been monitored in cannabis preparations sold in Dutch coffee shops since 1999. This annual monitoring was issued by the Ministry of Health after reports of increased potency. The level of the main psychoactive compound, Delta9-tetrahydrocannabinol (THC), is measured in marijuana and ...

journal_title：Addiction biology

authors： Pijlman FT,Rigter SM,Hoek J,Goldschmidt HM,Niesink RJ

更新日期：2005-06-01 00:00:00

abstract：:Abstract Methamphetamine (METH)-induced dopaminergic neurotoxicity is thought to be associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recently, we have reported that copper/zinc(CuZn)-superoxide dismutase transgenic mice are resistant to METH-induced neurotoxicity. In...

journal_title：Addiction biology

authors： Ali SF,Haung P,Itzhak Y

更新日期：2000-07-01 00:00:00

abstract：:One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice. C57BL/6J mice were trained in operant conditioning maintain...

journal_title：Addiction biology

authors： Burokas A,Gutiérrez-Cuesta J,Martín-García E,Maldonado R

更新日期：2012-07-01 00:00:00

abstract：:The World Health Organization estimates a 12-month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age-related functional decline. According to neuropathologi...

journal_title：Addiction biology

authors： Zhao Q,Pfefferbaum A,Podhajsky S,Pohl KM,Sullivan EV

更新日期：2020-05-01 00:00:00

abstract：:The capacity of the liver to synthesize insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) may be compromised by alcohol. The characteristics of IGFBP-3 variants obtained from healthy individuals and patients with alcoholic cirrhosis (ALC) were compared. Concanavalin A (Con A) affinity electrophore...

journal_title：Addiction biology

authors： Nedić O,Nikolić JA,Prisić S,Acimovic J,hajdukovic-Dragojlovic L

更新日期：2003-03-01 00:00:00

abstract：:Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol dependence syndrome (ADS) in East Asian populations. Recently, attention has focused on the role of these SNPs in determining ADS risk in European populations. To ...

journal_title：Addiction biology

authors： Way M,McQuillin A,Saini J,Ruparelia K,Lydall GJ,Guerrini I,Ball D,Smith I,Quadri G,Thomson AD,Kasiakogia-Worlley K,Cherian R,Gunwardena P,Rao H,Kottalgi G,Patel S,Hillman A,Douglas E,Qureshi SY,Reynolds G,Jauhar S

更新日期：2015-05-01 00:00:00

abstract：:Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...

journal_title：Addiction biology

authors： Loftén A,Adermark L,Ericson M,Söderpalm B

更新日期：2020-08-13 00:00:00

abstract：:The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...

journal_title：Addiction biology

authors： Zhang X,Nielsen DA,Domingo CB,Shorter DI,Nielsen EM,Kosten TR

更新日期：2019-05-01 00:00:00

abstract：:Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction ...

journal_title：Addiction biology

authors： Barrós-Loscertales A,Costumero V,Rosell-Negre P,Fuentes-Claramonte P,Llopis-Llacer JJ,Bustamante JC

更新日期：2020-07-01 00:00:00

abstract：:Ethanol oxidation to acetaldehyde and next to acetate is accompanied by free radical generation. Free radicals can affect cell integrity when antioxidant mechanisms are no longer able to cope with the free radical generation observed in ethanol intoxication. Natural antioxidants are particularly useful in such a situa...

journal_title：Addiction biology

authors： Skrzydlewska E,Ostrowska J,Stankiewicz A,Farbiszewski R

更新日期：2002-07-01 00:00:00

abstract：:Major advances have been made in understanding nicotine addiction and smoking behaviour in recent years. In particular, evidence for the relative importance of genetic and environmental effects on smoking initiation and persistence has emerged from behaviour genetic studies. These data have supported evidence from mol...

journal_title：Addiction biology

authors： Munafò M,Johnstone E,Murphy M,Walton R

更新日期：2001-04-01 00:00:00

abstract：:Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...

journal_title：Addiction biology

authors： Hwa LS,Shimamoto A,Kayyali T,Norman KJ,Valentino RJ,DeBold JF,Miczek KA

更新日期：2016-01-01 00:00:00

abstract：:Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...

journal_title：Addiction biology

authors： Roldán M,Echeverry-Alzate V,Bühler KM,Sánchez-Diez IJ,Calleja-Conde J,Olmos P,Boehm SL,Maldonado R,Rodríguez de Fonseca F,Santiago C,Gómez-Gallego F,Giné E,López-Moreno JA

更新日期：2018-09-01 00:00:00

abstract：:The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...

journal_title：Addiction biology

authors： Wang YJ,Huang P,Blendy JA,Liu-Chen LY

更新日期：2014-05-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) regulates a variety of physiological processes, and several studies have explored the role of BDNF in addiction-related brain regions like the nucleus accumbens core (NAcore). We sought to understand the rapid effects of endogenous BDNF on cocaine seeking. Rats were trained to ...

journal_title：Addiction biology

authors： Bobadilla AC,Garcia-Keller C,Chareunsouk V,Hyde J,Medina Camacho D,Heinsbroek JA,Kalivas PW

更新日期：2019-09-01 00:00:00

abstract：:Associations between nicotine in cigarettes and food consumption may alter the incentive value of food such that food cue-reactivity is exaggerated during abstinence from smoking. This effect may contribute to the weight gain associated with cessation of smoking. We examined the effects of nicotine (0.4 mg/kg base sub...

journal_title：Addiction biology

authors： Grimm JW,Ratliff C,North K,Barnes J,Collins S

更新日期：2012-05-01 00:00:00

abstract：:Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...

journal_title：Addiction biology

authors： Vaquero L,Cámara E,Sampedro F,Pérez de Los Cobos J,Batlle F,Fabregas JM,Sales JA,Cervantes M,Ferrer X,Lazcano G,Rodríguez-Fornells A,Riba J

更新日期：2017-05-01 00:00:00

abstract：:Although adolescents are a group heavily targeted by the e-cigarette industry, research in cue-reactivity has not previously examined adolescents' behavioral and neural responses to e-cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n...

journal_title：Addiction biology

authors： Chen Y,Fowler CH,Papa VB,Lepping RJ,Brucks MG,Fox AT,Martin LE

更新日期：2018-03-01 00:00:00

abstract：:Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...

journal_title：Addiction biology

authors： Ehinger Y,Phamluong K,Darevesky D,Welman M,Moffat JJ,Sakhai SA,Whiteley EL,Berger AL,Laguesse S,Farokhnia M,Leggio L,Lordkipanidzé M,Ron D

更新日期：2020-03-05 00:00:00

abstract：:Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...

journal_title：Addiction biology

authors： Wetherill RR,Jagannathan K,Lohoff FW,Ehrman R,O'Brien CP,Childress AR,Franklin TR

更新日期：2014-03-01 00:00:00

abstract：:The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consum...

journal_title：Addiction biology

authors： Suchankova P,Nilsson S,von der Pahlen B,Santtila P,Sandnabba K,Johansson A,Jern P,Engel JA,Jerlhag E

更新日期：2016-03-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...

journal_title：Addiction biology

authors： Navarrete F,Rubio G,Manzanares J

更新日期：2014-09-01 00:00:00

abstract：:Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...

journal_title：Addiction biology

authors： Ledesma JC,Rodríguez-Arias M,Gavito AL,Sánchez-Pérez AM,Viña J,Medina Vera D,Rodríguez de Fonseca F,Miñarro J

更新日期：2021-01-01 00:00:00