Role of peroxynitrite in methamphetamine-induced dopaminergic neurotoxicity and sensitization in mice.

abstract：:Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor increasing vulnerability involves reduced expression of the serotonin transporter (5-HTT). Human s...

journal_title：Addiction biology

authors： Karel P,Van der Toorn A,Vanderschuren L,Guo C,Sadighi Alvandi M,Reneman L,Dijkhuizen R,Verheij MMM,Homberg JR

更新日期：2020-01-01 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...

journal_title：Addiction biology

authors： Mori T,Rahmadi M,Yoshizawa K,Itoh T,Shibasaki M,Suzuki T

更新日期：2014-05-01 00:00:00

abstract：:The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = ...

journal_title：Addiction biology

authors： Schneider U,Paetzold W,Eronat V,Huber TJ,Seifert J,Wiese B,Emrich HM

更新日期：2000-01-01 00:00:00

abstract：:The effectiveness of using amphetamine isomer ratios to determine individual compliance with a Dexedrine (dexamphetamine, Celltech, Slough, UK) treatment regimen for the maintenance and detoxification from amphetamine abuse has been audited. The calculation of l/d-amphetamine isomer ratios in urine has been shown prev...

journal_title：Addiction biology

authors： George S

更新日期：2003-12-01 00:00:00

abstract：:The capacity of the liver to synthesize insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) may be compromised by alcohol. The characteristics of IGFBP-3 variants obtained from healthy individuals and patients with alcoholic cirrhosis (ALC) were compared. Concanavalin A (Con A) affinity electrophore...

journal_title：Addiction biology

authors： Nedić O,Nikolić JA,Prisić S,Acimovic J,hajdukovic-Dragojlovic L

更新日期：2003-03-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) regulates a variety of physiological processes, and several studies have explored the role of BDNF in addiction-related brain regions like the nucleus accumbens core (NAcore). We sought to understand the rapid effects of endogenous BDNF on cocaine seeking. Rats were trained to ...

journal_title：Addiction biology

authors： Bobadilla AC,Garcia-Keller C,Chareunsouk V,Hyde J,Medina Camacho D,Heinsbroek JA,Kalivas PW

更新日期：2019-09-01 00:00:00

abstract：:Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be involved in the pathophysiology of several disorders related to smoking and may be relevant for the pathophysiology of nico...

journal_title：Addiction biology

authors： Cohrs S,Rodenbeck A,Riemann D,Szagun B,Jaehne A,Brinkmeyer J,Gründer G,Wienker T,Diaz-Lacava A,Mobascher A,Dahmen N,Thuerauf N,Kornhuber J,Kiefer F,Gallinat J,Wagner M,Kunz D,Grittner U,Winterer G

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or hi...

journal_title：Addiction biology

authors： Morley KC,Lagopoulos J,Logge W,Baillie A,Adams C,Haber PS

更新日期：2020-01-01 00:00:00

abstract：:Cannabinoid type 1 (CB1) receptors control the motivational properties and reinforcing effects of nicotine. Indeed, peripheral administration of a CB1 receptor antagonist dramatically decreases both nicotine taking and seeking. However, the neural substrates through which the cannabinoid CB1 receptors regulate the vol...

journal_title：Addiction biology

authors： Simonnet A,Cador M,Caille S

更新日期：2013-11-01 00:00:00

abstract：:Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...

journal_title：Addiction biology

authors： Wu Y,Li Y,Yang X,Sui N

更新日期：2014-01-01 00:00:00

abstract：:The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...

journal_title：Addiction biology

authors： McLachlan-Troup N,Taylor GW,Trathen BC

更新日期：2001-07-01 00:00:00

abstract：:Chemical compounds that target dopamine (DA) D1 or D3 receptors have shown promise as potential interventions in animal models of cue-induced relapse. However, undesirable side effects or pharmacodynamic profiles have limited the advancement of new compounds in preclinical studies when administered as independent trea...

journal_title：Addiction biology

authors： Ewing ST,Dorcely C,Maidi R,Paker G,Schelbaum E,Ranaldi R

更新日期：2021-01-25 00:00:00

abstract：:Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic opioid administration are thought to contribute to the pathogenesis and persistence of opiate addiction. In order to identify candidate genes involved in these neuroadaptations, we utilized a behavior-genetics strategy designed ...

journal_title：Addiction biology

authors： Tapocik JD,Luu TV,Mayo CL,Wang BD,Doyle E,Lee AD,Lee NH,Elmer GI

更新日期：2013-05-01 00:00:00

abstract：:Voluntary oral ethanol consumption in rodents is generally limited by strong taste-aversion in these species. Historically, this has been overcome by combining ethanol with a sweetener, typically sucrose or saccharine, and then slowly 'fading' away the sweetener. While useful in most instances, this approach has not p...

journal_title：Addiction biology

authors： McCool BA,Chappell AM

更新日期：2012-01-01 00:00:00

abstract：:We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two...

journal_title：Addiction biology

authors： Selvas A,Coria SM,Kastanauskaite A,Fernaud-Espinosa I,DeFelipe J,Ambrosio E,Miguéns M

更新日期：2017-01-01 00:00:00

abstract：:To gain a better insight into the alterations of brain function after chronic ethanol, we measured the release of various neurotransmitters from nerve terminals of cortex and hippocampus isolated fm rats chronically fed with ethanol. The K+-evoked release of [3H]acetylcholine (ACh), f[H]dopamine (DA), [3H] glutamate(G...

journal_title：Addiction biology

authors： Sabriá J,Torres D,Pastó M,Peralba JM,Allali-Hassani A,Parés X

更新日期：2003-09-01 00:00:00

abstract：:The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...

journal_title：Addiction biology

authors： Fragale JE,James MH,Aston-Jones G

更新日期：2020-08-14 00:00:00

abstract：:In our society every second polytraumatized patient is a chronic alcoholic. A patient's alcohol-related history is often unavailable and laboratory markers are not sensitive or specific enough to detect alcohol-dependent patients who are at risk of developing alcohol withdrawal syndrome (AWS) during their post-traumat...

journal_title：Addiction biology

authors： Spies CD,Rommelspacher H,Winkler T,Müller C,Brummer G,Funk T,Berger G,Fell M,Blum S,Specht M,Hannemann L,Schaffartzik W

更新日期：1996-01-01 00:00:00

abstract：:The class I hepatic alcohol dehydrogenases (ADHs) are primarily responsible for ethanol metabolism in humans. Genetic polymorphism at the ADH2 locus results in the inheritance of isozymes of strikingly different catalytic properties. In European and Caucasian American populations, β1, which is encoded by ADH2(1) , is ...

journal_title：Addiction biology

authors： Yamauchi M

更新日期：1998-04-01 00:00:00

abstract：:Previous work suggests a role for dopamine D3-like receptors in psychostimulant reinforcement. The development of new compounds acting selectively at dopamine D3 receptors has opened new possibilities to explore the role of these receptors in animal models of psychostimulant dependence. Here we investigated whether th...

journal_title：Addiction biology

authors： Orio L,Wee S,Newman AH,Pulvirenti L,Koob GF

更新日期：2010-07-01 00:00:00

abstract：:Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...

journal_title：Addiction biology

authors： Carbo-Gas M,Vazquez-Sanroman D,Aguirre-Manzo L,Coria-Avila GA,Manzo J,Sanchis-Segura C,Miquel M

更新日期：2014-01-01 00:00:00

abstract：:The genetic and environmental contributions to differences in response to ethanol have been examined widely using inbred strains, selected lines and genetically engineered (transgenic and 'knock-out') animals. In addition, recombinant inbred strains have been used to identify QTLs (chromosomal regions) associated with...

journal_title：Addiction biology

authors： Hoffman P,Tabakoff B

更新日期：2005-03-01 00:00:00

abstract：:Erythroycte delta aminolevulinic acid dehydratase (ALAD) has been suggested as a marker for detecting recent alcohol intake. Unlike other markers, ALAD activity decreases after alcohol intake. Review of the literature suggests that the main interest in this marker is because it increases rapidly after withdrawal. The ...

journal_title：Addiction biology

authors： Aubin HJ,Laureaux C,Tilikete S,Gillet C,Lepetitcorps A,Nguyen T,Troupel S,Paille F,Barrucand D

更新日期：1997-04-01 00:00:00

abstract：:Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...

journal_title：Addiction biology

authors： Rolland B,Dricot L,Creupelandt C,Maurage P,De Timary P

更新日期：2020-03-01 00:00:00

abstract：:Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...

journal_title：Addiction biology

authors： Pettorruso M,Martinotti G,Cocciolillo F,De Risio L,Cinquino A,Di Nicola M,Camardese G,Migliara G,Moccia L,Conte E,Janiri L,Di Giuda D

更新日期：2019-09-01 00:00:00

abstract：:Addiction is characterized by a persistent loss of behavioral control resulting in insensitivity to negative feedback and abnormal decision-making. Here, we investigated the influence of methamphetamine (METH)-paired contextual cues on decision-making in rats. Choice between goal-directed actions was sensitive to outc...

journal_title：Addiction biology

authors： Furlong TM,Supit AS,Corbit LH,Killcross S,Balleine BW

更新日期：2017-01-01 00:00:00

abstract：:Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...

journal_title：Addiction biology

authors： de Miguel E,Vekovischeva O,Kuokkanen K,Vesajoki M,Paasikoski N,Kaskinoro J,Myllymäki M,Lainiola M,Janhunen SK,Hyytiä P,Linden AM,Korpi ER

更新日期：2019-11-01 00:00:00

abstract：:Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or preven...

journal_title：Addiction biology

authors： Simon-O'Brien E,Alaux-Cantin S,Warnault V,Buttolo R,Naassila M,Vilpoux C

更新日期：2015-07-01 00:00:00

abstract：:Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the study of voluntary binge-like drinking (BD) in outbred Long-Evans rats by combining intermittent access to 20% ethanol in a two-bottle choice (IA2BC) paradigm t...

journal_title：Addiction biology

authors： Sauton P,Deschamps C,Jeanblanc V,Pierrefiche O,Jeanblanc J,Naassila M

更新日期：2020-12-16 00:00:00