Strong increase in total delta-THC in cannabis preparations sold in Dutch coffee shops.

abstract：:Voluntary oral ethanol consumption in rodents is generally limited by strong taste-aversion in these species. Historically, this has been overcome by combining ethanol with a sweetener, typically sucrose or saccharine, and then slowly 'fading' away the sweetener. While useful in most instances, this approach has not p...

journal_title：Addiction biology

authors： McCool BA,Chappell AM

更新日期：2012-01-01 00:00:00

abstract：:It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subje...

journal_title：Addiction biology

authors： Loeber S,Vollstädt-Klein S,von der Goltz C,Flor H,Mann K,Kiefer F

更新日期：2009-04-01 00:00:00

abstract：:The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...

journal_title：Addiction biology

authors： Adinoff B,Harris TS,Gu H,Stein EA

更新日期：2017-05-01 00:00:00

abstract：:Alcohol exposure during fetal and early postnatal development can lead to an increased incidence of later life adult-onset diseases. Examples include central nervous system dysfunction, depression, anxiety, hyperactivity, and an inability to deal with stressful situations, increased infection and cancer. Direct effect...

journal_title：Addiction biology

authors： Sarkar DK

更新日期：2016-01-01 00:00:00

abstract：:The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist such as an abused drug phencyclidine (PCP) causes the induction of heat shock protein HSP-70, a sensitive marker of neuronal injury, in the retrosplenial cortex of rat brain. The present study was undertaken to examine the role of a -amino-3- hydroxy-...

journal_title：Addiction biology

authors： Narita N,Hashimoto K,Tomitaka S,Minabe Y,Yamazaki K

更新日期：1997-01-01 00:00:00

abstract：:Ethanol oxidation to acetaldehyde and next to acetate is accompanied by free radical generation. Free radicals can affect cell integrity when antioxidant mechanisms are no longer able to cope with the free radical generation observed in ethanol intoxication. Natural antioxidants are particularly useful in such a situa...

journal_title：Addiction biology

authors： Skrzydlewska E,Ostrowska J,Stankiewicz A,Farbiszewski R

更新日期：2002-07-01 00:00:00

abstract：:Ketamine, a non-competitive N-methyl-D-aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when ...

journal_title：Addiction biology

authors： Sun L,Li Q,Li Q,Zhang Y,Liu D,Jiang H,Pan F,Yew DT

更新日期：2014-03-01 00:00:00

abstract：:Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of ...

journal_title：Addiction biology

authors： Gamaleya N,Tronnikov S,Ulyanova L,Klimova S,Dmitrieva I

更新日期：1996-01-01 00:00:00

abstract：:The genetic and environmental contributions to differences in response to ethanol have been examined widely using inbred strains, selected lines and genetically engineered (transgenic and 'knock-out') animals. In addition, recombinant inbred strains have been used to identify QTLs (chromosomal regions) associated with...

journal_title：Addiction biology

authors： Hoffman P,Tabakoff B

更新日期：2005-03-01 00:00:00

abstract：:In utero exposure of fetuses to tobacco is associated with reduced birth weight. We hypothesized that this may be due to the toxic effect of carbon monoxide (CO) from tobacco, which has previously been described to damage mitochondria in non-pregnant adult smokers. Maternal peripheral blood mononuclear cells (PBMCs), ...

journal_title：Addiction biology

authors： Garrabou G,Hernàndez AS,Catalán García M,Morén C,Tobías E,Córdoba S,López M,Figueras F,Grau JM,Cardellach F

更新日期：2016-01-01 00:00:00

abstract：:Recent studies in animal models have shown that the nociceptin system, comprising nociceptin (or OFQ/N, encoded by PNOC) and the nociceptin receptor (an opioid receptor-like protein encoded by OPRL1), may be involved in alcohol and other drug reward pathways. To determine whether the nociceptin system is associated wi...

journal_title：Addiction biology

authors： Xuei X,Flury-Wetherill L,Almasy L,Bierut L,Tischfield J,Schuckit M,Nurnberger JI Jr,Foroud T,Edenberg HJ

更新日期：2008-03-01 00:00:00

abstract：:Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction ...

journal_title：Addiction biology

authors： Barrós-Loscertales A,Costumero V,Rosell-Negre P,Fuentes-Claramonte P,Llopis-Llacer JJ,Bustamante JC

更新日期：2020-07-01 00:00:00

abstract：:We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two...

journal_title：Addiction biology

authors： Selvas A,Coria SM,Kastanauskaite A,Fernaud-Espinosa I,DeFelipe J,Ambrosio E,Miguéns M

更新日期：2017-01-01 00:00:00

abstract：:The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking. We investigated the role of adult hippocampal neur...

journal_title：Addiction biology

authors： Luján MÁ,Cantacorps L,Valverde O

更新日期：2020-07-01 00:00:00

abstract：:Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational u...

journal_title：Addiction biology

authors： Aarde SM,Angrish D,Barlow DJ,Wright MJ Jr,Vandewater SA,Creehan KM,Houseknecht KL,Dickerson TJ,Taffe MA

更新日期：2013-09-01 00:00:00

abstract：:The controversy over the relationship between heroin addiction and hepatocellular dysfunction was examined by assay of serum activities of aspartate and alanine aminotransferases, total protein, albumin and globulin in 48 chronic heroin smokers and 33 controls. Biliary secretion in the addicts was compared to controls...

journal_title：Addiction biology

authors： Banerjee D,Sarkar NK

更新日期：1996-01-01 00:00:00

abstract：:Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...

journal_title：Addiction biology

authors： Hwa LS,Shimamoto A,Kayyali T,Norman KJ,Valentino RJ,DeBold JF,Miczek KA

更新日期：2016-01-01 00:00:00

abstract：:Copy number variations (CNVs) can alter the DNA sequence in blocks ranging from kilobases to megabases, involving more total nucleotides than single nucleotide polymorphisms. Yet, its impact in humans is far from fully understood. In this study, we investigate the relationship of genome-wide CNVs with brain function e...

journal_title：Addiction biology

authors： Liu J,Calhoun VD,Chen J,Claus ED,Hutchison KE

更新日期：2013-05-01 00:00:00

abstract：:Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inabilit...

journal_title：Addiction biology

authors： Hagerty SL,YorkWilliams SL,Bidwell LC,Weiland BJ,Sabbineni A,Blaine SK,Bryan AD,Hutchison KE

更新日期：2020-01-01 00:00:00

abstract：:Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-depe...

journal_title：Addiction biology

authors： Zhang R,Jiang G,Tian J,Qiu Y,Wen X,Zalesky A,Li M,Ma X,Wang J,Li S,Wang T,Li C,Huang R

更新日期：2016-05-01 00:00:00

abstract：:Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial ...

journal_title：Addiction biology

authors： Wuo-Silva R,Fukushiro DF,Borçoi AR,Fernandes HA,Procópio-Souza R,Hollais AW,Santos R,Ribeiro LT,Corrêa JM,Talhati F,Saito LP,Aramini TC,Kameda SR,Bittencourt LR,Tufik S,Frussa-Filho R

更新日期：2011-10-01 00:00:00

abstract：:Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...

journal_title：Addiction biology

authors： Schote AB,Jäger K,Kroll SL,Vonmoos M,Hulka LM,Preller KH,Meyer J,Grünblatt E,Quednow BB

更新日期：2019-07-01 00:00:00

abstract：:Cannabinoid type 1 (CB1) receptors control the motivational properties and reinforcing effects of nicotine. Indeed, peripheral administration of a CB1 receptor antagonist dramatically decreases both nicotine taking and seeking. However, the neural substrates through which the cannabinoid CB1 receptors regulate the vol...

journal_title：Addiction biology

authors： Simonnet A,Cador M,Caille S

更新日期：2013-11-01 00:00:00

abstract：:Reduced executive control is one of the central components of model on the development and maintenance of Internet gaming disorder (IGD). Among the various executive control problems, high impulsivity has consistently been associated with IGD. We performed voxel-based morphometric analysis with diffeomorphic anatomica...

journal_title：Addiction biology

authors： Lee D,Namkoong K,Lee J,Jung YC

更新日期：2018-09-01 00:00:00

abstract：:Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...

journal_title：Addiction biology

authors： Wetherill RR,Jagannathan K,Lohoff FW,Ehrman R,O'Brien CP,Childress AR,Franklin TR

更新日期：2014-03-01 00:00:00

abstract：:Early relapse is common after opiate withdrawal and deprives addicts of important opportunities to develop new, opiate-free cognitive-behavioural habits. The oral opiate antagonist naltrexone (NTX) significantly reduces relapse only when rigorously supervised and/or probation-linked. Simple but effective NTX implants,...

journal_title：Addiction biology

authors： Foster J,Brewer C,Steele T

更新日期：2003-06-01 00:00:00

abstract：:A major finding--that (-)-trans-Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB(1) and CB(2), and that...

journal_title：Addiction biology

authors： Pertwee RG

更新日期：2008-06-01 00:00:00

abstract：:Several studies have emphasized the role of learning in the development of rapid and chronic tolerances. Recently, it was shown that the NMDA antagonists MK-801(dizocilpine) and ketamine block the development of tolerance to ethanol in rats submitted to tilt-plane apparatus. The present study examines the generality o...

journal_title：Addiction biology

authors： Barreto PS,Lemos T,Morato GS

更新日期：1998-01-01 00:00:00

abstract：:Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic opioid administration are thought to contribute to the pathogenesis and persistence of opiate addiction. In order to identify candidate genes involved in these neuroadaptations, we utilized a behavior-genetics strategy designed ...

journal_title：Addiction biology

authors： Tapocik JD,Luu TV,Mayo CL,Wang BD,Doyle E,Lee AD,Lee NH,Elmer GI

更新日期：2013-05-01 00:00:00

abstract：:Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...

journal_title：Addiction biology

authors： Solecki WB,Szklarczyk K,Pradel K,Kwiatkowska K,Dobrzański G,Przewłocki R

更新日期：2018-03-01 00:00:00