Abnormal gray matter volume and impulsivity in young adults with Internet gaming disorder.

abstract：:Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor increasing vulnerability involves reduced expression of the serotonin transporter (5-HTT). Human s...

journal_title：Addiction biology

authors： Karel P,Van der Toorn A,Vanderschuren L,Guo C,Sadighi Alvandi M,Reneman L,Dijkhuizen R,Verheij MMM,Homberg JR

更新日期：2020-01-01 00:00:00

abstract：:Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...

journal_title：Addiction biology

authors： Pettorruso M,Martinotti G,Cocciolillo F,De Risio L,Cinquino A,Di Nicola M,Camardese G,Migliara G,Moccia L,Conte E,Janiri L,Di Giuda D

更新日期：2019-09-01 00:00:00

abstract：:Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...

journal_title：Addiction biology

authors： Ledesma JC,Rodríguez-Arias M,Gavito AL,Sánchez-Pérez AM,Viña J,Medina Vera D,Rodríguez de Fonseca F,Miñarro J

更新日期：2021-01-01 00:00:00

abstract：:The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The...

journal_title：Addiction biology

authors： Vinod KY,Maccioni P,Garcia-Gutierrez MS,Femenia T,Xie S,Carai MA,Manzanares J,Cooper TB,Hungund BL,Colombo G

更新日期：2012-01-01 00:00:00

abstract：:Associations between nicotine in cigarettes and food consumption may alter the incentive value of food such that food cue-reactivity is exaggerated during abstinence from smoking. This effect may contribute to the weight gain associated with cessation of smoking. We examined the effects of nicotine (0.4 mg/kg base sub...

journal_title：Addiction biology

authors： Grimm JW,Ratliff C,North K,Barnes J,Collins S

更新日期：2012-05-01 00:00:00

abstract：:Abstract Methamphetamine (METH)-induced dopaminergic neurotoxicity is thought to be associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recently, we have reported that copper/zinc(CuZn)-superoxide dismutase transgenic mice are resistant to METH-induced neurotoxicity. In...

journal_title：Addiction biology

authors： Ali SF,Haung P,Itzhak Y

更新日期：2000-07-01 00:00:00

abstract：:Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of ...

journal_title：Addiction biology

authors： Liu L,Yip SW,Zhang JT,Wang LJ,Shen ZJ,Liu B,Ma SS,Yao YW,Fang XY

更新日期：2017-05-01 00:00:00

abstract：:Smoking-related cues elicit craving and mesocorticolimbic brain activation in smokers. Severity of nicotine dependence seems to moderate cue reactivity, but the direction and mechanisms of its influence remains unclear. Although tobacco control policies demand a ban on tobacco advertising, cue reactivity studies in sm...

journal_title：Addiction biology

authors： Vollstädt-Klein S,Kobiella A,Bühler M,Graf C,Fehr C,Mann K,Smolka MN

更新日期：2011-01-01 00:00:00

abstract：:Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila ...

journal_title：Addiction biology

authors： Schmitt RE,Messick MR,Shell BC,Dunbar EK,Fang HF,Shelton KL,Venton BJ,Pletcher SD,Grotewiel M

更新日期：2020-07-01 00:00:00

abstract：:The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...

journal_title：Addiction biology

authors： Herman AI,Conner TS,Anton RF,Gelernter J,Kranzler HR,Covault J

更新日期：2011-01-01 00:00:00

abstract：:Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in the treatment of drug dependence and drug withdrawal. Oxytocin reduces methamphetamine self-administration, conditioned place preference and hyperactivity in rodents. However, it is unclear how oxytocin acts in the brain to prod...

journal_title：Addiction biology

authors： Carson DS,Hunt GE,Guastella AJ,Barber L,Cornish JL,Arnold JC,Boucher AA,McGregor IS

更新日期：2010-10-01 00:00:00

abstract：:Selected ion flow tube mass spectrometry (SIFT-MS) has been used to measure simultaneously the concentrations of both carbon disulphide and acetone in exhaled breath following the ingestion of a single dose of disulfiram (Antabuse). Carbon disulphide is a product of the metabolism of disulfiram and is excreted mainly ...

journal_title：Addiction biology

authors： Bloor RN,Spanĕl P,Smith D

更新日期：2006-06-01 00:00:00

abstract：:The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...

journal_title：Addiction biology

authors： Zhang X,Nielsen DA,Domingo CB,Shorter DI,Nielsen EM,Kosten TR

更新日期：2019-05-01 00:00:00

abstract：:Smoking withdrawal is associated with significant deficits in the ability to initiate and maintain attention for extended periods of time (i.e. sustained attention; SA). However, the effects of smoking abstinence on the temporal dynamics of neurocognition during SA have not been evaluated. Twenty adult smokers underwe...

journal_title：Addiction biology

authors： Kozink RV,Lutz AM,Rose JE,Froeliger B,McClernon FJ

更新日期：2010-10-01 00:00:00

abstract：:The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consum...

journal_title：Addiction biology

authors： Suchankova P,Nilsson S,von der Pahlen B,Santtila P,Sandnabba K,Johansson A,Jern P,Engel JA,Jerlhag E

更新日期：2016-03-01 00:00:00

abstract：:We demonstrated that the genotype of the variable number tandem repeats (VNTRs) in the linked polymorphic region (LPR) of the 5' promoter and in the intron 2 (Stin2) transcriptional regulatory domains of the serotonin transporter SLC6A4 gene determined its promoter interactions with transcription factors and co-activa...

journal_title：Addiction biology

authors： Vasiliou SA,Ali FR,Haddley K,Cardoso MC,Bubb VJ,Quinn JP

更新日期：2012-01-01 00:00:00

abstract：:Based on the knowledge that alcohol misuse causes a multitude of diseases and increased mortality, this systematic review examines whether a reduction of the individual alcohol consumption can contribute to a minimization of health risks within a harm reduction approach. In fact, the reviewed 63 studies indicate that ...

journal_title：Addiction biology

authors： Charlet K,Heinz A

更新日期：2017-09-01 00:00:00

abstract：:The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...

journal_title：Addiction biology

authors： Adinoff B,Harris TS,Gu H,Stein EA

更新日期：2017-05-01 00:00:00

abstract：:Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investig...

journal_title：Addiction biology

authors： Martin-Rodriguez JF,Ruiz-Veguilla M,Alvarez de Toledo P,Aizpurua-Olaizola O,Zarandona I,Canal-Rivero M,Rodriguez-Baena A,Mir P

更新日期：2020-04-23 00:00:00

abstract：:Erythroycte delta aminolevulinic acid dehydratase (ALAD) has been suggested as a marker for detecting recent alcohol intake. Unlike other markers, ALAD activity decreases after alcohol intake. Review of the literature suggests that the main interest in this marker is because it increases rapidly after withdrawal. The ...

journal_title：Addiction biology

authors： Aubin HJ,Laureaux C,Tilikete S,Gillet C,Lepetitcorps A,Nguyen T,Troupel S,Paille F,Barrucand D

更新日期：1997-04-01 00:00:00

abstract：:Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug-predictive cues and is thought to be a critical substrate for drug craving, but the downstream neural circuit effectors of the IC that med...

journal_title：Addiction biology

authors： Girven KS,Aroni S,Navarrete J,Marino RAM,McKeon PN,Cheer JF,Sparta DR

更新日期：2020-08-20 00:00:00

abstract：:The genetic and environmental contributions to differences in response to ethanol have been examined widely using inbred strains, selected lines and genetically engineered (transgenic and 'knock-out') animals. In addition, recombinant inbred strains have been used to identify QTLs (chromosomal regions) associated with...

journal_title：Addiction biology

authors： Hoffman P,Tabakoff B

更新日期：2005-03-01 00:00:00

abstract：:Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of ...

journal_title：Addiction biology

authors： Gamaleya N,Tronnikov S,Ulyanova L,Klimova S,Dmitrieva I

更新日期：1996-01-01 00:00:00

abstract：:The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...

journal_title：Addiction biology

authors： Wolff CB,Peters TJ,Keating J,Gardner WN

更新日期：1999-04-01 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:Animal research supports a central role for corticotropin-releasing factor (CRF) in actions of ethanol on brain function. An examination of alcohol consumption in adolescents reported a significant genotype x environment (G x E) interaction involving rs1876831, a corticotropin-releasing hormone receptor 1 (CRHR1) poly...

journal_title：Addiction biology

authors： Nelson EC,Agrawal A,Pergadia ML,Wang JC,Whitfield JB,Saccone FS,Kern J,Grant JD,Schrage AJ,Rice JP,Montgomery GW,Heath AC,Goate AM,Martin NG,Madden PA

更新日期：2010-01-01 00:00:00

abstract：:Alcohol exposure during fetal and early postnatal development can lead to an increased incidence of later life adult-onset diseases. Examples include central nervous system dysfunction, depression, anxiety, hyperactivity, and an inability to deal with stressful situations, increased infection and cancer. Direct effect...

journal_title：Addiction biology

authors： Sarkar DK

更新日期：2016-01-01 00:00:00

abstract：:Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...

journal_title：Addiction biology

authors： Loftén A,Adermark L,Ericson M,Söderpalm B

更新日期：2020-08-13 00:00:00

abstract：:Withdrawal of opioid drugs leads to a cluster of unpleasant symptoms in dependent subjects. These symptoms are stimulatory in nature and oppose the acute, inhibitory effects of opiates. The conventional theory that explains the opioid withdrawal syndrome assumes that chronic usage of opioid drugs activates compensator...

journal_title：Addiction biology

authors： Rubovitch V,Pick CG,Sarne Y

更新日期：2009-09-01 00:00:00

abstract：:Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dep...

journal_title：Addiction biology

authors： Murray DE,Durazzo TC,Schmidt TP,Murray TA,Abé C,Guydish J,Meyerhoff DJ

更新日期：2018-03-01 00:00:00