Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.

abstract：:The effectiveness of using amphetamine isomer ratios to determine individual compliance with a Dexedrine (dexamphetamine, Celltech, Slough, UK) treatment regimen for the maintenance and detoxification from amphetamine abuse has been audited. The calculation of l/d-amphetamine isomer ratios in urine has been shown prev...

journal_title：Addiction biology

authors： George S

更新日期：2003-12-01 00:00:00

abstract：:Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...

journal_title：Addiction biology

authors： Kim M,Custodio RJ,Botanas CJ,de la Peña JB,Sayson LV,Abiero A,Ryoo ZY,Cheong JH,Kim HJ

更新日期：2019-09-01 00:00:00

abstract：:Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...

journal_title：Addiction biology

authors： Gerra G,Garofano L,Pellegrini C,Bosari S,Zaimovic A,Moi G,Avanzini P,Talarico E,Gardini F,Donnini C

更新日期：2005-09-01 00:00:00

abstract：:Adolescent alcohol use is associated with increased risk for alcohol use disorders later in life; therefore, identifying biomarkers for initiation of heavy alcohol use, such as individual differences in the development of white-matter microstructure, may inform prevention strategies that improve public health. This pr...

journal_title：Addiction biology

authors： Morales AM,Jones SA,Harman G,Patching-Bunch J,Nagel BJ

更新日期：2020-05-01 00:00:00

abstract：:Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cogn...

journal_title：Addiction biology

authors： González B,Bernardi A,Torres OV,Jayanthi S,Gomez N,Sosa MH,García-Rill E,Urbano FJ,Cadet JL,Bisagno V

更新日期：2020-03-01 00:00:00

abstract：:Adolescence is characterized by considerable brain maturation that coincides with the development of adult behavior. Binge drinking is common during adolescence and can have deleterious effects on brain maturation because of the heightened neuroplasticity of the adolescent brain. Using an animal model of adolescent in...

journal_title：Addiction biology

authors： Vetreno RP,Yaxley R,Paniagua B,Crews FT

更新日期：2016-07-01 00:00:00

abstract：:Converging epidemiological studies show that a life-threatening event increases the incidence of posttraumatic stress disorder (PTSD), which carries 30% to 50% comorbidity with substance use disorders (SUDs). Such comorbidity results in greater drug use and poorer treatment outcomes. There is overlap between the endur...

journal_title：Addiction biology

authors： Garcia-Keller C,Smiley C,Monforton C,Melton S,Kalivas PW,Gass J

更新日期：2020-09-01 00:00:00

abstract：:The drive to eat is regulated by two compensatory brain pathways termed as homeostatic and hedonic. Hypothalamic orexinergic (ORX) neurons regulate metabolism, feeding and reward, thus controlling physiological and hedonic appetite. Circadian regulation of feeding, metabolism and rhythmic activity of ORX cells are dri...

journal_title：Addiction biology

authors： Feillet CA,Bainier C,Mateo M,Blancas-Velázquez A,Salaberry NL,Ripperger JA,Albrecht U,Mendoza J

更新日期：2017-03-01 00:00:00

abstract：:Copy number variations (CNVs) can alter the DNA sequence in blocks ranging from kilobases to megabases, involving more total nucleotides than single nucleotide polymorphisms. Yet, its impact in humans is far from fully understood. In this study, we investigate the relationship of genome-wide CNVs with brain function e...

journal_title：Addiction biology

authors： Liu J,Calhoun VD,Chen J,Claus ED,Hutchison KE

更新日期：2013-05-01 00:00:00

abstract：:Cannabinoid type 1 (CB1) receptors control the motivational properties and reinforcing effects of nicotine. Indeed, peripheral administration of a CB1 receptor antagonist dramatically decreases both nicotine taking and seeking. However, the neural substrates through which the cannabinoid CB1 receptors regulate the vol...

journal_title：Addiction biology

authors： Simonnet A,Cador M,Caille S

更新日期：2013-11-01 00:00:00

abstract：:Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...

journal_title：Addiction biology

authors： Lidö HH,Marston H,Ericson M,Söderpalm B

更新日期：2012-09-01 00:00:00

abstract：:Although adolescents are a group heavily targeted by the e-cigarette industry, research in cue-reactivity has not previously examined adolescents' behavioral and neural responses to e-cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n...

journal_title：Addiction biology

authors： Chen Y,Fowler CH,Papa VB,Lepping RJ,Brucks MG,Fox AT,Martin LE

更新日期：2018-03-01 00:00:00

abstract：:Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...

journal_title：Addiction biology

authors： Wetherill RR,Jagannathan K,Lohoff FW,Ehrman R,O'Brien CP,Childress AR,Franklin TR

更新日期：2014-03-01 00:00:00

abstract：:Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and funct...

journal_title：Addiction biology

authors： Kaarre O,Kallioniemi E,Könönen M,Tolmunen T,Kekkonen V,Kivimäki P,Heikkinen N,Ferreri F,Laukkanen E,Määttä S

更新日期：2018-01-01 00:00:00

abstract：:Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF1 and CRF2 receptor mRNA. Furthermore, the ascending NI relaxin-3 syst...

journal_title：Addiction biology

authors： Walker LC,Kastman HE,Koeleman JA,Smith CM,Perry CJ,Krstew EV,Gundlach AL,Lawrence AJ

更新日期：2017-11-01 00:00:00

abstract：:Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...

journal_title：Addiction biology

authors： Solecki WB,Szklarczyk K,Pradel K,Kwiatkowska K,Dobrzański G,Przewłocki R

更新日期：2018-03-01 00:00:00

abstract：:Chronic and excessive alcohol consumption induces defined myocardial lesions characterized by impaired structural, mechanical and biochemical features. The pathogenic mechanisms are unknown, although it is possible that protein adduct formation by reactive metabolites of ethanol may be a contributory process. Hitherto...

journal_title：Addiction biology

authors： Worrall S,Richardson PJ,Preedy VR

更新日期：2000-10-01 00:00:00

abstract：:Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...

journal_title：Addiction biology

authors： Pettorruso M,Martinotti G,Cocciolillo F,De Risio L,Cinquino A,Di Nicola M,Camardese G,Migliara G,Moccia L,Conte E,Janiri L,Di Giuda D

更新日期：2019-09-01 00:00:00

abstract：:Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be involved in the pathophysiology of several disorders related to smoking and may be relevant for the pathophysiology of nico...

journal_title：Addiction biology

authors： Cohrs S,Rodenbeck A,Riemann D,Szagun B,Jaehne A,Brinkmeyer J,Gründer G,Wienker T,Diaz-Lacava A,Mobascher A,Dahmen N,Thuerauf N,Kornhuber J,Kiefer F,Gallinat J,Wagner M,Kunz D,Grittner U,Winterer G

更新日期：2014-05-01 00:00:00

abstract：:The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...

journal_title：Addiction biology

authors： Fragale JE,James MH,Aston-Jones G

更新日期：2020-08-14 00:00:00

abstract：:Despite the fact that several data have supported the involvement of the cerebellum in the functional alterations observed after prolonged cocaine use, this brain structure has been traditionally ignored and excluded from the circuitry affected by addictive drugs. In the present study, we investigated the effects of a...

journal_title：Addiction biology

authors： Vazquez-Sanroman D,Leto K,Cerezo-Garcia M,Carbo-Gas M,Sanchis-Segura C,Carulli D,Rossi F,Miquel M

更新日期：2015-09-01 00:00:00

abstract：:The total concentration of THC has been monitored in cannabis preparations sold in Dutch coffee shops since 1999. This annual monitoring was issued by the Ministry of Health after reports of increased potency. The level of the main psychoactive compound, Delta9-tetrahydrocannabinol (THC), is measured in marijuana and ...

journal_title：Addiction biology

authors： Pijlman FT,Rigter SM,Hoek J,Goldschmidt HM,Niesink RJ

更新日期：2005-06-01 00:00:00

abstract：:Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...

journal_title：Addiction biology

authors： Markou A,Li J,Tse K,Li X

更新日期：2018-01-01 00:00:00

abstract：:Poor working memory is linked to future risk-taking behaviors. Lifelong risk of habitual drug use is highest in individuals who initiate use in early adolescence. We sought to determine in rats whether juvenile traits, specifically poor working memory and low salivary brain-derived neurotrophic factor (BDNF), are rela...

journal_title：Addiction biology

authors： Jordan CJ,Andersen SL

更新日期：2018-05-01 00:00:00

abstract：:Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug...

journal_title：Addiction biology

authors： Roura-Martínez D,Ucha M,Orihuel J,Ballesteros-Yáñez I,Castillo CA,Marcos A,Ambrosio E,Higuera-Matas A

更新日期：2020-03-01 00:00:00

abstract：:Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...

journal_title：Addiction biology

authors： Teichtahl H,Wang D,Cunnington D,Kronborg I,Goodman C,Prodromidis A,Drummer O

更新日期：2004-09-01 00:00:00

abstract：:Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...

journal_title：Addiction biology

authors： Rathitharan G,Truong J,Tong J,McCluskey T,Meyer JH,Mizrahi R,Warsh J,Rusjan P,Kennedy JL,Houle S,Kish SJ,Boileau I

更新日期：2021-01-01 00:00:00

abstract：:Cigarette smoke is a major risk factor for both coronary heart disease and peripheral vascular disease and has been reported to contain many oxidizing agents that lead to generation of free radicals. In this study, we investigated the levels of lipid peroxides (LPO) and antioxidant vitamins (C and E), total thiol cont...

journal_title：Addiction biology

authors： Gökkusu C,Ademoglu E,Tamer S,Alkan G

更新日期：2001-09-01 00:00:00

abstract：:Methamphetamine (METH) markedly increases dopamine (DA) release in the mesolimbic DA system, which plays an important role in mediating the reinforcing effects of METH. METH-induced DA release results in the formation of reactive oxygen species (ROS), leading to oxidative damage. We have recently reported that ROS are...

journal_title：Addiction biology

authors： Jang EY,Yang CH,Hedges DM,Kim SP,Lee JY,Ekins TG,Garcia BT,Kim HY,Nelson AC,Kim NJ,Steffensen SC

更新日期：2017-09-01 00:00:00

abstract：:Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...

journal_title：Addiction biology

authors： Karimi-Haghighi S,Dargahi L,Haghparast A

更新日期：2020-03-01 00:00:00