Abstract:
:Cannabinoid type 1 (CB1) receptors control the motivational properties and reinforcing effects of nicotine. Indeed, peripheral administration of a CB1 receptor antagonist dramatically decreases both nicotine taking and seeking. However, the neural substrates through which the cannabinoid CB1 receptors regulate the voluntary intake of nicotine remain to be elucidated. In the present study, we sought to determine whether central injections of a CB1 receptor antagonist delivered either into the ventral tegmental area (VTA) or the nucleus accumbens (NAC) may alter nicotine intravenous self-administration (IVSA). Rats were first trained to self-administer nicotine (30 μg/kg/0.1 ml). The effect of central infusions of the CB1 antagonist AM 251 (0, 1 and 10 μg/0.5 μl/side) on nicotine-taking behavior was then tested. Intra-VTA infusions of AM 251 dose dependently reduced IVSA with a significant decrease for the dose 10 μg/0.5 μl/side. Moreover, operant responding for water was unaltered by intra-VTA AM 251 at the same dose. Surprisingly, intra-NAC delivery of AM 251 did not alter nicotine behavior at all. These data suggest that in rats chronically exposed to nicotine IVSA, the cannabinoid CB1 receptors located in the VTA rather than in the NAC specifically control nicotine reinforcement and, subsequently, nicotine-taking behavior.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Simonnet A,Cador M,Caille Sdoi
10.1111/j.1369-1600.2012.00476.xsubject
Has Abstractpub_date
2013-11-01 00:00:00pages
930-6issue
6eissn
1355-6215issn
1369-1600journal_volume
18pub_type
杂志文章abstract::The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...
journal_title:Addiction biology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1369-1600.2009.00197.x
更新日期:2011-01-01 00:00:00
abstract::Alcoholic drinks are capable of triggering a wide range of allergic and allergic-like responses, including rhinitis, itching, facial swelling, headache, cough and asthma. Limited epidemiological data suggests that many individuals are affected and that sensitivities occur to a variety of drinks, including wine, beer a...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1080/1355621031000069828
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abstract::The total concentration of THC has been monitored in cannabis preparations sold in Dutch coffee shops since 1999. This annual monitoring was issued by the Ministry of Health after reports of increased potency. The level of the main psychoactive compound, Delta9-tetrahydrocannabinol (THC), is measured in marijuana and ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210500123217
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abstract::Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00367.x
更新日期:2012-09-01 00:00:00
abstract::Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12042
更新日期:2014-01-01 00:00:00
abstract::The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00484.x
更新日期:2014-05-01 00:00:00
abstract::Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subj...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12246
更新日期:2016-05-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12414
更新日期:2017-09-01 00:00:00
abstract::Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the bra...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12718
更新日期:2020-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12578
更新日期:2019-01-01 00:00:00
abstract::Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dep...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12523
更新日期:2018-03-01 00:00:00
abstract::Adolescence is characterized by considerable brain maturation that coincides with the development of adult behavior. Binge drinking is common during adolescence and can have deleterious effects on brain maturation because of the heightened neuroplasticity of the adolescent brain. Using an animal model of adolescent in...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12232
更新日期:2016-07-01 00:00:00
abstract::Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219871994
更新日期:1998-10-01 00:00:00
abstract::Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational u...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12038
更新日期:2013-09-01 00:00:00
abstract::Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12663
更新日期:2019-09-01 00:00:00
abstract::The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971641
更新日期:1999-04-01 00:00:00
abstract::This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...
journal_title:Addiction biology
pub_type: 评论,杂志文章
doi:10.1111/adb.12265
更新日期:2017-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12737
更新日期:2020-03-01 00:00:00
abstract::Previous work suggests a role for dopamine D3-like receptors in psychostimulant reinforcement. The development of new compounds acting selectively at dopamine D3 receptors has opened new possibilities to explore the role of these receptors in animal models of psychostimulant dependence. Here we investigated whether th...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00211.x
更新日期:2010-07-01 00:00:00
abstract::Nicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers' brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers'. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors ma...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00301.x
更新日期:2012-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12558
更新日期:2018-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210220139523
更新日期:2002-07-01 00:00:00
abstract::The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12361
更新日期:2017-05-01 00:00:00
abstract::It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic r...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12549
更新日期:2018-09-01 00:00:00
abstract::A major finding--that (-)-trans-Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB(1) and CB(2), and that...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/j.1369-1600.2008.00108.x
更新日期:2008-06-01 00:00:00
abstract::Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12779
更新日期:2020-07-01 00:00:00
abstract::Reduced executive control is one of the central components of model on the development and maintenance of Internet gaming disorder (IGD). Among the various executive control problems, high impulsivity has consistently been associated with IGD. We performed voxel-based morphometric analysis with diffeomorphic anatomica...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12552
更新日期:2018-09-01 00:00:00
abstract::Previous studies on acetaldehyde dehydrogenase 2 (ALDH2) focused on drinking behavior or alcoholism because the ALDH2*2 allele protects against the risk of developing alcoholism. The mechanism provides that the ALDH2 gene's protective effect is also involved in dopamine metabolism. The interaction of the ALDH2 gene wi...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00268.x
更新日期:2012-09-01 00:00:00
abstract::Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00341.x
更新日期:2011-10-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00423.x
更新日期:2012-07-01 00:00:00