Abstract:
:It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic resonance imaging cigarette cue exposure paradigm 2 hours after smoking, and then enrolled in a 9-week smoking cessation treatment program. Neural activation to smoking cues was measured in five a priori defined limbic/paralimbic regions previously implicated with cue reactivity across substances. These included regions of the ventral striatum, anterior cingulate cortex and amygdala. Cox proportional hazard modeling was conducted to predict the number of days to first smoking lapse by using neural activation in these regions. Greater neural activation during pre-treatment exposure to smoking cues in the right ventral striatum, the left amygdala, and the anterior cingulate was associated with longer periods of abstinence following cessation. A similar pattern was present for continuous abstinence for the full duration of treatment. While baseline levels of nicotine dependence were strongly associated with treatment outcome, activation in the right ventral striatum predicted duration of abstinence beyond level of nicotine dependence. These results suggest that pre-treatment reactivity to smoking cues in areas associated with cue reactivity may be associated with successfully maintaining abstinence during treatment. This is consistent with models that propose that as addiction becomes more severe, motivational processing shifts from regions that subserve reward salience and learning to regions responsible motor behavior and habit learning.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Owens MM,MacKillop J,Gray JC,Beach SRH,Stein MD,Niaura RS,Sweet LHdoi
10.1111/adb.12549subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1189-1199issue
5eissn
1355-6215issn
1369-1600journal_volume
23pub_type
杂志文章abstract::Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...
journal_title:Addiction biology
pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1080/13556210410001674103
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journal_title:Addiction biology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/adb.12172
更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00211.x
更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/adb.12751
更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12277
更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/adb.12504
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/13556210310001646411
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2009.00183.x
更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00123.x
更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00145.x
更新日期:2009-07-01 00:00:00