Abstract:
:Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila melanogaster as a model to investigate the effect of diet, an environmental factor, on ethanol sedation. Providing flies with diets high in yeast, a routinely used component of fly media, increased their resistance to ethanol sedation. The yeast-induced resistance to ethanol sedation occurred in several different genetic backgrounds, was observed in males and females, was elicited by yeast from different sources, was readily reversible, and was associated with increased nutrient intake as well as decreased internal ethanol levels. Inhibition of serotonergic neuron function using multiple independent genetic manipulations blocked the effect of yeast supplementation on ethanol sedation, nutrient intake, and internal ethanol levels. Our results demonstrate that yeast is a critical dietary component that influences ethanol sedation in flies and that serotonergic signaling is required for the effect of dietary yeast on nutrient intake, ethanol uptake/elimination, and ethanol sedation. Our studies establish the fly as a model for diet-induced changes in ethanol sedation and raise the possibility that serotonin might mediate the effect of diet on alcohol-related behavior in other species.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Schmitt RE,Messick MR,Shell BC,Dunbar EK,Fang HF,Shelton KL,Venton BJ,Pletcher SD,Grotewiel Mdoi
10.1111/adb.12779subject
Has Abstractpub_date
2020-07-01 00:00:00pages
e12779issue
4eissn
1355-6215issn
1369-1600journal_volume
25pub_type
杂志文章abstract::Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing m...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12433
更新日期:2017-11-01 00:00:00
abstract::Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210500223769
更新日期:2005-09-01 00:00:00
abstract::The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00314.x
更新日期:2012-01-01 00:00:00
abstract::Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.13001
更新日期:2021-01-28 00:00:00
abstract::A major finding--that (-)-trans-Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB(1) and CB(2), and that...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/j.1369-1600.2008.00108.x
更新日期:2008-06-01 00:00:00
abstract::Associations between nicotine in cigarettes and food consumption may alter the incentive value of food such that food cue-reactivity is exaggerated during abstinence from smoking. This effect may contribute to the weight gain associated with cessation of smoking. We examined the effects of nicotine (0.4 mg/kg base sub...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00436.x
更新日期:2012-05-01 00:00:00
abstract::Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12595
更新日期:2018-03-01 00:00:00
abstract::Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971407
更新日期:1999-10-01 00:00:00
abstract::This study employs an oral operant conditioning paradigm to evaluate the effects of repeated social defeat during adolescence on the reinforcing and motivational actions of ethanol in adult OF1 mice. Social interaction, emotional and cognitive behavioral aspects were also analyzed, and real-time polymerase chain react...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12184
更新日期:2016-01-01 00:00:00
abstract::Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12751
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or hi...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12702
更新日期:2020-01-01 00:00:00
abstract::Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12677
更新日期:2019-09-01 00:00:00
abstract::Several studies show that substance dependence disorders are characterized by an enhanced processing of substance-related stimuli. The present study was designed to examine the association between craving levels and selective processing of drug cues in cocaine-dependent patients using event-related brain potentials (E...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00100.x
更新日期:2008-09-01 00:00:00
abstract::The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971641
更新日期:1999-04-01 00:00:00
abstract::Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12632
更新日期:2019-07-01 00:00:00
abstract::Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12680
更新日期:2020-01-01 00:00:00
abstract::Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CU...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12762
更新日期:2020-05-01 00:00:00
abstract::Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12338
更新日期:2017-05-01 00:00:00
abstract::Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12663
更新日期:2019-09-01 00:00:00
abstract::Both the opioid antagonist naltrexone and corticotropin-releasing factor type-1 receptor (CRF-R1) antagonists have been investigated for the treatment of alcoholism. The current study examines the combination of naltrexone and CP154526 to reduce intermittent access ethanol drinking [intermittent access to alcohol (IAA...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12189
更新日期:2016-01-01 00:00:00
abstract::Abstract Twenty-eight Wistar rats treated orally with 20% ethanol solution, were divided into two groups: adult group (n = 19) and aged group (n = 9) consisting of animals aged 4 and 12 months, respectively, at the beginning of the treatment. Neurons from the basal nucleus region were counted and the percentage of cho...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/135562101200100571
更新日期:2002-01-01 00:00:00
abstract::Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12815
更新日期:2020-07-01 00:00:00
abstract::It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subje...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2009.00146.x
更新日期:2009-04-01 00:00:00
abstract::Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00507.x
更新日期:2014-03-01 00:00:00
abstract::The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2007.00092.x
更新日期:2008-03-01 00:00:00
abstract::Major advances have been made in understanding nicotine addiction and smoking behaviour in recent years. In particular, evidence for the relative importance of genetic and environmental effects on smoking initiation and persistence has emerged from behaviour genetic studies. These data have supported evidence from mol...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210020040181
更新日期:2001-04-01 00:00:00
abstract::The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12247
更新日期:2016-05-01 00:00:00
abstract::Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12042
更新日期:2014-01-01 00:00:00
abstract::Based on the knowledge that alcohol misuse causes a multitude of diseases and increased mortality, this systematic review examines whether a reduction of the individual alcohol consumption can contribute to a minimization of health risks within a harm reduction approach. In fact, the reviewed 63 studies indicate that ...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12414
更新日期:2017-09-01 00:00:00
abstract::The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00484.x
更新日期:2014-05-01 00:00:00