Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function.

Abstract:

:Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila melanogaster as a model to investigate the effect of diet, an environmental factor, on ethanol sedation. Providing flies with diets high in yeast, a routinely used component of fly media, increased their resistance to ethanol sedation. The yeast-induced resistance to ethanol sedation occurred in several different genetic backgrounds, was observed in males and females, was elicited by yeast from different sources, was readily reversible, and was associated with increased nutrient intake as well as decreased internal ethanol levels. Inhibition of serotonergic neuron function using multiple independent genetic manipulations blocked the effect of yeast supplementation on ethanol sedation, nutrient intake, and internal ethanol levels. Our results demonstrate that yeast is a critical dietary component that influences ethanol sedation in flies and that serotonergic signaling is required for the effect of dietary yeast on nutrient intake, ethanol uptake/elimination, and ethanol sedation. Our studies establish the fly as a model for diet-induced changes in ethanol sedation and raise the possibility that serotonin might mediate the effect of diet on alcohol-related behavior in other species.

journal_name

Addict Biol

journal_title

Addiction biology

authors

Schmitt RE,Messick MR,Shell BC,Dunbar EK,Fang HF,Shelton KL,Venton BJ,Pletcher SD,Grotewiel M

doi

10.1111/adb.12779

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

e12779

issue

4

eissn

1355-6215

issn

1369-1600

journal_volume

25

pub_type

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