解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.13001
更新日期:2021-01-28 00:00:00
abstract::Chemical compounds that target dopamine (DA) D1 or D3 receptors have shown promise as potential interventions in animal models of cue-induced relapse. However, undesirable side effects or pharmacodynamic profiles have limited the advancement of new compounds in preclinical studies when administered as independent trea...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12988
更新日期:2021-01-25 00:00:00
abstract::Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12883
更新日期:2021-01-01 00:00:00
abstract::Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12876
更新日期:2021-01-01 00:00:00
abstract::Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the study of voluntary binge-like drinking (BD) in outbred Long-Evans rats by combining intermittent access to 20% ethanol in a two-bottle choice (IA2BC) paradigm t...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12992
更新日期:2020-12-16 00:00:00
abstract::Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and the cystine-glutamate exchange protein xCT within the nucleus accumbens core (NAcore). N-acetylcysteine (NAC) has been shown to restore these proteins in a rodent model of drug addiction and relapse. How...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12797
更新日期:2020-09-01 00:00:00
abstract::Converging epidemiological studies show that a life-threatening event increases the incidence of posttraumatic stress disorder (PTSD), which carries 30% to 50% comorbidity with substance use disorders (SUDs). Such comorbidity results in greater drug use and poorer treatment outcomes. There is overlap between the endur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12798
更新日期:2020-09-01 00:00:00
abstract::Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug-predictive cues and is thought to be a critical substrate for drug craving, but the downstream neural circuit effectors of the IC that med...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12961
更新日期:2020-08-20 00:00:00
abstract::The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12946
更新日期:2020-08-14 00:00:00
abstract::Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12959
更新日期:2020-08-13 00:00:00
abstract::Substance use disorder is a complex disease created in part by maladaptive learning and memory mechanisms following repeated drug use. Exposure to drug-associated stimuli engages prefrontal cortex circuits, and dysfunction of the medial prefrontal cortex (mPFC) is thought to underlie drug-seeking behaviors. Growing ev...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12947
更新日期:2020-08-04 00:00:00
abstract::Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12802
更新日期:2020-07-01 00:00:00
abstract::The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking. We investigated the role of adult hippocampal neur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12778
更新日期:2020-07-01 00:00:00
abstract::Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12820
更新日期:2020-07-01 00:00:00
abstract::Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12815
更新日期:2020-07-01 00:00:00
abstract::Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12779
更新日期:2020-07-01 00:00:00
abstract::The World Health Organization estimates a 12-month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age-related functional decline. According to neuropathologi...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12746
更新日期:2020-05-01 00:00:00
abstract::The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim, male and female C57BL/6J mice (n = 60 per sex) were exposed to the drinking in the dark (DID) model for 4 weeks (DID-1 to DID-4). Dose-response effects of CBD on t...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12765
更新日期:2020-05-01 00:00:00
abstract::Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CU...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12762
更新日期:2020-05-01 00:00:00
abstract::Adolescent alcohol use is associated with increased risk for alcohol use disorders later in life; therefore, identifying biomarkers for initiation of heavy alcohol use, such as individual differences in the development of white-matter microstructure, may inform prevention strategies that improve public health. This pr...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12767
更新日期:2020-05-01 00:00:00
abstract::Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investig...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12912
更新日期:2020-04-23 00:00:00
abstract::Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12890
更新日期:2020-03-05 00:00:00
abstract::Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cogn...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12737
更新日期:2020-03-01 00:00:00
abstract::Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12740
更新日期:2020-03-01 00:00:00
abstract::Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12751
更新日期:2020-03-01 00:00:00
abstract::Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12706
更新日期:2020-03-01 00:00:00
abstract::Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor increasing vulnerability involves reduced expression of the serotonin transporter (5-HTT). Human s...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12722
更新日期:2020-01-01 00:00:00
abstract::Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12680
更新日期:2020-01-01 00:00:00
abstract::Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the bra...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12718
更新日期:2020-01-01 00:00:00
abstract::Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inabilit...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12684
更新日期:2020-01-01 00:00:00
abstract::We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12703
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or hi...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12702
更新日期:2020-01-01 00:00:00
abstract::Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12688
更新日期:2019-11-01 00:00:00
abstract::Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12677
更新日期:2019-09-01 00:00:00
abstract::The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are more likely to use alcohol to cope w...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12784
更新日期:2019-09-01 00:00:00
abstract::Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12663
更新日期:2019-09-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) regulates a variety of physiological processes, and several studies have explored the role of BDNF in addiction-related brain regions like the nucleus accumbens core (NAcore). We sought to understand the rapid effects of endogenous BDNF on cocaine seeking. Rats were trained to ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12638
更新日期:2019-09-01 00:00:00
abstract::Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12632
更新日期:2019-07-01 00:00:00
abstract::The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...
journal_title:Addiction biology
pub_type: 杂志文章,随机对照试验
doi:10.1111/adb.12611
更新日期:2019-05-01 00:00:00
abstract::Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impair...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12584
更新日期:2019-03-01 00:00:00