Abstract：
:Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2B protein expression in the hippocampal CA1 after morphine conditioned place preference (CPP) expression in rats. Interestingly, we also found that phosphorylation of SNAP25 at Ser187 (pSer187-SNAP25), a PKC-activated target, was significantly increased following morphine CPP expression. Blocking the pSer187-SNAP25 by intra-CA1 injection of an interfering peptide impaired morphine CPP expression and accompanied by the reduced ratio of GluN2B membrane/total in the CA1. In addition, intra-CA1 blockade of pSer187-SNAP25 did not affect natural learning and memory process as evidenced by intact sucrose-induced CPP expression and normal locomotor activity in rats. Therefore, our results reveal that enhanced pSer187-SNAP25 by PKC recruits GluN2B-NMDAR to the membrane surface in the hippocampal CA1 and mediates context-induced addiction memory retrieval. Our findings in this study fill in the missing link and provide better understanding of the molecular mechanisms involved in morphine-associated contextual memory retrieval.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Wang X,Liu Y,Jia M,Sun X,Wang N,Li Y,Cui Cdoi
10.1111/adb.12558subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1067-1078issue
5eissn
1355-6215issn
1369-1600journal_volume
23pub_type
杂志文章abstract：:The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that controls global protein synthesis, in part, by modulating translation initiation, a rate-limiting step for many mRNAs. Previous studies implicate mTOR in regulating stimulant-induced sensitization and antidepressive-like behavior in rodents, as...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2010.00311.x
更新日期：2012-03-01 00:00:00
abstract：:The genetic and environmental contributions to differences in response to ethanol have been examined widely using inbred strains, selected lines and genetically engineered (transgenic and 'knock-out') animals. In addition, recombinant inbred strains have been used to identify QTLs (chromosomal regions) associated with...
journal_title：Addiction biology
pub_type： 杂志文章,评审
doi：10.1080/13556210412331308985
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abstract：:Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin....
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2012.00479.x
更新日期：2013-01-01 00:00:00
abstract：:Ethanol oxidation to acetaldehyde and next to acetate is accompanied by free radical generation. Free radicals can affect cell integrity when antioxidant mechanisms are no longer able to cope with the free radical generation observed in ethanol intoxication. Natural antioxidants are particularly useful in such a situa...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210220139523
更新日期：2002-07-01 00:00:00
abstract：:In our society every second polytraumatized patient is a chronic alcoholic. A patient's alcohol-related history is often unavailable and laboratory markers are not sensitive or specific enough to detect alcohol-dependent patients who are at risk of developing alcohol withdrawal syndrome (AWS) during their post-traumat...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/1355621961000124726
更新日期：1996-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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abstract：:Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12632
更新日期：2019-07-01 00:00:00
abstract：:The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking. We investigated the role of adult hippocampal neur...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12778
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abstract：:Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12338
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2020-08-20 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1369-1600.2007.00082.x
更新日期：2008-03-01 00:00:00
abstract：:The rate of acetaldehyde metabolism was measured in aortic rings from rat strains genetically bred for high (UChB) and low (UChA) voluntary ethanol consumption. The results show that in aortic rings from naive UChB rats, acetaldehyde oxidation rates were significantly greater than the rates observed in aortic rings fr...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219971849
更新日期：1999-01-01 00:00:00
abstract：:We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12294
更新日期：2017-01-01 00:00:00
abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...
journal_title：Addiction biology
pub_type： 评论,杂志文章
doi：10.1111/adb.12265
更新日期：2017-01-01 00:00:00
abstract：:The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neur...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2007.00092.x
更新日期：2008-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2008.00145.x
更新日期：2009-07-01 00:00:00
abstract：:Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investig...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12912
更新日期：2020-04-23 00:00:00
abstract：:Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of comp...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12578
更新日期：2019-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章,评审
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journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
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更新日期：2012-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
abstract：:Erythroycte delta aminolevulinic acid dehydratase (ALAD) has been suggested as a marker for detecting recent alcohol intake. Unlike other markers, ALAD activity decreases after alcohol intake. Review of the literature suggests that the main interest in this marker is because it increases rapidly after withdrawal. The ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219772778
更新日期：1997-04-01 00:00:00
abstract：:Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
abstract：:Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their influence on cocaine-dependent behavioral and neuronal plasticity has not been explained. In this s...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
abstract：:Several studies have emphasized the role of learning in the development of rapid and chronic tolerances. Recently, it was shown that the NMDA antagonists MK-801(dizocilpine) and ketamine block the development of tolerance to ethanol in rats submitted to tilt-plane apparatus. The present study examines the generality o...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219872344
更新日期：1998-01-01 00:00:00
abstract：:Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
abstract：:Several studies show that substance dependence disorders are characterized by an enhanced processing of substance-related stimuli. The present study was designed to examine the association between craving levels and selective processing of drug cues in cocaine-dependent patients using event-related brain potentials (E...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2008.00100.x
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