Abstract:
:Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF1 and CRF2 receptor mRNA. Furthermore, the ascending NI relaxin-3 system is implicated in alcohol seeking in rats. Therefore, in alcohol-preferring rats, we examined the effect of bilateral injections into the NI of the CRF1 receptor antagonist, CP376395 or the CRF2 receptor antagonist, astressin-2B on yohimbine-induced reinstatement of alcohol seeking. Using quantitative PCR analysis of NI micropunches, we assessed the effects of chronic alcohol consumption on gene expression profiles for components of the relaxin-3 and CRF systems. Bilateral intra-NI injections of CP376395 (500 ng/0.25 µl) attenuated yohimbine-induced reinstatement of alcohol seeking. In contrast, intra-NI injections of astressin-2B (200 ng/0.25 µl) had no significant effect. In line with these data, CRF1 , but not CRF2 , receptor mRNA was upregulated in the NI following chronic ethanol intake. Relaxin family peptide 3 receptor mRNA was also increased in the NI following chronic ethanol. Our quantitative PCR analysis also identified CRF mRNA within the rat NI, and the existence of a newly identified population of CRF-containing neurons was subsequently confirmed by detection of CRF immunoreactivity in rat and mouse NI. These data suggest that NI neurons contribute to reinstatement of alcohol seeking, via an involvement of CRF1 signalling. Furthermore, chronic ethanol intake leads to neuroadaptive changes in CRF and relaxin-3 systems within rat NI.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Walker LC,Kastman HE,Koeleman JA,Smith CM,Perry CJ,Krstew EV,Gundlach AL,Lawrence AJdoi
10.1111/adb.12426subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1641-1654issue
6eissn
1355-6215issn
1369-1600journal_volume
22pub_type
杂志文章abstract::Transferrin (T f) and its carbohydrate-deficient isoform (CDT) were measured by radioimmunoassay in phosphate-buffered saline extracts of two informative areas of cerebral cortex tissue obtained at autopsy from alcoholics without other associated disease (n = 4); alcoholics with cirrhosis of the liver (n = 4) and agem...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219772633
更新日期:1997-07-01 00:00:00
abstract::Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspe...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/j.1369-1600.2008.00135.x
更新日期:2009-01-01 00:00:00
abstract::The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00145.x
更新日期:2009-07-01 00:00:00
abstract::Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12531
更新日期:2018-03-01 00:00:00
abstract::Identifying addicts with higher risk of relapse would provide the opportunity to implement individualized interventions and increase cessation success rates. Unfortunately, the ability to predict the long-term success of drug cessation treatments continues to elude researchers. We tested whether brain responses to emo...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00372.x
更新日期:2012-11-01 00:00:00
abstract::Cannabinoid type 1 (CB1) receptors control the motivational properties and reinforcing effects of nicotine. Indeed, peripheral administration of a CB1 receptor antagonist dramatically decreases both nicotine taking and seeking. However, the neural substrates through which the cannabinoid CB1 receptors regulate the vol...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00476.x
更新日期:2013-11-01 00:00:00
abstract::The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist such as an abused drug phencyclidine (PCP) causes the induction of heat shock protein HSP-70, a sensitive marker of neuronal injury, in the retrosplenial cortex of rat brain. The present study was undertaken to examine the role of a -amino-3- hydroxy-...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219772859
更新日期:1997-01-01 00:00:00
abstract::Betel quid chewing has been claimed to produce a sense of well-being, euphoria, warm sensation of the body, sweating, salivation, palpitation, heightened alertness and increased capacity to work. These effects suggest that betel quid chewing affects predominantly the central and autonomic nervous systems. Several stud...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1080/13556210120091473
更新日期:2002-01-01 00:00:00
abstract::Copy number variations (CNVs) can alter the DNA sequence in blocks ranging from kilobases to megabases, involving more total nucleotides than single nucleotide polymorphisms. Yet, its impact in humans is far from fully understood. In this study, we investigate the relationship of genome-wide CNVs with brain function e...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00393.x
更新日期:2013-05-01 00:00:00
abstract::Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12188
更新日期:2015-01-01 00:00:00
abstract::Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12820
更新日期:2020-07-01 00:00:00
abstract::The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12361
更新日期:2017-05-01 00:00:00
abstract::Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12632
更新日期:2019-07-01 00:00:00
abstract::Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12815
更新日期:2020-07-01 00:00:00
abstract::Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00488.x
更新日期:2014-05-01 00:00:00
abstract::Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide. These mushrooms represent a growing problem regarding hallucinogenic drug abuse. Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocy...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1080/1355621021000005937
更新日期:2002-10-01 00:00:00
abstract::The controversy over the relationship between heroin addiction and hepatocellular dysfunction was examined by assay of serum activities of aspartate and alanine aminotransferases, total protein, albumin and globulin in 48 chronic heroin smokers and 33 controls. Biliary secretion in the addicts was compared to controls...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621961000124826
更新日期:1996-01-01 00:00:00
abstract::Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12876
更新日期:2021-01-01 00:00:00
abstract::Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or preven...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12161
更新日期:2015-07-01 00:00:00
abstract::We demonstrated that the genotype of the variable number tandem repeats (VNTRs) in the linked polymorphic region (LPR) of the 5' promoter and in the intron 2 (Stin2) transcriptional regulatory domains of the serotonin transporter SLC6A4 gene determined its promoter interactions with transcription factors and co-activa...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00288.x
更新日期:2012-01-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12058
更新日期:2014-09-01 00:00:00
abstract::The Lewis (LEW) and Fischer 344 (F344) inbred rat strains are frequently used to study the role of genetic factors in vulnerability to drug addiction and relapse. Glutamate and γ-amino butyric acid (GABA) transmission are significantly altered after cocaine-induced reinstatement, although whether LEW and F344 rats dif...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00404.x
更新日期:2013-07-01 00:00:00
abstract::Alcohol exposure during fetal and early postnatal development can lead to an increased incidence of later life adult-onset diseases. Examples include central nervous system dysfunction, depression, anxiety, hyperactivity, and an inability to deal with stressful situations, increased infection and cancer. Direct effect...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12186
更新日期:2016-01-01 00:00:00
abstract::Voluntary oral ethanol consumption in rodents is generally limited by strong taste-aversion in these species. Historically, this has been overcome by combining ethanol with a sweetener, typically sucrose or saccharine, and then slowly 'fading' away the sweetener. While useful in most instances, this approach has not p...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00260.x
更新日期:2012-01-01 00:00:00
abstract::Abstract Twenty-eight Wistar rats treated orally with 20% ethanol solution, were divided into two groups: adult group (n = 19) and aged group (n = 9) consisting of animals aged 4 and 12 months, respectively, at the beginning of the treatment. Neurons from the basal nucleus region were counted and the percentage of cho...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/135562101200100571
更新日期:2002-01-01 00:00:00
abstract::Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2007.00067.x
更新日期:2007-06-01 00:00:00
abstract::The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking. We investigated the role of adult hippocampal neur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12778
更新日期:2020-07-01 00:00:00
abstract::Animal research supports a central role for corticotropin-releasing factor (CRF) in actions of ethanol on brain function. An examination of alcohol consumption in adolescents reported a significant genotype x environment (G x E) interaction involving rs1876831, a corticotropin-releasing hormone receptor 1 (CRHR1) poly...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2009.00181.x
更新日期:2010-01-01 00:00:00
abstract::Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12480
更新日期:2018-01-01 00:00:00
abstract::Converging epidemiological studies show that a life-threatening event increases the incidence of posttraumatic stress disorder (PTSD), which carries 30% to 50% comorbidity with substance use disorders (SUDs). Such comorbidity results in greater drug use and poorer treatment outcomes. There is overlap between the endur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12798
更新日期:2020-09-01 00:00:00