Frustrated expected reward induces differential transcriptional changes in the mouse brain.

abstract：:Substance use disorder is a complex disease created in part by maladaptive learning and memory mechanisms following repeated drug use. Exposure to drug-associated stimuli engages prefrontal cortex circuits, and dysfunction of the medial prefrontal cortex (mPFC) is thought to underlie drug-seeking behaviors. Growing ev...

journal_title：Addiction biology

authors： Jorgensen ET,Gonzalez AE,Harkness JH,Hegarty DM,Thakar A,Burchi DJ,Aadland JA,Aicher SA,Sorg BA,Brown TE

更新日期：2020-08-04 00:00:00

abstract：:The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...

journal_title：Addiction biology

authors： Navarrete F,Rubio G,Manzanares J

更新日期：2014-09-01 00:00:00

abstract：:The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist such as an abused drug phencyclidine (PCP) causes the induction of heat shock protein HSP-70, a sensitive marker of neuronal injury, in the retrosplenial cortex of rat brain. The present study was undertaken to examine the role of a -amino-3- hydroxy-...

journal_title：Addiction biology

authors： Narita N,Hashimoto K,Tomitaka S,Minabe Y,Yamazaki K

更新日期：1997-01-01 00:00:00

abstract：:Several studies have emphasized the role of learning in the development of rapid and chronic tolerances. Recently, it was shown that the NMDA antagonists MK-801(dizocilpine) and ketamine block the development of tolerance to ethanol in rats submitted to tilt-plane apparatus. The present study examines the generality o...

journal_title：Addiction biology

authors： Barreto PS,Lemos T,Morato GS

更新日期：1998-01-01 00:00:00

abstract：:This review article discusses the importance of identifying gene-environment interactions for understanding the etiology and course of alcohol use disorders and related conditions. A number of critical challenges are discussed, including the fact that there is no organizing typology for classifying different types of ...

journal_title：Addiction biology

authors： Sher KJ,Dick DM,Crabbe JC,Hutchison KE,O'Malley SS,Heath AC

更新日期：2010-04-01 00:00:00

abstract：:Ethyl glucuronide (EtG) is a promising new biological state marker of recent alcohol consumption that detects alcohol use reliably over a definite time period. Other currently available markers lack acceptable sensitivity and specificity. Our aim is to elucidate under naturalistic conditions the time course of EtG exc...

journal_title：Addiction biology

authors： Wurst FM,Seidl S,Ladewig D,Müller-Spahn F,Alt A

更新日期：2002-10-01 00:00:00

abstract：:The drive to eat is regulated by two compensatory brain pathways termed as homeostatic and hedonic. Hypothalamic orexinergic (ORX) neurons regulate metabolism, feeding and reward, thus controlling physiological and hedonic appetite. Circadian regulation of feeding, metabolism and rhythmic activity of ORX cells are dri...

journal_title：Addiction biology

authors： Feillet CA,Bainier C,Mateo M,Blancas-Velázquez A,Salaberry NL,Ripperger JA,Albrecht U,Mendoza J

更新日期：2017-03-01 00:00:00

abstract：:Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in the treatment of drug dependence and drug withdrawal. Oxytocin reduces methamphetamine self-administration, conditioned place preference and hyperactivity in rodents. However, it is unclear how oxytocin acts in the brain to prod...

journal_title：Addiction biology

authors： Carson DS,Hunt GE,Guastella AJ,Barber L,Cornish JL,Arnold JC,Boucher AA,McGregor IS

更新日期：2010-10-01 00:00:00

abstract：:We measured hippocampal volumes and cognitive functioning in crack-cocaine and crack-cocaine/alcoholdependent subjects (abstinent approximately 10-12 weeks) compared to age-matched controls. Cognitive function was evaluated using the computerized MicroCog Assessment of Cognitive Functioning (which includes tests of ex...

journal_title：Addiction biology

authors： DI Sclafani V,Truran DL,Bloomer C,Tolou-Shams M,Clark HW,Norman D,Hannauer D,Fein G

更新日期：1998-07-01 00:00:00

abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...

journal_title：Addiction biology

authors： Wang JQ,McGinty JF

更新日期：1999-04-01 00:00:00

abstract：:The technique of domiciliary rapid opiate detoxification (ROD) developed in Asturias since 1994 enables patients dependent on heroin and/or methadone (or other opiates) to start antagonist maintenance with a full dose of naltrexone (50 mg) and largely recover from the acute opiate withdrawal syndrome in a few hours at...

journal_title：Addiction biology

authors： Carreño JE,Bobes J,Brewer C,Alvarez CE,San Narciso GI,Bascarán MT,Sánchez del Río J

更新日期：2002-04-01 00:00:00

abstract：:The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...

journal_title：Addiction biology

authors： Wang YJ,Huang P,Blendy JA,Liu-Chen LY

更新日期：2014-05-01 00:00:00

abstract：:This study investigated the effects of chronic ethanol intake on hepatic haemodynamics and reticuloendothelial system function in the rat. Comparisons were also made with blood flow to pancreas, kidney, spleen, lung and skin. Male Wistar rats, approximately 0.15 kg initial body weight, were fed a diet containing 35% o...

journal_title：Addiction biology

authors： Preedy VR,Nott DM,Yates J,Venkatesan S,Jenkins SA,Peters TJ

更新日期：1997-10-01 00:00:00

abstract：:The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neur...

journal_title：Addiction biology

authors： Chu NN,Xia W,Yu P,Hu L,Zhang R,Cui CL

更新日期：2008-03-01 00:00:00

abstract：:We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 ...

journal_title：Addiction biology

authors： Reginsson GW,Ingason A,Euesden J,Bjornsdottir G,Olafsson S,Sigurdsson E,Oskarsson H,Tyrfingsson T,Runarsdottir V,Hansdottir I,Steinberg S,Stefansson H,Gudbjartsson DF,Thorgeirsson TE,Stefansson K

更新日期：2018-01-01 00:00:00

abstract：:Associations between nicotine in cigarettes and food consumption may alter the incentive value of food such that food cue-reactivity is exaggerated during abstinence from smoking. This effect may contribute to the weight gain associated with cessation of smoking. We examined the effects of nicotine (0.4 mg/kg base sub...

journal_title：Addiction biology

authors： Grimm JW,Ratliff C,North K,Barnes J,Collins S

更新日期：2012-05-01 00:00:00

abstract：:Erythroycte delta aminolevulinic acid dehydratase (ALAD) has been suggested as a marker for detecting recent alcohol intake. Unlike other markers, ALAD activity decreases after alcohol intake. Review of the literature suggests that the main interest in this marker is because it increases rapidly after withdrawal. The ...

journal_title：Addiction biology

authors： Aubin HJ,Laureaux C,Tilikete S,Gillet C,Lepetitcorps A,Nguyen T,Troupel S,Paille F,Barrucand D

更新日期：1997-04-01 00:00:00

abstract：:Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...

journal_title：Addiction biology

authors： Lawn W,Mithchener L,Freeman TP,Benattayallah A,Bisby JA,Wall MB,Dodds CM,Curran HV,Morgan CJA

更新日期：2020-07-01 00:00:00

abstract：:Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...

journal_title：Addiction biology

authors： Henry BL,Minassian A,Perry W

更新日期：2012-05-01 00:00:00

abstract：:Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhe...

journal_title：Addiction biology

authors： Driscoll CA,Lindell SG,Schwandt ML,Suomi SJ,Higley JD,Heilig M,Barr CS

更新日期：2017-11-01 00:00:00

abstract：:Nicotine dependence (ND) is a chronic disease with catastrophic effects on individual and public health. The glutamate receptor subunit gene, ionotropic N-methyl-d-aspartate 3A (GRIN3A), encodes a crucial subunit of N-methyl-d-aspartate receptors (NMDARs), which play an essential role in synaptic plasticity in the bra...

journal_title：Addiction biology

authors： Chen J,Liu Q,Fan R,Han H,Yang Z,Cui W,Song G,Li MD

更新日期：2020-01-01 00:00:00

abstract：:Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present ...

journal_title：Addiction biology

authors： Dijkstra BA,De Jong CA,Bluschke SM,Krabbe PF,van der Staak CP

更新日期：2007-06-01 00:00:00

abstract：:In keeping with its ability to control the mesoaccumbens dopamine (DA) pathway, the serotonin2C receptor (5-HT2C R) plays a key role in mediating the behavioral and neurochemical effects of drugs of abuse. Studies assessing the influence of 5-HT2C R agonists on cocaine-induced responses have suggested that 5-HT2C Rs c...

journal_title：Addiction biology

authors： Cathala A,Devroye C,Maitre M,Piazza PV,Abrous DN,Revest JM,Spampinato U

更新日期：2015-05-01 00:00:00

abstract：:Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or preven...

journal_title：Addiction biology

authors： Simon-O'Brien E,Alaux-Cantin S,Warnault V,Buttolo R,Naassila M,Vilpoux C

更新日期：2015-07-01 00:00:00

abstract：:Schizophrenia is a mental disorder characterized by a series of positive, negative or cognitive symptoms but with also the particularity of exhibiting a high rate of co-morbid use of drugs of abuse. While more than 80% of schizophrenics are smokers, the second most consumed drug is alcohol, with dramatic consequences ...

journal_title：Addiction biology

authors： Jeanblanc J,Balguerie K,Coune F,Legastelois R,Jeanblanc V,Naassila M

更新日期：2015-05-01 00:00:00

abstract：:Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...

journal_title：Addiction biology

authors： Vaquero L,Cámara E,Sampedro F,Pérez de Los Cobos J,Batlle F,Fabregas JM,Sales JA,Cervantes M,Ferrer X,Lazcano G,Rodríguez-Fornells A,Riba J

更新日期：2017-05-01 00:00:00

abstract：:Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...

journal_title：Addiction biology

authors： Mori T,Rahmadi M,Yoshizawa K,Itoh T,Shibasaki M,Suzuki T

更新日期：2014-05-01 00:00:00

abstract：:Although substantial research effort has focused on developing pharmacological treatments for cocaine abuse, no effective medications have been developed. Recent studies show that enzymes that metabolize cocaine in the periphery, forestalling its entry into the brain, can prevent cocaine toxicity and its behavioral ef...

journal_title：Addiction biology

authors： Schindler CW,Justinova Z,Lafleur D,Woods D,Roschke V,Hallak H,Sklair-Tavron L,Redhi GH,Yasar S,Bergman J,Goldberg SR

更新日期：2013-01-01 00:00:00

abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...

journal_title：Addiction biology

authors： Tam PG

更新日期：2017-01-01 00:00:00

abstract：:The Lewis (LEW) and Fischer 344 (F344) inbred rat strains are frequently used to study the role of genetic factors in vulnerability to drug addiction and relapse. Glutamate and γ-amino butyric acid (GABA) transmission are significantly altered after cocaine-induced reinstatement, although whether LEW and F344 rats dif...

journal_title：Addiction biology

authors： Miguéns M,Botreau F,Olías O,Del Olmo N,Coria SM,Higuera-Matas A,Ambrosio E

更新日期：2013-07-01 00:00:00