Modification of pharmacokinetic and abuse-related effects of cocaine by human-derived cocaine hydrolase in monkeys.

Abstract:

:Although substantial research effort has focused on developing pharmacological treatments for cocaine abuse, no effective medications have been developed. Recent studies show that enzymes that metabolize cocaine in the periphery, forestalling its entry into the brain, can prevent cocaine toxicity and its behavioral effects in rodents. Here we report on effects of one such enzyme (Albu-CocH) on the pharmacokinetic and behavioral effects of cocaine in squirrel monkeys. Albu-CocH was developed from successive mutations of human butyrylcholinesterase (BChE) and has 1000-fold greater catalytic activity against cocaine than naturally occurring BChE. Pharmacokinetic studies showed that Albu-CocH (5 mg/kg) had a half-life of 56.6 hours in squirrel monkeys. In these studies, plasma levels of cocaine following i.v. 1 mg/kg cocaine were reduced 2 hours after administration of Albu-CocH, whereas plasma levels of the cocaine metabolite ecgonine methyl ester were increased. These effects were still evident 72 hours following Albu-CocH administration. In behavioral experiments in monkeys, pre-treatment with 5 mg/kg Albu-CocH dramatically decreased self-administration of a reinforcing dose of i.v. cocaine (30 µg/kg/injection) for over 24 hours. Pre-treatment with 5 mg/kg Albu-CocH also attenuated the reinstatement of extinguished cocaine self-administration by an i.v. priming injection of cocaine (0.1 or 0.3 mg/kg) and, in separate studies, attenuated the discriminative-stimulus effects of cocaine. The ability of Albu-CocH to attenuate the abuse-related effects of cocaine in squirrel monkeys indicates that further investigation of BChE mutants as potential treatment for cocaine abuse and toxicity is warranted.

journal_name

Addict Biol

journal_title

Addiction biology

authors

Schindler CW,Justinova Z,Lafleur D,Woods D,Roschke V,Hallak H,Sklair-Tavron L,Redhi GH,Yasar S,Bergman J,Goldberg SR

doi

10.1111/j.1369-1600.2011.00424.x

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

30-9

issue

1

eissn

1355-6215

issn

1369-1600

journal_volume

18

pub_type

杂志文章
  • Interaction of mazindol with alcohol in mice.

    abstract::Combined anorectic-alcohol misuse is a prevalent problem in Brazil. In order to understand better the interactive effects of ethanol (EtOH) and mazindol (MZ), we examined the effects of EtOH (1.2 g/kg) and MZ (5.0 mg/kg) given alone or in combination, on mouse behaviour. The results indicate that EtOH plus MZ induces ...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1080/1355621961000124926

    authors: Gevaerd MS,Takahashi RN

    更新日期:1996-01-01 00:00:00

  • Role of peroxynitrite in methamphetamine-induced dopaminergic neurotoxicity and sensitization in mice.

    abstract::Abstract Methamphetamine (METH)-induced dopaminergic neurotoxicity is thought to be associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recently, we have reported that copper/zinc(CuZn)-superoxide dismutase transgenic mice are resistant to METH-induced neurotoxicity. In...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/j.1369-1600.2000.tb00200.x

    authors: Ali SF,Haung P,Itzhak Y

    更新日期:2000-07-01 00:00:00

  • The FAS Screen: a rapid screening tool for fetal alcohol syndrome.

    abstract::Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1080/13556219971542

    authors: Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

    更新日期:1999-07-01 00:00:00

  • Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking.

    abstract::The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/j.1369-1600.2011.00314.x

    authors: Gamaleddin I,Wertheim C,Zhu AZ,Coen KM,Vemuri K,Makryannis A,Goldberg SR,Le Foll B

    更新日期:2012-01-01 00:00:00

  • Pulling habits out of rats: adenosine 2A receptor antagonism in dorsomedial striatum rescues meth-amphetamine-induced deficits in goal-directed action.

    abstract::Addiction is characterized by a persistent loss of behavioral control resulting in insensitivity to negative feedback and abnormal decision-making. Here, we investigated the influence of methamphetamine (METH)-paired contextual cues on decision-making in rats. Choice between goal-directed actions was sensitive to outc...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12316

    authors: Furlong TM,Supit AS,Corbit LH,Killcross S,Balleine BW

    更新日期:2017-01-01 00:00:00

  • Glutamatergic input from the insula to the ventral bed nucleus of the stria terminalis controls reward-related behavior.

    abstract::Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug-predictive cues and is thought to be a critical substrate for drug craving, but the downstream neural circuit effectors of the IC that med...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12961

    authors: Girven KS,Aroni S,Navarrete J,Marino RAM,McKeon PN,Cheer JF,Sparta DR

    更新日期:2020-08-20 00:00:00

  • HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex.

    abstract::Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cogn...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12737

    authors: González B,Bernardi A,Torres OV,Jayanthi S,Gomez N,Sosa MH,García-Rill E,Urbano FJ,Cadet JL,Bisagno V

    更新日期:2020-03-01 00:00:00

  • Neural correlates of tobacco cue reactivity predict duration to lapse and continuous abstinence in smoking cessation treatment.

    abstract::It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic r...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12549

    authors: Owens MM,MacKillop J,Gray JC,Beach SRH,Stein MD,Niaura RS,Sweet LH

    更新日期:2018-09-01 00:00:00

  • Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme.

    abstract::Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty acid amide hydrolase (FAAH) gene (rs324420) have been implicated in CU...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12762

    authors: Hindocha C,Freeman TP,Schafer G,Gardner C,Bloomfield MAP,Bramon E,Morgan CJA,Curran HV

    更新日期:2020-05-01 00:00:00

  • Effect of methamphetamine dependence on heart rate variability.

    abstract::Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/j.1369-1600.2010.00270.x

    authors: Henry BL,Minassian A,Perry W

    更新日期:2012-05-01 00:00:00

  • Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder.

    abstract::The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12247

    authors: Zhang JT,Yao YW,Li CS,Zang YF,Shen ZJ,Liu L,Wang LJ,Liu B,Fang XY

    更新日期:2016-05-01 00:00:00

  • Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats.

    abstract::The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/j.1369-1600.2010.00299.x

    authors: Vinod KY,Maccioni P,Garcia-Gutierrez MS,Femenia T,Xie S,Carai MA,Manzanares J,Cooper TB,Hungund BL,Colombo G

    更新日期:2012-01-01 00:00:00

  • Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys.

    abstract::Ketamine, a non-competitive N-methyl-D-aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when ...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12004

    authors: Sun L,Li Q,Li Q,Zhang Y,Liu D,Jiang H,Pan F,Yew DT

    更新日期:2014-03-01 00:00:00

  • Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior.

    abstract::Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and the cystine-glutamate exchange protein xCT within the nucleus accumbens core (NAcore). N-acetylcysteine (NAC) has been shown to restore these proteins in a rodent model of drug addiction and relapse. How...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12797

    authors: Namba MD,Kupchik YM,Spencer SM,Garcia-Keller C,Goenaga JG,Powell GL,Vicino IA,Hogue IB,Gipson CD

    更新日期:2020-09-01 00:00:00

  • Risk factors for alcoholic liver disease.

    abstract::Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/j.1369-1600.2000.tb00190.x

    authors: Bellentani S,Saccoccio G,Masutti F,Giacca M,Miglioli L,Monzoni A,Tiribelli C

    更新日期:2000-07-01 00:00:00

  • Dysfunctional approach behavior triggered by alcohol-unrelated Pavlovian cues predicts long-term relapse in alcohol dependence.

    abstract::We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12703

    authors: Sommer C,Birkenstock J,Garbusow M,Obst E,Schad DJ,Bernhardt N,Huys QM,Wurst FM,Weinmann W,Heinz A,Smolka MN,Zimmermann US

    更新日期:2020-01-01 00:00:00

  • The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice.

    abstract::Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12663

    authors: Kim M,Custodio RJ,Botanas CJ,de la Peña JB,Sayson LV,Abiero A,Ryoo ZY,Cheong JH,Kim HJ

    更新日期:2019-09-01 00:00:00

  • Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain.

    abstract::The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are more likely to use alcohol to cope w...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12784

    authors: Bilbao A,Leixner S,Wei S,Cantacorps L,Valverde O,Spanagel R

    更新日期:2019-09-01 00:00:00

  • Effects of naltrexone plus topiramate on ethanol self-administration and tyrosine hydroxylase gene expression changes.

    abstract::The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12058

    authors: Navarrete F,Rubio G,Manzanares J

    更新日期:2014-09-01 00:00:00

  • NMDA-receptor antagonists block the development of rapid tolerance to ethanol in mice.

    abstract::Several studies have emphasized the role of learning in the development of rapid and chronic tolerances. Recently, it was shown that the NMDA antagonists MK-801(dizocilpine) and ketamine block the development of tolerance to ethanol in rats submitted to tilt-plane apparatus. The present study examines the generality o...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1080/13556219872344

    authors: Barreto PS,Lemos T,Morato GS

    更新日期:1998-01-01 00:00:00

  • The feasibility of an in-scanner smoking lapse paradigm to examine the neural correlates of lapses.

    abstract::Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.13001

    authors: Lydon-Staley DM,MacLean RR,Falk EB,Bassett DS,Wilson SJ

    更新日期:2021-01-28 00:00:00

  • Working memory and salivary brain-derived neurotrophic factor as developmental predictors of cocaine seeking in male and female rats.

    abstract::Poor working memory is linked to future risk-taking behaviors. Lifelong risk of habitual drug use is highest in individuals who initiate use in early adolescence. We sought to determine in rats whether juvenile traits, specifically poor working memory and low salivary brain-derived neurotrophic factor (BDNF), are rela...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12535

    authors: Jordan CJ,Andersen SL

    更新日期:2018-05-01 00:00:00

  • Effects of chronic inhalation of volatile solvents, malnutrition and their interaction on seizures induced by pentylenetetrazole in rats.

    abstract::Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1080/13556219871994

    authors: Palencia G,Calvillo M,Benita A,Sotelo J

    更新日期:1998-10-01 00:00:00

  • Social defeat in adolescent mice increases vulnerability to alcohol consumption.

    abstract::This study employs an oral operant conditioning paradigm to evaluate the effects of repeated social defeat during adolescence on the reinforcing and motivational actions of ethanol in adult OF1 mice. Social interaction, emotional and cognitive behavioral aspects were also analyzed, and real-time polymerase chain react...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12184

    authors: Rodriguez-Arias M,Navarrete F,Blanco-Gandia MC,Arenas MC,Bartoll-Andrés A,Aguilar MA,Rubio G,Miñarro J,Manzanares J

    更新日期:2016-01-01 00:00:00

  • Allelic association of a dopamine transporter gene polymorphism with antisocial behaviour in heroin-dependent patients.

    abstract::Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1080/13556210500223769

    authors: Gerra G,Garofano L,Pellegrini C,Bosari S,Zaimovic A,Moi G,Avanzini P,Talarico E,Gardini F,Donnini C

    更新日期:2005-09-01 00:00:00

  • Chronic viral hepatitis is a significant contributor to the immunosenescent phenotype of parenteral drug addiction.

    abstract::Intravenous drug addiction is known to be associated with an inordinate morbidity and mortality. As our previous report had identified an immune phenotype consistent with accelerated ageing, we wished to investigate how much of this change may have been related to chronic viral hepatitis. A total of 12 409 clinical pa...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/j.1369-1600.2008.00123.x

    authors: Reece AS

    更新日期:2009-04-01 00:00:00

  • Does naltrexone affect craving in abstinent opioid-dependent patients?

    abstract::Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present ...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/j.1369-1600.2007.00067.x

    authors: Dijkstra BA,De Jong CA,Bluschke SM,Krabbe PF,van der Staak CP

    更新日期:2007-06-01 00:00:00

  • Oxidant-antioxidant profiles of platelet rich plasma in smokers.

    abstract::Cigarette smoke is a major risk factor for both coronary heart disease and peripheral vascular disease and has been reported to contain many oxidizing agents that lead to generation of free radicals. In this study, we investigated the levels of lipid peroxides (LPO) and antioxidant vitamins (C and E), total thiol cont...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1080/13556210020077046

    authors: Gökkusu C,Ademoglu E,Tamer S,Alkan G

    更新日期:2001-09-01 00:00:00

  • Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene.

    abstract::Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/j.1369-1600.2012.00507.x

    authors: Wetherill RR,Jagannathan K,Lohoff FW,Ehrman R,O'Brien CP,Childress AR,Franklin TR

    更新日期:2014-03-01 00:00:00

  • Frustrated expected reward induces differential transcriptional changes in the mouse brain.

    abstract::Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...

    journal_title:Addiction biology

    pub_type: 杂志文章

    doi:10.1111/adb.12188

    authors: Martín-García E,Fernández-Castillo N,Burokas A,Gutiérrez-Cuesta J,Sánchez-Mora C,Casas M,Ribasés M,Cormand B,Maldonado R

    更新日期:2015-01-01 00:00:00