Male germline transmits fetal alcohol epigenetic marks for multiple generations: a review.

abstract：:Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...

journal_title：Addiction biology

authors： Rathitharan G,Truong J,Tong J,McCluskey T,Meyer JH,Mizrahi R,Warsh J,Rusjan P,Kennedy JL,Houle S,Kish SJ,Boileau I

更新日期：2021-01-01 00:00:00

abstract：:The aim of this study was to profile and compare blood naltrexone and 6-beta-naltrexol levels with time following treatment with two sustained-release naltrexone preparations produced by GoMedical Industries, Australia at a community heroin treatment clinic in Perth, Western Australia. A sample of 10 patients who each...

journal_title：Addiction biology

authors： Hulse GK,Arnold-Reed DE,O'Neil G,Chan CT,Hansson R,O'Neil P

更新日期：2004-03-01 00:00:00

abstract：:Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be involved in the pathophysiology of several disorders related to smoking and may be relevant for the pathophysiology of nico...

journal_title：Addiction biology

authors： Cohrs S,Rodenbeck A,Riemann D,Szagun B,Jaehne A,Brinkmeyer J,Gründer G,Wienker T,Diaz-Lacava A,Mobascher A,Dahmen N,Thuerauf N,Kornhuber J,Kiefer F,Gallinat J,Wagner M,Kunz D,Grittner U,Winterer G

更新日期：2014-05-01 00:00:00

abstract：:Chronic exposure to alcohol and other drugs of abuse has been associated with deleterious consequences, including functional connectivity deficits within neural networks associated with executive control. Altered functional connectivity within the executive control network (ECN) might underlie the progressive inabilit...

journal_title：Addiction biology

authors： Hagerty SL,YorkWilliams SL,Bidwell LC,Weiland BJ,Sabbineni A,Blaine SK,Bryan AD,Hutchison KE

更新日期：2020-01-01 00:00:00

abstract：:Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...

journal_title：Addiction biology

authors： Dunn KE,Weerts EM,Huhn AS,Schroeder JR,Tompkins DA,Bigelow GE,Strain EC

更新日期：2020-01-01 00:00:00

abstract：:Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...

journal_title：Addiction biology

authors： Vaquero L,Cámara E,Sampedro F,Pérez de Los Cobos J,Batlle F,Fabregas JM,Sales JA,Cervantes M,Ferrer X,Lazcano G,Rodríguez-Fornells A,Riba J

更新日期：2017-05-01 00:00:00

abstract：:Several studies show that substance dependence disorders are characterized by an enhanced processing of substance-related stimuli. The present study was designed to examine the association between craving levels and selective processing of drug cues in cocaine-dependent patients using event-related brain potentials (E...

journal_title：Addiction biology

authors： Franken IH,Dietvorst RC,Hesselmans M,Franzek EJ,van de Wetering BJ,Van Strien JW

更新日期：2008-09-01 00:00:00

abstract：:α-Synuclein has recently been implicated in the pathophysiology of alcohol abuse due to its role in dopaminergic neurotransmission. In these studies, genetic variability in the α-synuclein gene influences its expression which may contribute to susceptibility to chronic alcohol abuse. Real-time PCR was used to quantify...

journal_title：Addiction biology

authors： Janeczek P,MacKay RK,Lea RA,Dodd PR,Lewohl JM

更新日期：2014-05-01 00:00:00

abstract：:Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...

journal_title：Addiction biology

authors： Pavon FJ,Serrano A,Sidhpura N,Polis I,Stouffer D,de Fonseca FR,Cravatt BF,Martin-Fardon R,Parsons LH

更新日期：2018-03-01 00:00:00

abstract：:Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...

journal_title：Addiction biology

authors： de Miguel E,Vekovischeva O,Kuokkanen K,Vesajoki M,Paasikoski N,Kaskinoro J,Myllymäki M,Lainiola M,Janhunen SK,Hyytiä P,Linden AM,Korpi ER

更新日期：2019-11-01 00:00:00

abstract：:Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of comp...

journal_title：Addiction biology

authors： Brick LA,Keller MC,Knopik VS,McGeary JE,Palmer RHC

更新日期：2019-01-01 00:00:00

abstract：:Previous studies on acetaldehyde dehydrogenase 2 (ALDH2) focused on drinking behavior or alcoholism because the ALDH2*2 allele protects against the risk of developing alcoholism. The mechanism provides that the ALDH2 gene's protective effect is also involved in dopamine metabolism. The interaction of the ALDH2 gene wi...

journal_title：Addiction biology

authors： Lu RB,Lee JF,Huang SY,Lee SY,Chang YH,Kuo PH,Chen SL,Chen SH,Chu CH,Lin WW,Wu PL,Ko HC

更新日期：2012-09-01 00:00:00

abstract：:Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila ...

journal_title：Addiction biology

authors： Schmitt RE,Messick MR,Shell BC,Dunbar EK,Fang HF,Shelton KL,Venton BJ,Pletcher SD,Grotewiel M

更新日期：2020-07-01 00:00:00

abstract：:Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and funct...

journal_title：Addiction biology

authors： Kaarre O,Kallioniemi E,Könönen M,Tolmunen T,Kekkonen V,Kivimäki P,Heikkinen N,Ferreri F,Laukkanen E,Määttä S

更新日期：2018-01-01 00:00:00

abstract：:Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2...

journal_title：Addiction biology

authors： Wang X,Liu Y,Jia M,Sun X,Wang N,Li Y,Cui C

更新日期：2018-09-01 00:00:00

abstract：:Based on the knowledge that alcohol misuse causes a multitude of diseases and increased mortality, this systematic review examines whether a reduction of the individual alcohol consumption can contribute to a minimization of health risks within a harm reduction approach. In fact, the reviewed 63 studies indicate that ...

journal_title：Addiction biology

authors： Charlet K,Heinz A

更新日期：2017-09-01 00:00:00

abstract：:Betel quid chewing has been claimed to produce a sense of well-being, euphoria, warm sensation of the body, sweating, salivation, palpitation, heightened alertness and increased capacity to work. These effects suggest that betel quid chewing affects predominantly the central and autonomic nervous systems. Several stud...

journal_title：Addiction biology

authors： Chu NS

更新日期：2002-01-01 00:00:00

abstract：:In our society every second polytraumatized patient is a chronic alcoholic. A patient's alcohol-related history is often unavailable and laboratory markers are not sensitive or specific enough to detect alcohol-dependent patients who are at risk of developing alcohol withdrawal syndrome (AWS) during their post-traumat...

journal_title：Addiction biology

authors： Spies CD,Rommelspacher H,Winkler T,Müller C,Brummer G,Funk T,Berger G,Fell M,Blum S,Specht M,Hannemann L,Schaffartzik W

更新日期：1996-01-01 00:00:00

abstract：:The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...

journal_title：Addiction biology

authors： McLachlan-Troup N,Taylor GW,Trathen BC

更新日期：2001-07-01 00:00:00

abstract：:Copy number variations (CNVs) can alter the DNA sequence in blocks ranging from kilobases to megabases, involving more total nucleotides than single nucleotide polymorphisms. Yet, its impact in humans is far from fully understood. In this study, we investigate the relationship of genome-wide CNVs with brain function e...

journal_title：Addiction biology

authors： Liu J,Calhoun VD,Chen J,Claus ED,Hutchison KE

更新日期：2013-05-01 00:00:00

abstract：:We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a...

journal_title：Addiction biology

authors： Sommer C,Birkenstock J,Garbusow M,Obst E,Schad DJ,Bernhardt N,Huys QM,Wurst FM,Weinmann W,Heinz A,Smolka MN,Zimmermann US

更新日期：2020-01-01 00:00:00

abstract：:The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking. We investigated the role of adult hippocampal neur...

journal_title：Addiction biology

authors： Luján MÁ,Cantacorps L,Valverde O

更新日期：2020-07-01 00:00:00

abstract：:The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consum...

journal_title：Addiction biology

authors： Suchankova P,Nilsson S,von der Pahlen B,Santtila P,Sandnabba K,Johansson A,Jern P,Engel JA,Jerlhag E

更新日期：2016-03-01 00:00:00

abstract：:Associations between nicotine in cigarettes and food consumption may alter the incentive value of food such that food cue-reactivity is exaggerated during abstinence from smoking. This effect may contribute to the weight gain associated with cessation of smoking. We examined the effects of nicotine (0.4 mg/kg base sub...

journal_title：Addiction biology

authors： Grimm JW,Ratliff C,North K,Barnes J,Collins S

更新日期：2012-05-01 00:00:00

abstract：:The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...

journal_title：Addiction biology

authors： Wolff CB,Peters TJ,Keating J,Gardner WN

更新日期：1999-04-01 00:00:00

abstract：:Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...

journal_title：Addiction biology

authors： Martín-García E,Fernández-Castillo N,Burokas A,Gutiérrez-Cuesta J,Sánchez-Mora C,Casas M,Ribasés M,Cormand B,Maldonado R

更新日期：2015-01-01 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:The rate of acetaldehyde metabolism was measured in aortic rings from rat strains genetically bred for high (UChB) and low (UChA) voluntary ethanol consumption. The results show that in aortic rings from naive UChB rats, acetaldehyde oxidation rates were significantly greater than the rates observed in aortic rings fr...

journal_title：Addiction biology

authors： Quintanilla ME,Tampier L

更新日期：1999-01-01 00:00:00

abstract：:Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...

journal_title：Addiction biology

authors： Palencia G,Calvillo M,Benita A,Sotelo J

更新日期：1998-10-01 00:00:00

abstract：:Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug...

journal_title：Addiction biology

authors： Roura-Martínez D,Ucha M,Orihuel J,Ballesteros-Yáñez I,Castillo CA,Marcos A,Ambrosio E,Higuera-Matas A

更新日期：2020-03-01 00:00:00