Abstract:
:Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of animals, respectively. Animals with high titres of AbM had much weaker immune response to a thymus-dependent antigen (sheep red blood cells). In humans chronic opiate intoxication was accompanied by significant reduction of functional activity of T-lymphocytes, which was especially dramatic in addicts with high levels of antibodies to morphine: high incidence of infection was obvious in the latter group. Results suggest that high levels of antibodies to morphine serve as indicators, not only of chronic morphine intoxication, but of impaired immune reactivity, especially involving T-cell functional activity.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Gamaleya N,Tronnikov S,Ulyanova L,Klimova S,Dmitrieva Idoi
10.1080/1355621961000125046subject
Has Abstractpub_date
1996-01-01 00:00:00pages
437-45issue
4eissn
1355-6215issn
1369-1600pii
MBXKWN6D33MN6JUWjournal_volume
1pub_type
杂志文章abstract::Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12740
更新日期:2020-03-01 00:00:00
abstract::Through incentive learning, the emotional experience of a reward in a relevant need state (e.g. hunger for food) sets the incentive value that guides the performance of actions that earn that reward when the need state is encountered again. Opiate withdrawal has been proposed as a need state in which, through experien...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12172
更新日期:2016-03-01 00:00:00
abstract::Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dep...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12523
更新日期:2018-03-01 00:00:00
abstract::The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00484.x
更新日期:2014-05-01 00:00:00
abstract::Withdrawal of opioid drugs leads to a cluster of unpleasant symptoms in dependent subjects. These symptoms are stimulatory in nature and oppose the acute, inhibitory effects of opiates. The conventional theory that explains the opioid withdrawal syndrome assumes that chronic usage of opioid drugs activates compensator...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2009.00164.x
更新日期:2009-09-01 00:00:00
abstract::Substance use disorder is a complex disease created in part by maladaptive learning and memory mechanisms following repeated drug use. Exposure to drug-associated stimuli engages prefrontal cortex circuits, and dysfunction of the medial prefrontal cortex (mPFC) is thought to underlie drug-seeking behaviors. Growing ev...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12947
更新日期:2020-08-04 00:00:00
abstract::The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971740
更新日期:1999-04-01 00:00:00
abstract::The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00314.x
更新日期:2012-01-01 00:00:00
abstract::Alcohol exposure during fetal and early postnatal development can lead to an increased incidence of later life adult-onset diseases. Examples include central nervous system dysfunction, depression, anxiety, hyperactivity, and an inability to deal with stressful situations, increased infection and cancer. Direct effect...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12186
更新日期:2016-01-01 00:00:00
abstract::The controversy over the relationship between heroin addiction and hepatocellular dysfunction was examined by assay of serum activities of aspartate and alanine aminotransferases, total protein, albumin and globulin in 48 chronic heroin smokers and 33 controls. Biliary secretion in the addicts was compared to controls...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621961000124826
更新日期:1996-01-01 00:00:00
abstract::Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00443.x
更新日期:2014-01-01 00:00:00
abstract::Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12890
更新日期:2020-03-05 00:00:00
abstract::Hangover refers to the cluster of physiological and behavioral symptoms that occur following the end of a drinking episode. While hangover has been studied after the typical oral consumption of alcohol, the occurrence of hangover following intravenous (IV) alcohol administration in human laboratory studies has not bee...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12469
更新日期:2018-01-01 00:00:00
abstract::Chemical compounds that target dopamine (DA) D1 or D3 receptors have shown promise as potential interventions in animal models of cue-induced relapse. However, undesirable side effects or pharmacodynamic profiles have limited the advancement of new compounds in preclinical studies when administered as independent trea...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12988
更新日期:2021-01-25 00:00:00
abstract::Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-depe...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12234
更新日期:2016-05-01 00:00:00
abstract::Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subj...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12246
更新日期:2016-05-01 00:00:00
abstract::Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug-predictive cues and is thought to be a critical substrate for drug craving, but the downstream neural circuit effectors of the IC that med...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12961
更新日期:2020-08-20 00:00:00
abstract::The Lewis (LEW) and Fischer 344 (F344) inbred rat strains are frequently used to study the role of genetic factors in vulnerability to drug addiction and relapse. Glutamate and γ-amino butyric acid (GABA) transmission are significantly altered after cocaine-induced reinstatement, although whether LEW and F344 rats dif...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00404.x
更新日期:2013-07-01 00:00:00
abstract::Combined anorectic-alcohol misuse is a prevalent problem in Brazil. In order to understand better the interactive effects of ethanol (EtOH) and mazindol (MZ), we examined the effects of EtOH (1.2 g/kg) and MZ (5.0 mg/kg) given alone or in combination, on mouse behaviour. The results indicate that EtOH plus MZ induces ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621961000124926
更新日期:1996-01-01 00:00:00
abstract::The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210120056553
更新日期:2001-07-01 00:00:00
abstract::The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00145.x
更新日期:2009-07-01 00:00:00
abstract::Several studies show that substance dependence disorders are characterized by an enhanced processing of substance-related stimuli. The present study was designed to examine the association between craving levels and selective processing of drug cues in cocaine-dependent patients using event-related brain potentials (E...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00100.x
更新日期:2008-09-01 00:00:00
abstract::Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhe...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12428
更新日期:2017-11-01 00:00:00
abstract::The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210071289
更新日期:2000-01-01 00:00:00
abstract::The neural and genetic factors underlying chronic tolerance to alcohol are currently unclear. The GluN2A N-methyl-D-aspartate receptors (NMDAR) subunit and the NMDAR-anchoring protein PSD-95 mediate acute alcohol intoxication and represent putative mechanisms mediating tolerance. We found that chronic intermittent eth...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12110
更新日期:2015-03-01 00:00:00
abstract::Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210412331292578
更新日期:2004-09-01 00:00:00
abstract::The total concentration of THC has been monitored in cannabis preparations sold in Dutch coffee shops since 1999. This annual monitoring was issued by the Ministry of Health after reports of increased potency. The level of the main psychoactive compound, Delta9-tetrahydrocannabinol (THC), is measured in marijuana and ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210500123217
更新日期:2005-06-01 00:00:00
abstract::Early relapse is common after opiate withdrawal and deprives addicts of important opportunities to develop new, opiate-free cognitive-behavioural habits. The oral opiate antagonist naltrexone (NTX) significantly reduces relapse only when rigorously supervised and/or probation-linked. Simple but effective NTX implants,...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621031000117446
更新日期:2003-06-01 00:00:00
abstract::The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...
journal_title:Addiction biology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1369-1600.2009.00197.x
更新日期:2011-01-01 00:00:00
abstract::Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00507.x
更新日期:2014-03-01 00:00:00