Abstract：
:The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = 15) to a 14-day oxazepam/19-day carbamazepine regime (n = 12) in an open-labelled 21-day inpatient detoxification treatment was compared. Twenty-seven men and women dependent on opioids and misusing other drugs admitted to a detoxification unit were included in this protocol. Eighteen of 27 patients (67%) completed the study. Four non-completers (27%) received buprenorphine/carbamazepine (four of 15) and five non-completers (42%) were treated with oxazepam/carbamzepine (five of 12), but the difference in the dropout rate between the two treatment strategies was not significant.The buprenorphine/carbamazepine regime provided significantly more effective relief of withdrawal symptoms during the first week of treatment. No severe side effects occurred during treatment in both groups. The present study supports the hypothesis that buprenorphine/carbamazepine is more effective than oxazepam/carbamazepine in rapid opioid detoxification in patients with additional multiple drug misuse and both regimens were safe with no unexpected side effects.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Schneider U,Paetzold W,Eronat V,Huber TJ,Seifert J,Wiese B,Emrich HMdoi
10.1080/13556210071289subject
Has Abstractpub_date
2000-01-01 00:00:00pages
65-9issue
1eissn
1355-6215issn
1369-1600pii
ADB65journal_volume
5pub_type
杂志文章abstract：:The genetic and environmental contributions to differences in response to ethanol have been examined widely using inbred strains, selected lines and genetically engineered (transgenic and 'knock-out') animals. In addition, recombinant inbred strains have been used to identify QTLs (chromosomal regions) associated with...
journal_title：Addiction biology
pub_type： 杂志文章,评审
doi：10.1080/13556210412331308985
更新日期：2005-03-01 00:00:00
abstract：:Several studies have emphasized the role of learning in the development of rapid and chronic tolerances. Recently, it was shown that the NMDA antagonists MK-801(dizocilpine) and ketamine block the development of tolerance to ethanol in rats submitted to tilt-plane apparatus. The present study examines the generality o...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219872344
更新日期：1998-01-01 00:00:00
abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219971641
更新日期：1999-04-01 00:00:00
abstract：:Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00367.x
更新日期：2012-09-01 00:00:00
abstract：:The Lewis (LEW) and Fischer 344 (F344) inbred rat strains are frequently used to study the role of genetic factors in vulnerability to drug addiction and relapse. Glutamate and γ-amino butyric acid (GABA) transmission are significantly altered after cocaine-induced reinstatement, although whether LEW and F344 rats dif...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00404.x
更新日期：2013-07-01 00:00:00
abstract：:Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational u...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12038
更新日期：2013-09-01 00:00:00
abstract：:Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210500223769
更新日期：2005-09-01 00:00:00
abstract：:Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2012.00443.x
更新日期：2014-01-01 00:00:00
abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...
journal_title：Addiction biology
pub_type： 评论,杂志文章
doi：10.1111/adb.12265
更新日期：2017-01-01 00:00:00
abstract：:Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219971407
更新日期：1999-10-01 00:00:00
abstract：:Schizophrenia is a mental disorder characterized by a series of positive, negative or cognitive symptoms but with also the particularity of exhibiting a high rate of co-morbid use of drugs of abuse. While more than 80% of schizophrenics are smokers, the second most consumed drug is alcohol, with dramatic consequences ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12146
更新日期：2015-05-01 00:00:00
abstract：:The World Health Organization estimates a 12-month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age-related functional decline. According to neuropathologi...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12746
更新日期：2020-05-01 00:00:00
abstract：:Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.13001
更新日期：2021-01-28 00:00:00
abstract：:The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12247
更新日期：2016-05-01 00:00:00
abstract：:The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12058
更新日期：2014-09-01 00:00:00
abstract：:The class I hepatic alcohol dehydrogenases (ADHs) are primarily responsible for ethanol metabolism in humans. Genetic polymorphism at the ADH2 locus results in the inheritance of isozymes of strikingly different catalytic properties. In European and Caucasian American populations, β1, which is encoded by ADH2(1) , is ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219872218
更新日期：1998-04-01 00:00:00
abstract：:Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-depe...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12234
更新日期：2016-05-01 00:00:00
abstract：:Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol dependence syndrome (ADS) in East Asian populations. Recently, attention has focused on the role of these SNPs in determining ADS risk in European populations. To ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12141
更新日期：2015-05-01 00:00:00
abstract：:We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12703
更新日期：2020-01-01 00:00:00
abstract：:Ethanol oxidation to acetaldehyde and next to acetate is accompanied by free radical generation. Free radicals can affect cell integrity when antioxidant mechanisms are no longer able to cope with the free radical generation observed in ethanol intoxication. Natural antioxidants are particularly useful in such a situa...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210220139523
更新日期：2002-07-01 00:00:00
abstract：:Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219871994
更新日期：1998-10-01 00:00:00
abstract：:One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice. C57BL/6J mice were trained in operant conditioning maintain...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00423.x
更新日期：2012-07-01 00:00:00
abstract：:Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cogn...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12737
更新日期：2020-03-01 00:00:00
abstract：:Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12688
更新日期：2019-11-01 00:00:00
abstract：:The total concentration of THC has been monitored in cannabis preparations sold in Dutch coffee shops since 1999. This annual monitoring was issued by the Ministry of Health after reports of increased potency. The level of the main psychoactive compound, Delta9-tetrahydrocannabinol (THC), is measured in marijuana and ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210500123217
更新日期：2005-06-01 00:00:00
abstract：:Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2012.00507.x
更新日期：2014-03-01 00:00:00
abstract：:Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12558
更新日期：2018-09-01 00:00:00
abstract：:The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12946
更新日期：2020-08-14 00:00:00
abstract：:Nicotine withdrawal is associated with subtle working memory deficits that predict subsequent relapse. We examined the neural substrates underlying these processes in treatment-seeking smokers, and explored the moderating influence of age on abstinence-induced alterations in brain activity and performance. Sixty-three...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12051
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or hi...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12702
更新日期：2020-01-01 00:00:00
