Abstract:
:The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its association with Internet gaming characteristics in 74 young adults with Internet gaming disorder (IGD) and 41 age- and gender-matched healthy control subjects (HCs). In comparison with HCs, IGD subjects (IGDs) exhibited enhanced rsFC between the anterior insula and a network of regions including anterior cingulate cortex (ACC), putamen, angular gyrus, and precuneous, which are involved in salience, craving, self-monitoring, and attention. IGDs also demonstrated significantly stronger rsFC between the posterior insula and postcentral gyrus, precentral gyrus, supplemental motor area, and superior temporal gyrus (STG), which are involved in interoception, movement control, and auditory processing. Furthermore, IGD severity was positively associated with connectivity between the anterior insula and angular gyrus, and STG, and with connectivity between the posterior insula and STG. Duration of Internet gaming was positively associated with connectivity between the anterior insula and ACC. These findings highlight a key role of the insula in manifestation of the core symptoms of IGD and the importance to examine functional abnormalities of the anterior and posterior insula separately in IGDs.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Zhang JT,Yao YW,Li CS,Zang YF,Shen ZJ,Liu L,Wang LJ,Liu B,Fang XYdoi
10.1111/adb.12247subject
Has Abstractpub_date
2016-05-01 00:00:00pages
743-51issue
3eissn
1355-6215issn
1369-1600journal_volume
21pub_type
杂志文章abstract::Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...
journal_title:Addiction biology
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journal_title:Addiction biology
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journal_title:Addiction biology
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.13001
更新日期:2021-01-28 00:00:00
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journal_title:Addiction biology
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journal_title:Addiction biology
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journal_title:Addiction biology
pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12531
更新日期:2018-03-01 00:00:00
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更新日期:2008-09-01 00:00:00
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journal_title:Addiction biology
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00423.x
更新日期:2012-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12188
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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