Abstract:
:Nicotine withdrawal is associated with subtle working memory deficits that predict subsequent relapse. We examined the neural substrates underlying these processes in treatment-seeking smokers, and explored the moderating influence of age on abstinence-induced alterations in brain activity and performance. Sixty-three smokers participated in two blood oxygen level-dependent (BOLD) functional magnetic resonance imaging scans while performing a visual N-back task on two separate occasions: smoking as usual and after 24 hours of biochemically confirmed abstinence (order counterbalanced). Abstinence (versus smoking) led to reduced accuracy, slower median correct response time and reduced BOLD signal change in the three a priori regions of interest: medial frontal/cingulate gyrus and right and left dorsolateral prefrontal cortex. Significant age × session effects were found for BOLD signal change in all three regions, as well as for withdrawal and craving; for all measures, abstinence effects were attenuated in smokers aged ≥50 years compared with those <50 years old. These results suggest that abstinence effects on neurocognitive function may be more pronounced for younger smokers, and may indicate a new avenue for research exploring mechanisms underlying age differences in smoking cessation success.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Falcone M,Wileyto EP,Ruparel K,Gerraty RT,LaPrate L,Detre JA,Gur R,Loughead J,Lerman Cdoi
10.1111/adb.12051subject
Has Abstractpub_date
2014-09-01 00:00:00pages
907-17issue
5eissn
1355-6215issn
1369-1600journal_volume
19pub_type
杂志文章abstract::Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...
journal_title:Addiction biology
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journal_title:Addiction biology
pub_type: 杂志文章,评审
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journal_title:Addiction biology
pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章
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journal_title:Addiction biology
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12184
更新日期:2016-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00252.x
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journal_title:Addiction biology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12751
更新日期:2020-03-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00404.x
更新日期:2013-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12316
更新日期:2017-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章,评审
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