Abstract：
:It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subject's drinking history and variables of executive functioning. Attentional bias was assessed in 30 alcohol-dependent patients using a visual dot-probe task with a picture presentation time of 50 ms. In addition, patients completed a variety of different cognitive tasks such as attention, continuous performance, working memory, set shifting and inhibitory control tests. Based on correlation analysis we split the patient sample on the median with regard to the duration of alcohol dependence and our results indicated a significant attentional bias towards alcohol-associated pictures in patients dependent for less than 9 years, but not in patients with a longer duration of dependence. The two patient samples differed significantly with regard to attention and working memory functioning with patients who were dependent for more than 9 years showing a greater impairment. When impairment of attention and working memory were controlled for, the group differences in attentional bias were no longer significant. Our results indicate that differences with regard to drinking-related variables as well as cognitive functioning seem to modulate attentional bias and need to be taken into account in models of drinking maintenance.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Loeber S,Vollstädt-Klein S,von der Goltz C,Flor H,Mann K,Kiefer Fdoi
10.1111/j.1369-1600.2009.00146.xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
194-203issue
2eissn
1355-6215issn
1369-1600pii
ADB146journal_volume
14pub_type
杂志文章abstract：:The capacity of the liver to synthesize insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) may be compromised by alcohol. The characteristics of IGFBP-3 variants obtained from healthy individuals and patients with alcoholic cirrhosis (ALC) were compared. Concanavalin A (Con A) affinity electrophore...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/1355621031000069927
更新日期：2003-03-01 00:00:00
abstract：:The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consum...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12277
更新日期：2016-03-01 00:00:00
abstract：:Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2012.00507.x
更新日期：2014-03-01 00:00:00
abstract：:Through incentive learning, the emotional experience of a reward in a relevant need state (e.g. hunger for food) sets the incentive value that guides the performance of actions that earn that reward when the need state is encountered again. Opiate withdrawal has been proposed as a need state in which, through experien...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12172
更新日期：2016-03-01 00:00:00
abstract：:Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result of altered gene expression in various brain regions. The present study investigated brain region-specific changes in the pattern and magnitude of gene expression immediately following chronic intermittent ethanol (CIE) exposure...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00357.x
更新日期：2012-03-01 00:00:00
abstract：:Hypothalamic orexin/hypocretin (Orx/Hcrt) neurons are thought to mediate both food-reinforced behaviors and behavior motivated by drugs of abuse. However, the relative role of the Orx/Hcrt system in behavior motivated by food versus drugs of abuse remains unclear. This investigation addressed this question by contrast...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12441
更新日期：2018-01-01 00:00:00
abstract：:Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12632
更新日期：2019-07-01 00:00:00
abstract：:Combined anorectic-alcohol misuse is a prevalent problem in Brazil. In order to understand better the interactive effects of ethanol (EtOH) and mazindol (MZ), we examined the effects of EtOH (1.2 g/kg) and MZ (5.0 mg/kg) given alone or in combination, on mouse behaviour. The results indicate that EtOH plus MZ induces ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/1355621961000124926
更新日期：1996-01-01 00:00:00
abstract：:Hangover refers to the cluster of physiological and behavioral symptoms that occur following the end of a drinking episode. While hangover has been studied after the typical oral consumption of alcohol, the occurrence of hangover following intravenous (IV) alcohol administration in human laboratory studies has not bee...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12469
更新日期：2018-01-01 00:00:00
abstract：:The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim, male and female C57BL/6J mice (n = 60 per sex) were exposed to the drinking in the dark (DID) model for 4 weeks (DID-1 to DID-4). Dose-response effects of CBD on t...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12765
更新日期：2020-05-01 00:00:00
abstract：:Copy number variations (CNVs) can alter the DNA sequence in blocks ranging from kilobases to megabases, involving more total nucleotides than single nucleotide polymorphisms. Yet, its impact in humans is far from fully understood. In this study, we investigate the relationship of genome-wide CNVs with brain function e...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00393.x
更新日期：2013-05-01 00:00:00
abstract：:Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12338
更新日期：2017-05-01 00:00:00
abstract：:Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2011.00367.x
更新日期：2012-09-01 00:00:00
abstract：:Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or preven...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12161
更新日期：2015-07-01 00:00:00
abstract：:Several studies have emphasized the role of learning in the development of rapid and chronic tolerances. Recently, it was shown that the NMDA antagonists MK-801(dizocilpine) and ketamine block the development of tolerance to ethanol in rats submitted to tilt-plane apparatus. The present study examines the generality o...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219872344
更新日期：1998-01-01 00:00:00
abstract：:Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12531
更新日期：2018-03-01 00:00:00
abstract：:Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and the cystine-glutamate exchange protein xCT within the nucleus accumbens core (NAcore). N-acetylcysteine (NAC) has been shown to restore these proteins in a rodent model of drug addiction and relapse. How...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12797
更新日期：2020-09-01 00:00:00
abstract：:Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12883
更新日期：2021-01-01 00:00:00
abstract：:Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12740
更新日期：2020-03-01 00:00:00
abstract：:Transferrin (T f) and its carbohydrate-deficient isoform (CDT) were measured by radioimmunoassay in phosphate-buffered saline extracts of two informative areas of cerebral cortex tissue obtained at autopsy from alcoholics without other associated disease (n = 4); alcoholics with cirrhosis of the liver (n = 4) and agem...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219772633
更新日期：1997-07-01 00:00:00
abstract：:In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of 'Pathological Gambling' ('PG'). Some academic opinion favors leaving PG in the 'Impulse Control Disorder' ('ICD') category, as in ICD-10, whereas others a...
journal_title：Addiction biology
pub_type： 杂志文章,评审
doi：10.1111/adb.12378
更新日期：2017-07-01 00:00:00
abstract：:The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are more likely to use alcohol to cope w...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12784
更新日期：2019-09-01 00:00:00
abstract：:The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12058
更新日期：2014-09-01 00:00:00
abstract：:Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12480
更新日期：2018-01-01 00:00:00
abstract：:Abuse of alcohol is a major clinical problem with far-reaching health consequences. Understanding the environmental and genetic factors that contribute to alcohol-related behaviors is a potential gateway for developing novel therapeutic approaches for patients that abuse the drug. To this end, we have used Drosophila ...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12779
更新日期：2020-07-01 00:00:00
abstract：:The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2008.00145.x
更新日期：2009-07-01 00:00:00
abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...
journal_title：Addiction biology
pub_type： 评论,杂志文章
doi：10.1111/adb.12265
更新日期：2017-01-01 00:00:00
abstract：:Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12815
更新日期：2020-07-01 00:00:00
abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219971542
更新日期：1999-07-01 00:00:00
abstract：:Previous work suggests a role for dopamine D3-like receptors in psychostimulant reinforcement. The development of new compounds acting selectively at dopamine D3 receptors has opened new possibilities to explore the role of these receptors in animal models of psychostimulant dependence. Here we investigated whether th...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2010.00211.x
更新日期：2010-07-01 00:00:00
