Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme.

abstract：:Previous studies on acetaldehyde dehydrogenase 2 (ALDH2) focused on drinking behavior or alcoholism because the ALDH2*2 allele protects against the risk of developing alcoholism. The mechanism provides that the ALDH2 gene's protective effect is also involved in dopamine metabolism. The interaction of the ALDH2 gene wi...

journal_title：Addiction biology

authors： Lu RB,Lee JF,Huang SY,Lee SY,Chang YH,Kuo PH,Chen SL,Chen SH,Chu CH,Lin WW,Wu PL,Ko HC

更新日期：2012-09-01 00:00:00

abstract：:Withdrawal of opioid drugs leads to a cluster of unpleasant symptoms in dependent subjects. These symptoms are stimulatory in nature and oppose the acute, inhibitory effects of opiates. The conventional theory that explains the opioid withdrawal syndrome assumes that chronic usage of opioid drugs activates compensator...

journal_title：Addiction biology

authors： Rubovitch V,Pick CG,Sarne Y

更新日期：2009-09-01 00:00:00

abstract：:Several studies show that substance dependence disorders are characterized by an enhanced processing of substance-related stimuli. The present study was designed to examine the association between craving levels and selective processing of drug cues in cocaine-dependent patients using event-related brain potentials (E...

journal_title：Addiction biology

authors： Franken IH,Dietvorst RC,Hesselmans M,Franzek EJ,van de Wetering BJ,Van Strien JW

更新日期：2008-09-01 00:00:00

abstract：:Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide. These mushrooms represent a growing problem regarding hallucinogenic drug abuse. Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocy...

journal_title：Addiction biology

authors： Passie T,Seifert J,Schneider U,Emrich HM

更新日期：2002-10-01 00:00:00

abstract：:Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...

journal_title：Addiction biology

authors： Solecki WB,Szklarczyk K,Pradel K,Kwiatkowska K,Dobrzański G,Przewłocki R

更新日期：2018-03-01 00:00:00

abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...

journal_title：Addiction biology

authors： Tam PG

更新日期：2017-01-01 00:00:00

abstract：:Recent studies in animal models have shown that the nociceptin system, comprising nociceptin (or OFQ/N, encoded by PNOC) and the nociceptin receptor (an opioid receptor-like protein encoded by OPRL1), may be involved in alcohol and other drug reward pathways. To determine whether the nociceptin system is associated wi...

journal_title：Addiction biology

authors： Xuei X,Flury-Wetherill L,Almasy L,Bierut L,Tischfield J,Schuckit M,Nurnberger JI Jr,Foroud T,Edenberg HJ

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as a potential treatment for alcohol use disorder with much unexplained variation in response to treatment efficacy and dose regimen. Several positive studies include patients with alcoholic liver disease (ALD) and/or hi...

journal_title：Addiction biology

authors： Morley KC,Lagopoulos J,Logge W,Baillie A,Adams C,Haber PS

更新日期：2020-01-01 00:00:00

abstract：:In utero exposure of fetuses to tobacco is associated with reduced birth weight. We hypothesized that this may be due to the toxic effect of carbon monoxide (CO) from tobacco, which has previously been described to damage mitochondria in non-pregnant adult smokers. Maternal peripheral blood mononuclear cells (PBMCs), ...

journal_title：Addiction biology

authors： Garrabou G,Hernàndez AS,Catalán García M,Morén C,Tobías E,Córdoba S,López M,Figueras F,Grau JM,Cardellach F

更新日期：2016-01-01 00:00:00

abstract：:Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction ...

journal_title：Addiction biology

authors： Barrós-Loscertales A,Costumero V,Rosell-Negre P,Fuentes-Claramonte P,Llopis-Llacer JJ,Bustamante JC

更新日期：2020-07-01 00:00:00

abstract：:Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...

journal_title：Addiction biology

authors： Carbo-Gas M,Vazquez-Sanroman D,Aguirre-Manzo L,Coria-Avila GA,Manzo J,Sanchis-Segura C,Miquel M

更新日期：2014-01-01 00:00:00

abstract：:Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2...

journal_title：Addiction biology

authors： Wang X,Liu Y,Jia M,Sun X,Wang N,Li Y,Cui C

更新日期：2018-09-01 00:00:00

abstract：:Animal and cross-sectional human studies suggest that chronic cocaine use is associated with altered responsivity of the hypothalamic-pituitary-adrenal axis to stress. Moreover, increased susceptibility to stress has been proposed as an important factor for development, maintenance and relapse of cocaine addiction. As...

journal_title：Addiction biology

authors： Schote AB,Jäger K,Kroll SL,Vonmoos M,Hulka LM,Preller KH,Meyer J,Grünblatt E,Quednow BB

更新日期：2019-07-01 00:00:00

abstract：:Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...

journal_title：Addiction biology

authors： Mori T,Rahmadi M,Yoshizawa K,Itoh T,Shibasaki M,Suzuki T

更新日期：2014-05-01 00:00:00

abstract：:Although adolescents are a group heavily targeted by the e-cigarette industry, research in cue-reactivity has not previously examined adolescents' behavioral and neural responses to e-cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n...

journal_title：Addiction biology

authors： Chen Y,Fowler CH,Papa VB,Lepping RJ,Brucks MG,Fox AT,Martin LE

更新日期：2018-03-01 00:00:00

abstract：:Cannabinoid type 1 (CB1) receptors control the motivational properties and reinforcing effects of nicotine. Indeed, peripheral administration of a CB1 receptor antagonist dramatically decreases both nicotine taking and seeking. However, the neural substrates through which the cannabinoid CB1 receptors regulate the vol...

journal_title：Addiction biology

authors： Simonnet A,Cador M,Caille S

更新日期：2013-11-01 00:00:00

abstract：:Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males ...

journal_title：Addiction biology

authors： Dunn KE,Weerts EM,Huhn AS,Schroeder JR,Tompkins DA,Bigelow GE,Strain EC

更新日期：2020-01-01 00:00:00

abstract：:To gain a better insight into the alterations of brain function after chronic ethanol, we measured the release of various neurotransmitters from nerve terminals of cortex and hippocampus isolated fm rats chronically fed with ethanol. The K+-evoked release of [3H]acetylcholine (ACh), f[H]dopamine (DA), [3H] glutamate(G...

journal_title：Addiction biology

authors： Sabriá J,Torres D,Pastó M,Peralba JM,Allali-Hassani A,Parés X

更新日期：2003-09-01 00:00:00

abstract：:Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor increasing vulnerability involves reduced expression of the serotonin transporter (5-HTT). Human s...

journal_title：Addiction biology

authors： Karel P,Van der Toorn A,Vanderschuren L,Guo C,Sadighi Alvandi M,Reneman L,Dijkhuizen R,Verheij MMM,Homberg JR

更新日期：2020-01-01 00:00:00

abstract：:Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investig...

journal_title：Addiction biology

authors： Martin-Rodriguez JF,Ruiz-Veguilla M,Alvarez de Toledo P,Aizpurua-Olaizola O,Zarandona I,Canal-Rivero M,Rodriguez-Baena A,Mir P

更新日期：2020-04-23 00:00:00

abstract：:The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist such as an abused drug phencyclidine (PCP) causes the induction of heat shock protein HSP-70, a sensitive marker of neuronal injury, in the retrosplenial cortex of rat brain. The present study was undertaken to examine the role of a -amino-3- hydroxy-...

journal_title：Addiction biology

authors： Narita N,Hashimoto K,Tomitaka S,Minabe Y,Yamazaki K

更新日期：1997-01-01 00:00:00

abstract：:Ketamine, a non-competitive N-methyl-D-aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when ...

journal_title：Addiction biology

authors： Sun L,Li Q,Li Q,Zhang Y,Liu D,Jiang H,Pan F,Yew DT

更新日期：2014-03-01 00:00:00

abstract：:Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug...

journal_title：Addiction biology

authors： Roura-Martínez D,Ucha M,Orihuel J,Ballesteros-Yáñez I,Castillo CA,Marcos A,Ambrosio E,Higuera-Matas A

更新日期：2020-03-01 00:00:00

abstract：:Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing m...

journal_title：Addiction biology

authors： Lao-Peregrín C,Ballesteros JJ,Fernández M,Zamora-Moratalla A,Saavedra A,Gómez Lázaro M,Pérez-Navarro E,Burks D,Martín ED

更新日期：2017-11-01 00:00:00

abstract：:Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the study of voluntary binge-like drinking (BD) in outbred Long-Evans rats by combining intermittent access to 20% ethanol in a two-bottle choice (IA2BC) paradigm t...

journal_title：Addiction biology

authors： Sauton P,Deschamps C,Jeanblanc V,Pierrefiche O,Jeanblanc J,Naassila M

更新日期：2020-12-16 00:00:00

abstract：:Schizophrenia is a mental disorder characterized by a series of positive, negative or cognitive symptoms but with also the particularity of exhibiting a high rate of co-morbid use of drugs of abuse. While more than 80% of schizophrenics are smokers, the second most consumed drug is alcohol, with dramatic consequences ...

journal_title：Addiction biology

authors： Jeanblanc J,Balguerie K,Coune F,Legastelois R,Jeanblanc V,Naassila M

更新日期：2015-05-01 00:00:00

abstract：:Alcohol exposure during fetal and early postnatal development can lead to an increased incidence of later life adult-onset diseases. Examples include central nervous system dysfunction, depression, anxiety, hyperactivity, and an inability to deal with stressful situations, increased infection and cancer. Direct effect...

journal_title：Addiction biology

authors： Sarkar DK

更新日期：2016-01-01 00:00:00

abstract：:Betel quid chewing has been claimed to produce a sense of well-being, euphoria, warm sensation of the body, sweating, salivation, palpitation, heightened alertness and increased capacity to work. These effects suggest that betel quid chewing affects predominantly the central and autonomic nervous systems. Several stud...

journal_title：Addiction biology

authors： Chu NS

更新日期：2002-01-01 00:00:00

abstract：:Transferrin (T f) and its carbohydrate-deficient isoform (CDT) were measured by radioimmunoassay in phosphate-buffered saline extracts of two informative areas of cerebral cortex tissue obtained at autopsy from alcoholics without other associated disease (n = 4); alcoholics with cirrhosis of the liver (n = 4) and agem...

journal_title：Addiction biology

authors： Dodd PR,Eckert AL,Fletcher LM,Kril JJ,Harper CG,Halliday JW

更新日期：1997-07-01 00:00:00

abstract：:Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...

journal_title：Addiction biology

authors： de Miguel E,Vekovischeva O,Kuokkanen K,Vesajoki M,Paasikoski N,Kaskinoro J,Myllymäki M,Lainiola M,Janhunen SK,Hyytiä P,Linden AM,Korpi ER

更新日期：2019-11-01 00:00:00