Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence.

Abstract:

:While the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. The focus of the present study is to determine whether genetic variation in the tryptophan hydroxylase-2 (TPH2) gene, which encodes the enzyme responsible for synthesis of the majority of the serotonin contained in neurons of the central nervous system, contributes to the pathophysiology of cocaine dependence. To examine this hypothesis, we used a case-control study design in which the genotype and allele distributions for six single nucleotide polymorphisms (SNPs) in the TPH2 gene were compared between cocaine-dependent (n = 299) and control individuals (n = 208) of African descent. The results indicate that none of the SNPs in the TPH2 gene examined in this study associate with the cocaine-dependent phenotype. This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects.

journal_name

Addict Biol

journal_title

Addiction biology

authors

Dahl JP,Cubells JF,Ray R,Weller AE,Lohoff FW,Ferraro TN,Oslin DW,Kampman KM,Dackis C,Tang Y,Gelernter J,Kranzler HR,O'Brien CP,Berrettini WH

doi

10.1111/j.1369-1600.2006.00005.x

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

76-83

issue

1

eissn

1355-6215

issn

1369-1600

pii

ADB005

journal_volume

11

pub_type

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