Oxidation of acetaldehyde by isolated aortic rings of UChA and UChB rats.

abstract：:Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...

journal_title：Addiction biology

authors： Ledesma JC,Rodríguez-Arias M,Gavito AL,Sánchez-Pérez AM,Viña J,Medina Vera D,Rodríguez de Fonseca F,Miñarro J

更新日期：2021-01-01 00:00:00

abstract：:Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...

journal_title：Addiction biology

authors： Markou A,Li J,Tse K,Li X

更新日期：2018-01-01 00:00:00

abstract：:Copy number variations (CNVs) can alter the DNA sequence in blocks ranging from kilobases to megabases, involving more total nucleotides than single nucleotide polymorphisms. Yet, its impact in humans is far from fully understood. In this study, we investigate the relationship of genome-wide CNVs with brain function e...

journal_title：Addiction biology

authors： Liu J,Calhoun VD,Chen J,Claus ED,Hutchison KE

更新日期：2013-05-01 00:00:00

abstract：:The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...

journal_title：Addiction biology

authors： McLachlan-Troup N,Taylor GW,Trathen BC

更新日期：2001-07-01 00:00:00

abstract：:Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF1 and CRF2 receptor mRNA. Furthermore, the ascending NI relaxin-3 syst...

journal_title：Addiction biology

authors： Walker LC,Kastman HE,Koeleman JA,Smith CM,Perry CJ,Krstew EV,Gundlach AL,Lawrence AJ

更新日期：2017-11-01 00:00:00

abstract：:We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two...

journal_title：Addiction biology

authors： Selvas A,Coria SM,Kastanauskaite A,Fernaud-Espinosa I,DeFelipe J,Ambrosio E,Miguéns M

更新日期：2017-01-01 00:00:00

abstract：:Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...

journal_title：Addiction biology

authors： Teichtahl H,Wang D,Cunnington D,Kronborg I,Goodman C,Prodromidis A,Drummer O

更新日期：2004-09-01 00:00:00

abstract：:Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...

journal_title：Addiction biology

authors： Tabernero MJ,Bermejo AM,Fernandez P

更新日期：1999-10-01 00:00:00

abstract：:Hypothalamic orexin/hypocretin (Orx/Hcrt) neurons are thought to mediate both food-reinforced behaviors and behavior motivated by drugs of abuse. However, the relative role of the Orx/Hcrt system in behavior motivated by food versus drugs of abuse remains unclear. This investigation addressed this question by contrast...

journal_title：Addiction biology

authors： Martin-Fardon R,Cauvi G,Kerr TM,Weiss F

更新日期：2018-01-01 00:00:00

abstract：:Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...

journal_title：Addiction biology

authors： Rolland B,Dricot L,Creupelandt C,Maurage P,De Timary P

更新日期：2020-03-01 00:00:00

abstract：:Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subj...

journal_title：Addiction biology

authors： Jeong BS,Han DH,Kim SM,Lee SW,Renshaw PF

更新日期：2016-05-01 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:Previous work suggests a role for dopamine D3-like receptors in psychostimulant reinforcement. The development of new compounds acting selectively at dopamine D3 receptors has opened new possibilities to explore the role of these receptors in animal models of psychostimulant dependence. Here we investigated whether th...

journal_title：Addiction biology

authors： Orio L,Wee S,Newman AH,Pulvirenti L,Koob GF

更新日期：2010-07-01 00:00:00

abstract：:A major finding--that (-)-trans-Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB(1) and CB(2), and that...

journal_title：Addiction biology

authors： Pertwee RG

更新日期：2008-06-01 00:00:00

abstract：:Moderately sized, case-control studies have related alcohol dependence in middle-aged in-patients to lower second-to-fourth finger length ratio (2D:4D), a proxy for prenatal hyperandrogenization. As primary aim, we here intended to confirm that lower 2D:4D is also associated with Diagnostic and Statistical Manual of M...

journal_title：Addiction biology

authors： Lenz B,Mühle C,Cohort Study on Substance Use Risk Factors.,Kornhuber J

更新日期：2020-07-01 00:00:00

abstract：:Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...

journal_title：Addiction biology

authors： Vaquero L,Cámara E,Sampedro F,Pérez de Los Cobos J,Batlle F,Fabregas JM,Sales JA,Cervantes M,Ferrer X,Lazcano G,Rodríguez-Fornells A,Riba J

更新日期：2017-05-01 00:00:00

abstract：:This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...

journal_title：Addiction biology

authors： Tam PG

更新日期：2017-01-01 00:00:00

abstract：:Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...

journal_title：Addiction biology

authors： Pettorruso M,Martinotti G,Cocciolillo F,De Risio L,Cinquino A,Di Nicola M,Camardese G,Migliara G,Moccia L,Conte E,Janiri L,Di Giuda D

更新日期：2019-09-01 00:00:00

abstract：:The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...

journal_title：Addiction biology

authors： Wolff CB,Peters TJ,Keating J,Gardner WN

更新日期：1999-04-01 00:00:00

abstract：:Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug-predictive cues and is thought to be a critical substrate for drug craving, but the downstream neural circuit effectors of the IC that med...

journal_title：Addiction biology

authors： Girven KS,Aroni S,Navarrete J,Marino RAM,McKeon PN,Cheer JF,Sparta DR

更新日期：2020-08-20 00:00:00

abstract：:Withdrawal of opioid drugs leads to a cluster of unpleasant symptoms in dependent subjects. These symptoms are stimulatory in nature and oppose the acute, inhibitory effects of opiates. The conventional theory that explains the opioid withdrawal syndrome assumes that chronic usage of opioid drugs activates compensator...

journal_title：Addiction biology

authors： Rubovitch V,Pick CG,Sarne Y

更新日期：2009-09-01 00:00:00

abstract：:Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2...

journal_title：Addiction biology

authors： Wang X,Liu Y,Jia M,Sun X,Wang N,Li Y,Cui C

更新日期：2018-09-01 00:00:00

abstract：:Several genetic polymorphisms have been reported to be associated with alcohol withdrawal seizures (AWS) and delirium tremens (DT). To replicate and further explore these findings, we investigated the effects of 12 previously reported candidate genetic variations in two groups of alcohol-dependent European Americans w...

journal_title：Addiction biology

authors： Karpyak VM,Biernacka JM,Weg MW,Stevens SR,Cunningham JM,Mrazek DA,Black JL

更新日期：2010-01-01 00:00:00

abstract：:Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol dependence syndrome (ADS) in East Asian populations. Recently, attention has focused on the role of these SNPs in determining ADS risk in European populations. To ...

journal_title：Addiction biology

authors： Way M,McQuillin A,Saini J,Ruparelia K,Lydall GJ,Guerrini I,Ball D,Smith I,Quadri G,Thomson AD,Kasiakogia-Worlley K,Cherian R,Gunwardena P,Rao H,Kottalgi G,Patel S,Hillman A,Douglas E,Qureshi SY,Reynolds G,Jauhar S

更新日期：2015-05-01 00:00:00

abstract：:Adolescence is characterized by considerable brain maturation that coincides with the development of adult behavior. Binge drinking is common during adolescence and can have deleterious effects on brain maturation because of the heightened neuroplasticity of the adolescent brain. Using an animal model of adolescent in...

journal_title：Addiction biology

authors： Vetreno RP,Yaxley R,Paniagua B,Crews FT

更新日期：2016-07-01 00:00:00

abstract：:The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking. We investigated the role of adult hippocampal neur...

journal_title：Addiction biology

authors： Luján MÁ,Cantacorps L,Valverde O

更新日期：2020-07-01 00:00:00

abstract：:Associations between nicotine in cigarettes and food consumption may alter the incentive value of food such that food cue-reactivity is exaggerated during abstinence from smoking. This effect may contribute to the weight gain associated with cessation of smoking. We examined the effects of nicotine (0.4 mg/kg base sub...

journal_title：Addiction biology

authors： Grimm JW,Ratliff C,North K,Barnes J,Collins S

更新日期：2012-05-01 00:00:00

abstract：:The A118G single nucleotide polymorphism (SNP) of the human μ-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. A mouse model that possesses the equivalent subs...

journal_title：Addiction biology

authors： Wang YJ,Huang P,Blendy JA,Liu-Chen LY

更新日期：2014-05-01 00:00:00

abstract：:Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspe...

journal_title：Addiction biology

authors： McKee SA

更新日期：2009-01-01 00:00:00

abstract：:Although substantial research effort has focused on developing pharmacological treatments for cocaine abuse, no effective medications have been developed. Recent studies show that enzymes that metabolize cocaine in the periphery, forestalling its entry into the brain, can prevent cocaine toxicity and its behavioral ef...

journal_title：Addiction biology

authors： Schindler CW,Justinova Z,Lafleur D,Woods D,Roschke V,Hallak H,Sklair-Tavron L,Redhi GH,Yasar S,Bergman J,Goldberg SR

更新日期：2013-01-01 00:00:00