当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum.

Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum.

Abstract：

:Thyroid hormone is a major regulator of postnatal brain development, but the precise molecular mechanisms underlying its action in this organ remain poorly understood. We used microarray analysis to identify new target genes in brain. Thyroid hormone treatment of hypothyroid Pax8(-/-) knockout mice, which lack thyroid follicular cells, had a very limited global effect on brain transcripts. This analysis mainly identified cyclin D2 as a new thyroid hormone target gene in the cerebellum of hypothyroid mice. Thyroid hormone receptor (TRalpha and/or TRbeta) knockout mice studies provided further genetic evidence that cyclin D2 is likely to mediate the antiapoptotic effect exerted by thyroid hormone on the cerebellum external granular layer neuroblasts but that this transcriptional activation is not directly exerted by the thyroid hormone receptors.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Poguet AL,Legrand C,Feng X,Yen PM,Meltzer P,Samarut J,Flamant F

doi

10.1016/s0012-1606(02)00039-8

subject

Has Abstract

pub_date

2003-02-15 00:00:00

pages

188-99

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012160602000398

journal_volume

254

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • A protein of the sea urchin cortical granules is targeted to the fertilization envelope and contains an LDL-receptor-like motif.

    abstract：:Cortical granules of eggs contain a population of heterogeneous proteins that are sequestered selectively within the cortical granule during oogenesis and that participate in the block to polyspermy during the fertilization reaction. To begin to understand the targeting mechanism of proteins to this organelle, we have...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1033

    authors： Wessel GM

    更新日期：1995-01-01 00:00:00

  • The cortical granule serine protease CGSP1 of the sea urchin, Strongylocentrotus purpuratus, is autocatalytic and contains a low-density lipoprotein receptor-like domain.

    abstract：:Trypsin-like activity is secreted from eggs of many species at fertilization, and this activity is believed to be critical for the block to polyspermy. Here we show that a cortical granule serine protease of sea urchins is the major and perhaps only protease family member important for fertilization. Zymography assays...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9299

    authors： Haley SA,Wessel GM

    更新日期：1999-07-01 00:00:00

  • Retinoic acid regulation by CYP26 in vertebrate lens regeneration.

    abstract：:Xenopus laevis is among the few species that are capable of fully regenerating a lost lens de novo. This occurs upon removal of the lens, when secreted factors from the retina are permitted to reach the cornea epithelium and trigger it to form a new lens. Although many studies have investigated the retinal factors tha...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.12.036

    authors： Thomas AG,Henry JJ

    更新日期：2014-02-15 00:00:00

  • The involvement of Eph-Ephrin signaling in tissue separation and convergence during Xenopus gastrulation movements.

    abstract：:In Xenopus gastrulation, the involuting mesodermal and non-involuting ectodermal cells remain separated from each other, undergoing convergent extension. Here, we show that Eph-ephrin signaling is crucial for the tissue separation and convergence during gastrulation. The loss of EphA4 function results in aberrant gast...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.12.012

    authors： Park EC,Cho GS,Kim GH,Choi SC,Han JK

    更新日期：2011-02-15 00:00:00

  • Cell-specific expression in the silkmoth follicle: developmental characterization of a major chorion protein, its mRNA and gene.

    abstract：:Choriogenesis (eggshell formation) within the silkmoth Antheraea polyphemus proceeds in parallel for the two major subpopulations of follicle cells, diverging only during the very late period when aeropyle crown surface structures form in one region but not in the other. Correlated with their appearance is the synthes...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1301

    authors： Regier JC,Cole C,Leclerc RF

    更新日期：1993-11-01 00:00:00

  • Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes.

    abstract：:The GRAM domain was found in glucosyltransferases, myotubularins and other membrane-associated proteins. So far, functions for majority of these proteins are yet to be uncovered. In order to address the evolutionary and functional significance of this family members, we have performed a comprehensive investigation on ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.11.031

    authors： Jiang SY,Ramamoorthy R,Ramachandran S

    更新日期：2008-02-15 00:00:00

  • Hormonal control of gene amplification and transcription in the salivary gland chromosomes of Trichosia pubescens.

    abstract：:Trichosia pubescens larvae were ligated at different prepupal developmental stages in order to investigate whether ecdysterone acts just as a trigger or whether its presence in the hemolymph is constantly necessary for the induction of the late puffs, in particular the DNA puffs. The larvae were ligated in the middle ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90170-2

    authors： Amabis DC,Amabis JM

    更新日期：1984-03-01 00:00:00

  • Changes in endoplasmic reticulum structure during mouse oocyte maturation are controlled by the cytoskeleton and cytoplasmic dynein.

    abstract：:Oocyte maturation in mouse is associated with a dramatic reorganisation of the endoplasmic reticulum (ER) from a network of cytoplasmic accumulations in the germinal vesicle-stage oocyte (GV) to a network of distinctive cortical clusters in the metaphase II egg (MII). Multiple lines of evidence suggest that this redis...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.02.006

    authors： FitzHarris G,Marangos P,Carroll J

    更新日期：2007-05-01 00:00:00

  • Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro.

    abstract：:We have been studying oligodendrocyte generation in vitro to obtain insights into how the timely generation of these cells might be regulated. Our studies suggest the existence of timing mechanisms quite different from those of existing models, wherein it is proposed that timely oligodendrocyte generation is associate...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0280

    authors： Ibarrola N,Mayer-Pröschel M,Rodriguez-Peña A,Noble M

    更新日期：1996-11-25 00:00:00

  • Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.

    abstract：:The inner ear, the sensory organ responsible for hearing and balance, contains specialized sensory and non-sensory epithelia arranged in a highly complex three-dimensional structure. To achieve this complexity, a tight coordination between morphogenesis and cell fate specification is essential during otic development....

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.07.025

    authors： Vázquez-Echeverría C,Dominguez-Frutos E,Charnay P,Schimmang T,Pujades C

    更新日期：2008-10-01 00:00:00

  • Specification of neural precursor identity in the geophilomorph centipede Strigamia maritima.

    abstract：:Despite differences in the formation of neural precursors, all arthropod species analyzed so far generate about 30 single precursors (insects/crustaceans) or precursor groups (chelicerates/myriapods) per hemi-segment. In Drosophila, each precursor has a distinct identity conferred by segment polarity and dorso-ventral...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.11.029

    authors： Chipman AD,Stollewerk A

    更新日期：2006-02-15 00:00:00

  • Precambrian animal life: probable developmental and adult cnidarian forms from Southwest China.

    abstract：:The evolutionary divergence of cnidarian and bilaterian lineages from their remote metazoan ancestor occurred at an unknown depth in time before the Cambrian, since crown group representatives of each are found in Lower Cambrian fossil assemblages. We report here a variety of putative embryonic, larval, and adult micr...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0714

    authors： Chen JY,Oliveri P,Gao F,Dornbos SQ,Li CW,Bottjer DJ,Davidson EH

    更新日期：2002-08-01 00:00:00

  • Axis determination in polyspermic Xenopus laevis eggs.

    abstract：:Polyspermic Xenopus laevis eggs can be identified easily because of regions of pigment accumulation and white stripes, which arise by a nocodazole-sensitive process. Eggs containing up to four sperm are capable of forming a single embryonic axis. Dispermic eggs display two regions of pigment accumulation, one around e...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90262-9

    authors： Render JA,Elinson RP

    更新日期：1986-06-01 00:00:00

  • The extracellular matrix dimension of skeletal muscle development.

    abstract：:Cells anchor to substrates by binding to extracellular matrix (ECM). In addition to this anchoring function however, cell-ECM binding is a mechanism for cells to sense their surroundings and to communicate and coordinate behaviour amongst themselves. Several ECM molecules and their receptors play essential roles in mu...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2011.03.015

    authors： Thorsteinsdóttir S,Deries M,Cachaço AS,Bajanca F

    更新日期：2011-06-15 00:00:00

  • Defining a large set of full-length clones from a Xenopus tropicalis EST project.

    abstract：:Amphibian embryos from the genus Xenopus are among the best species for understanding early vertebrate development and for studying basic cell biological processes. Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics. Understanding the behavior of genes in this accessible m...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.04.023

    authors： Gilchrist MJ,Zorn AM,Voigt J,Smith JC,Papalopulu N,Amaya E

    更新日期：2004-07-15 00:00:00

  • Emergence of the mature myosin phenotype in the rat diaphragm muscle.

    abstract：:Immunohistochemical analysis of myosin heavy chain (MHC) isoform expression in perinatal and adult rat diaphragm muscles was performed with antibodies which permitted the identification of all known MHC isoforms found in typical rat muscles. Isoform switching, leading to the emergence of the adult phenotype, was more ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90473-g

    authors： LaFramboise WA,Daood MJ,Guthrie RD,Schiaffino S,Moretti P,Brozanski B,Ontell MP,Butler-Browne GS,Whalen RG,Ontell M

    更新日期：1991-03-01 00:00:00

  • Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.

    abstract：:Summary Sentence: Conditional ablation of AP-2 gamma results in a delay in skin development and abnormal expression of p63, K14, K1, filaggrin, repetin and secreted Ly6/Plaur domain containing 1, key genes required for epidermal development and differentiation. The development of the epidermis, a stratified squamous e...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.02.017

    authors： Guttormsen J,Koster MI,Stevens JR,Roop DR,Williams T,Winger QA

    更新日期：2008-05-01 00:00:00

  • An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cells.

    abstract：:The desmin gene encodes an intermediate filament protein that is present in skeletal, cardiac, and smooth muscle cells. This study shows that the 4-kb upstream region of the murine desmin promoter directs expression of a lacZ reporter gene throughout the heart from E7.5 and in skeletal muscle and vascular smooth muscl...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9865

    authors： Mericskay M,Parlakian A,Porteu A,Dandré F,Bonnet J,Paulin D,Li Z

    更新日期：2000-10-15 00:00:00

  • Age-associated increase in aneuploidy and changes in gene expression in mouse eggs.

    abstract：:An increase in the incidence of aneuploidy is well documented with increasing maternal age, in particular in human females. Remarkably, little is known regarding the underlying molecular basis for the age-associated increase in aneuploidy, which is a major source of decreased fertility in humans. Using mouse as a mode...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.01.048

    authors： Pan H,Ma P,Zhu W,Schultz RM

    更新日期：2008-04-15 00:00:00

  • Comparative biology of calcium signaling during fertilization and egg activation in animals.

    abstract：:During animal fertilizations, each oocyte or egg must produce a proper intracellular calcium signal for development to proceed normally. As a supplement to recent synopses of fertilization-induced calcium responses in mammals, this paper reviews the spatiotemporal properties of calcium signaling during fertilization a...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1006/dbio.1999.9340

    authors： Stricker SA

    更新日期：1999-07-15 00:00:00

  • Identification of a novel polypeptide involved in the formation of DNA-containing vesicles during macronuclear development in Tetrahymena.

    abstract：:An abundant phosphoprotein with an apparent molecular mass of 65 kDa (p65) has been identified that is enriched in developing new macronuclei (or anlagen) isolated from the holotrichous ciliate, Tetrahymena thermophila. During early stages of macronuclear development, p65 is actively synthesized and deposited into you...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1264

    authors： Madireddi MT,Davis MC,Allis CD

    更新日期：1994-10-01 00:00:00

  • Effect of prostaglandin E2 on cyclic AMP levels in limb cells of mouse mutant brachypodism.

    abstract：:Mouse embryo limb cells carrying either the brachypodism (bpH/bpH) mutation or its wild-type (+/+) allele were tested for their ability to accumulate cyclic AMP in response to prostaglandin E2 (PGE2) between Embryonic Days E12 and E14. Mutant cells exhibited a precocious increase in cyclic AMP. In the absence of PGE2 ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90372-p

    authors： Ballard TA,Elmer WA

    更新日期：1990-12-01 00:00:00

  • Studies on the differentiation of egg envelopes. I. The starfish, Astropecten aurantiacus.

    abstract：:We have studied the differentiation of the oocyte vitelline coat (VC) and jelly coat (JC) of the starfish, Astropecten aurantiacus. The precursor material of both envelopes is secreted by the oocyte while the follicle cells do not appear to participate in the secretory process. The first indication of differentiation ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(83)90296-8

    authors： Santella L,Monroy A,Rosati F

    更新日期：1983-10-01 00:00:00

  • Translocation of cAMP-dependent protein kinase to the nucleus during development of Dictyostelium discoideum.

    abstract：:The distribution of the catalytic and regulatory subunits of the cAMP-dependent protein kinase between cytoplasm and nucleus was determined during the development of Dictyostelium discoideum. In vegetative amoebae approximately 2% of the subunits were in the nucleus. During development there was an approximately 5-fol...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90221-6

    authors： Woffendin C,Chambers TC,Schaller KL,Leichtling BH,Rickenberg HV

    更新日期：1986-05-01 00:00:00

  • Glial progenitors of the neonatal subventricular zone differentiate asynchronously, leading to spatial dispersion of glial clones and to the persistence of immature glia in the adult mammalian CNS.

    abstract：:The subventricular zone (SVZ) of the developing mammalian forebrain gives rise to astrocytes and oligodendrocytes in the neocortex and white matter, and neurons in the olfactory bulb in perinatal life. We have examined the developmental fates and spatial distributions of the descendants of single SVZ cells by infectin...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.02.024

    authors： Zerlin M,Milosevic A,Goldman JE

    更新日期：2004-06-01 00:00:00

  • Gene regulation by the lysine demethylase KDM4A in Drosophila.

    abstract：:Lysine methylation of histones is associated with both transcriptionally active chromatin and with silent chromatin, depending on what residue is modified. Histone methyltransferases and demethylases ensure that histone methylations are dynamic and can vary depending on cell cycle- or developmental stage. KDM4A demeth...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.11.011

    authors： Crona F,Dahlberg O,Lundberg LE,Larsson J,Mannervik M

    更新日期：2013-01-15 00:00:00

  • Position-specific growth of mouse limb bud cells in vitro.

    abstract：:The relationship between cellular position and growth control has been studied in cultures of dissociated fragments of mouse limb bud cells. Using cells derived from various positions along the anterior-posterior axis of the limb bud we have developed culture conditions that optimize growth of positionally isolated ce...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90208-x

    authors： Shi C,Muneoka K

    更新日期：1992-05-01 00:00:00

  • Maturation of Xenopus oocytes is not accompanied by electrode-detectable calcium changes.

    abstract：:Ca2+-sensitive microelectrodes were used to study changes in cytoplasmic free calcium during progesterone-induced meiotic maturation in Xenopus laevis oocytes. In contrast to previous reports, no changes were detected during the maturation process, although a large activation pulse of Ca2+ was seen when in vitro matur...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90475-0

    authors： Robinson KR

    更新日期：1985-06-01 00:00:00

  • Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis.

    abstract：:Morphogenesis is a fascinating but complex and incompletely understood developmental process. The sensory lateral line system consists of only a few hundred cells and is experimentally accessible making it an excellent model system to interrogate the cellular and molecular mechanisms underlying segmental morphogenesis...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.10.022

    authors： Aman A,Nguyen M,Piotrowski T

    更新日期：2011-01-15 00:00:00

  • Nerve disperses preexisting acetylcholine receptor clusters prior to induction of receptor accumulation in Xenopus muscle cultures.

    abstract：:We have investigated the sequential changes of acetylcholine receptor (AChR) distribution on identified Xenopus laevis muscle cells in culture before and after innervation. AChRs on muscle cells were stained with tetramethylrhodamine-conjugated alpha-bungarotoxin and the distribution of AChR clusters was examined on a...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90006-x

    authors： Kuromi H,Kidokoro Y

    更新日期：1984-05-01 00:00:00