Abstract：
:AIDS patients frequently exhibit neurological disorders due to the neurotoxic events that result from HIV-1 and/or opportunistic infections in the brain. This review examines recent clinical findings related to HIV-1-associated dementia, and outlines current areas of basic research that may clarify how HIV-1-associated encephalopathy produces clinical symptoms of brain dysfunction.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Lawrence DM,Major EOdoi
10.1016/s1286-4579(02)01542-3subject
Has Abstractpub_date
2002-03-01 00:00:00pages
301-8issue
3eissn
1286-4579issn
1769-714Xpii
S1286457902015423journal_volume
4pub_type
杂志文章,评审abstract：:Tonsilloliths are a potential cause of oral malodor. In this study, microbial profiles and composition of tonsilloliths were determined using culture-independent molecular methods and scanning electron microscopy. 16S ribosomal RNA bacterial genes (16S rDNAs) isolated from tonsilloliths of 6 individuals were amplified...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.04.023
更新日期：2006-08-01 00:00:00
abstract：:Black rats (Rattus rattus) receiving Leishmania tropica injected intradermally into the ear were studied for the persistence of parasites and infectivity to natural sand fly vector. The mammalian host, the parasite, and the vector all originated from the endemic focus of Urfa, Turkey. Rats did not develop lesions or a...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(03)00046-7
更新日期：2003-04-01 00:00:00
abstract：:Surfactant protein C (SP-C) is a highly hydrophobic protein found in pulmonary surfactant. SP-C is synthesized exclusively in alveolar type II cells as a 21 kDa integral membrane precursor protein and subsequently proteolytically processed to a 3.7 kDa secretory protein. SP-C enhances the adsorption and spreading of p...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2006.04.009
更新日期：2006-07-01 00:00:00
abstract：:Two candidate DNA vaccines based on the proteins CFP10 and CFP21 encoded by regions of difference (RDs) of Mycobacterium tuberculosis were evaluated individually and in multivalent combination with the immunodominant protein Ag85B for induction of protective immune responses against experimental tuberculosis. Experime...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.04.025
更新日期：2006-08-01 00:00:00
abstract：:Intensive care unit (ICU)-acquired lower respiratory tract infections include acute tracheobronchitis and hospital-acquired and ventilator-associated pneumonia (VAP). Nosocomial pneumonia is the second most common hospital-acquired infection and the leading cause of death in hospital-acquired infections. The mortality...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.12.001
更新日期：2005-02-01 00:00:00
abstract：:In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are sensitive or even permissive to BoHV-4. These observations led to the hypothesis that cross-species transmission of BoH...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.08.007
更新日期：2007-11-01 00:00:00
abstract：:Twenty years ago we reported the first synthetic peptide-based anti-malarial vaccine named SPf66, which conferred limited protective efficacy in large-scale human field-trials. Our efforts towards a second vaccine generation based on the rational selection of conserved high activity binding peptides (HABPs) whose crit...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2007.02.004
更新日期：2007-05-01 00:00:00
abstract：:Onchocerca volvulus is a tissue-invasive parasitic nematode causing skin and eye pathology in human onchocerciasis. The filariae habour abundant intracellular Wolbachia bacteria, now recognised as obligatory symbionts, and therefore emerging as a novel target for chemotherapy. Recent research demonstrates that both th...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2003.11.003
更新日期：2004-01-01 00:00:00
abstract：:Following infection with Toxoplasma gondii, certain strains of mice, such as BALB/c, are genetically resistant to development of toxoplasmic encephalitis (TE) and establish a latent chronic infection as do humans. Thus, these animals appear to be a suitable model to analyze the mechanism of resistance to TE. Since the...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)00318-x
更新日期：2000-04-01 00:00:00
abstract：:Campylobacter jejuni is the predominant cause of antecedent infection in Guillain-Barré syndrome (GBS) or Miller Fisher syndrome (MFS). C. jejuni probably triggers GBS or MFS through molecular mimicry between bacterial sialylated lipo-oligosaccharides (LOS) and gangliosides in peripheral nerve tissue. We investigated ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.06.022
更新日期：2006-01-01 00:00:00
abstract：:This review summarizes and discusses virulence mechanisms whereby Porphyromonas gingivalis can persist in the oral cavity. It is proposed that the virulence of P. gingivalis is dependent, at least in part, upon its ability to establish a complex host-pathogen molecular crosstalk which subverts innate immunity. The sop...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.03.009
更新日期：2009-05-01 00:00:00
abstract：:We investigated the roles of the regulatory molecules glucocorticoid-induced TNF receptor family-related protein (GITR) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in murine infection with the nematode parasite Trichinella spiralis. Expression of GITR and CTLA-4 was rapidly upregulated on cells in the mes...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.08.013
更新日期：2006-10-01 00:00:00
abstract：:Infection of mice with Plasmodium berghei NK65 represents a well-recognized malaria model in which infection is accompanied by an intense hepatic inflammatory response. Enzyme-inducible nitric oxide synthase is an important regulator of inflammation and leukocyte recruitment in microvessels, but these functions have y...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.08.001
更新日期：2013-11-01 00:00:00
abstract：:While the Vif protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication in non-permissive cells, it is rapidly degraded intracellularly. We have previously suggested that the rapid turn-over of Vif is biologically meaningful to prevent detrimental effects of this protein at high express...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.04.011
更新日期：2004-07-01 00:00:00
abstract：:Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticat...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.10.002
更新日期：2010-02-01 00:00:00
abstract：:Eleven new cases of visceral leishmaniasis (VL) are reported in organ transplant patients in France. The epidemiological, clinical, biological, diagnostic and therapeutic features are reviewed, based on these cases and 46 cases reported in the literature. VL was most commonly associated with renal transplantation (77%...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2005.06.002
更新日期：2005-10-01 00:00:00
abstract：:The invasin protein encoded by enteropathogenic Yersinia allows entry of bacteria into intestinal M cells by binding to integrin receptors. In cultured cells, invasin-mediated uptake requires proteins involved in endocytosis and signaling to the cell cytoskeleton. At least four different factors have been demonstrated...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)90364-2
更新日期：2000-06-01 00:00:00
abstract：:Within the brain, glial cells are target cells for human cytomegalovirus (HCMV) and HIV. We infected cultures of unstimulated human microglial cells and astrocytes of embryonic origin and of monocyte-derived macrophages (MDM) with HCMV strain AD169 and observed down-regulation of the plasma membrane expression of CCR5...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(02)00022-9
更新日期：2002-11-01 00:00:00
abstract：:The Gram-negative bacterium Burkholderia cepacia has recently emerged as an important opportunistic pathogen in humans. This review focuses on the cellular aspects of B. cepacia infection and the dynamics of the B. cepacia-host cell interaction, including recent advances in our understanding of the ability of B. cepac...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01389-2
更新日期：2001-04-01 00:00:00
abstract：:Toxoplasma gondii can activate the nucleotide-binding domain and leucine-rich repeat-containing proteins NLRP1/3 inflammasomes, which mediate host resistance to the infection. Here we showed that deletion of mitogen-activated protein kinases MAPK1 and MAPK2 of type I parasite decreases acute virulence in mice, charact...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.07.004
更新日期：2016-11-01 00:00:00
abstract：:The differential recognition of fungal cell wall polysaccharides that program innate and adaptive immunity to the human opportunistic fungal pathogen Aspergillus fumigatus has been a focus of considerable interest. In a mouse model of fungal conidia aspiration, decreased relative levels of cell wall core carbohydrates...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2017.05.001
更新日期：2017-01-01 00:00:00
abstract：:In order to invade mammalian cells, Trypanosoma cruzi infective forms cause distinct rearrangements of membrane and host cell cytoskeletal components. Rho GTPases have been shown to regulate three separate signal transduction pathways, linking plasma membrane receptors to the assembly of distinct actin filament struct...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.01.009
更新日期：2004-04-01 00:00:00
abstract：:Histoplasma capsulatum is an important fungal pathogen in immunocompromised hosts, including AIDS patients. Experimental evidence suggests interferon-gamma (IFN) plays a role in host defense against H. capsulatum. In these studies we sought to demonstrate the importance of IFN in innate resistance to systemic histopla...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)01253-3
更新日期：2000-07-01 00:00:00
abstract：:Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflamma...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01645-3
更新日期：2002-09-01 00:00:00
abstract：:Respiratory syncytial virus (RSV) infection causes severe lower respiratory diseases in infancy, early childhood and the elderly. RSV infections respond poorly to current therapies. Therefore, we initiated a search for novel drug targets by investigating the characteristics and identity of RSV adhesion receptors on ma...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(02)00079-5
更新日期：2003-02-01 00:00:00
abstract：:Immature dendritic cells (Dcs) are characterised by high antigen uptake ability and poor T-cell stimulatory function. In contrast, mature DCs have a high stimulatory function and poor antigen uptake ability. Inflammatory stimuli induce DC maturation and migration from nonlymphoid tissues to lymphoid organs. We investi...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(99)00209-9
更新日期：1999-11-01 00:00:00
abstract：:Pseudomonas aeruginosa, a significant cause of human morbidity and mortality, uses a type 3 secretion system (T3SS) to inject effector toxins into host cells. We previously reported that P. aeruginosa uses ADP-ribosyltransferase (ADPr) activity of the T3SS effector ExoS for intracellular replication. T3SS translocon (...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2012.08.007
更新日期：2012-12-01 00:00:00
abstract：:Chlamydia pneumoniae is a respiratory pathogen involved in the onset of chronic inflammatory pathologies. Dendritic cells (DC), are major players in spreading of C. pneumoniae from the lungs, a crucial step leading to disseminated infections. Less is known concerning modulation of DC functions consequent to encounter ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2012.11.004
更新日期：2013-02-01 00:00:00
abstract：:Receptor-mediated endocytosis is known to play an important role in the entry of many viruses into host cells. However, the exact internalization mechanism has, until recently, remained poorly understood for many medically important viruses, including influenza. Developments in real-time imaging of single viruses as w...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2004.05.002
更新日期：2004-08-01 00:00:00
abstract：:Secreted phospholipase B (PLB1), which contains three enzyme activities in the one protein, is necessary for the initiation of pulmonary infection by Cryptococcus neoformans and for dissemination from the lung via the lymphatics and blood. Adhesion to lung epithelium is the first step in this process, therefore we inv...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.10.018
更新日期：2006-04-01 00:00:00
