Abstract：
:Respiratory syncytial virus (RSV) infection causes severe lower respiratory diseases in infancy, early childhood and the elderly. RSV infections respond poorly to current therapies. Therefore, we initiated a search for novel drug targets by investigating the characteristics and identity of RSV adhesion receptors on mammalian cells. Soluble human lectins, complex polysaccharides and a low molecular selectin antagonist, TBC1269, were used to characterise and isolate the RSV receptor on a human epithelial cell line (Hep2 cells). The binding characteristics of the RSV receptor on Hep2 cells were similar to those reported for L-selectin. The carbohydrate-based selectin antagonists, fucoidan and TBC 1269, inhibit RSV infection both in vitro and in a mouse model of infection. Furthermore, we have isolated annexin II as a potential RSV receptor on Hep2 cells. The expression of annexin II was increased after RSV infection. Recombinant annexin II binds to RSV G-protein, heparin and plasminogen and the binding is inhibited by a selectin antagonist, TBC1269. These findings indicate that inhibitors of annexin II could have potential in treating RSV infection.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Malhotra R,Ward M,Bright H,Priest R,Foster MR,Hurle M,Blair E,Bird Mdoi
10.1016/s1286-4579(02)00079-5subject
Has Abstractpub_date
2003-02-01 00:00:00pages
123-33issue
2eissn
1286-4579issn
1769-714Xpii
S1286457902000795journal_volume
5pub_type
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