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Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule.

Abstract：

:Attenuated Salmonella induce immunosuppressive, microbicidal and tumoricidal macrophages in mice. All three effects are mediated by activated macrophages producing nitric oxide (NO). NO is induced by the innate immune response pathway involving IL-12, NK cells and IFN-gamma in response to infection. NO has beneficial and detrimental effects on the host.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Eisenstein TK

doi

10.1016/s1286-4579(01)01482-4

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

1223-31

issue

14-15

eissn

1286-4579

issn

1769-714X

pii

S1286457901014824

journal_volume

3

pub_type

杂志文章,评审

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